{"_buckets": {"deposit": "a6db9e2d-a9b3-41c3-8641-8cc4eb13e775"}, "_deposit": {"id": "1371", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "1371"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00001371"}, "item_9_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2002-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1/2", "bibliographicPageEnd": "51", "bibliographicPageStart": "48", "bibliographicVolumeNumber": "46", "bibliographic_titles": [{"bibliographic_title": "Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University"}]}]}, "item_9_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "It was reported that accelerated allograft atherosclerosis is associated with usage of cyclosporin A (CsA). Although the immunosuppressive actions of CsA are extensively studied, the mechanisms of this adverse effect remains to be elucidated. We thus studied whether CsA affects the expression of interleukin (IL)-8 in the primary culture of human aortic smooth muscle cells (HASMC) since IL-8 recently has been shown to be a mitogen and a chemoattractant for vascular smooth muscle cells (VSMC). We also studied the effect of epidermal growth factor (EGF) on IL-8 expression because of its potent action of VSMC proliferation in the atherosclerotic lesion. Treatment of HASMC with CsA alone resulted in a significant increase in the IL-8 mRNA level. EGF also increased the mRNA level. CsA together with EGF further increased the IL-8 mRNA level. These results suggested that the CsA-dependent increase in IL- 8 in VSMC could be one of the mechanisms for its induced accelerated allograft atherosclerosis.", "subitem_description_type": "Abstract"}]}, "item_9_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "\u56fd\u7acb\u60c5\u5831\u5b66\u7814\u7a76\u6240\u3067\u96fb\u5b50\u5316\u3057\u305f\u30b3\u30f3\u30c6\u30f3\u30c4\u3092\u4f7f\u7528\u3057\u3066\u3044\u308b\u3002", "subitem_description_type": "Other"}]}, "item_9_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/2781"}]}, "item_9_identifier_registration": {"attribute_name": "ID\u767b\u9332", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/envm.46.48", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": 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"application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 448300.0, "url": {"label": "KJ00000034861.pdf", "url": "https://nagoya.repo.nii.ac.jp/record/1371/files/KJ00000034861.pdf"}, "version_id": "4bfbde81-3cf5-4b4a-b439-7fb89211634a"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "interleukin (IL)-8", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cyclosporin A (CsA)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "epidermal growth factor (EGF)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "accelerated allograft atherosclerosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "human aortic smooth muscle cells (HASMC)", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": 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InterIeukin-8 Gene Expression in Human Aortic Smooth Muscle Cells"], "weko_shared_id": null}