{"_buckets": {"deposit": "a6db9e2d-a9b3-41c3-8641-8cc4eb13e775"}, "_deposit": {"id": "1371", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "1371"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00001371", "sets": []}, "author_link": ["3117", "3118", "3119", "3120", "3121", "3122", "3123"], "item_1615768549627": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_9_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2002-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1/2", "bibliographicPageEnd": "51", "bibliographicPageStart": "48", "bibliographicVolumeNumber": "46", "bibliographic_titles": [{"bibliographic_title": "Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University", "bibliographic_titleLang": "en"}]}]}, "item_9_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "It was reported that accelerated allograft atherosclerosis is associated with usage of cyclosporin A (CsA). Although the immunosuppressive actions of CsA are extensively studied, the mechanisms of this adverse effect remains to be elucidated. We thus studied whether CsA affects the expression of interleukin (IL)-8 in the primary culture of human aortic smooth muscle cells (HASMC) since IL-8 recently has been shown to be a mitogen and a chemoattractant for vascular smooth muscle cells (VSMC). We also studied the effect of epidermal growth factor (EGF) on IL-8 expression because of its potent action of VSMC proliferation in the atherosclerotic lesion. Treatment of HASMC with CsA alone resulted in a significant increase in the IL-8 mRNA level. EGF also increased the mRNA level. CsA together with EGF further increased the IL-8 mRNA level. These results suggested that the CsA-dependent increase in IL- 8 in VSMC could be one of the mechanisms for its induced accelerated allograft atherosclerosis.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_9_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "国立情報学研究所で電子化したコンテンツを使用している。", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_9_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/2781"}]}, "item_9_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/envm.46.48", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Research Institute of Environmental Medicine, Nagoya University", "subitem_publisher_language": 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"nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "MITSUYAMA, Hirohito", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3119", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "OKUMURA, Kenji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3120", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "NIWATA, Satoru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3121", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "YAMAMOTO, Ryohei", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3122", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "SEO, Hisao", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3123", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00000034861.pdf", "filesize": [{"value": "448.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 448300.0, "url": {"label": "KJ00000034861.pdf", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/1371/files/KJ00000034861.pdf"}, "version_id": "4bfbde81-3cf5-4b4a-b439-7fb89211634a"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "interleukin (IL)-8", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cyclosporin A (CsA)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "epidermal growth factor (EGF)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "accelerated allograft atherosclerosis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "human aortic smooth muscle cells (HASMC)", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Effect of Epidermal Growth Factor and Cyclosporin A on InterIeukin-8 Gene Expression in Human Aortic Smooth Muscle Cells", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Effect of Epidermal Growth Factor and Cyclosporin A on InterIeukin-8 Gene Expression in Human Aortic Smooth Muscle Cells", "subitem_title_language": "en"}]}, "item_type_id": "9", "owner": "1", "path": ["335"], "permalink_uri": "https://doi.org/10.18999/envm.46.48", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2006-01-05"}, "publish_date": "2006-01-05", "publish_status": "0", "recid": "1371", "relation": {}, "relation_version_is_last": true, "title": ["Effect of Epidermal Growth Factor and Cyclosporin A on InterIeukin-8 Gene Expression in Human Aortic Smooth Muscle Cells"], "weko_shared_id": -1}