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  1. F100 環境医学研究所
  2. F100b 紀要
  3. Environmental medicine : annual report of the Research Institute of Environmental Medicine
  4. 46(1-2)

Effect of Epidermal Growth Factor and Cyclosporin A on InterIeukin-8 Gene Expression in Human Aortic Smooth Muscle Cells

https://doi.org/10.18999/envm.46.48
https://doi.org/10.18999/envm.46.48
bdb663dd-84f9-4605-9e38-6c92ba97e4fb
名前 / ファイル ライセンス アクション
KJ00000034861.pdf KJ00000034861.pdf (448.3 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2006-01-05
タイトル
タイトル Effect of Epidermal Growth Factor and Cyclosporin A on InterIeukin-8 Gene Expression in Human Aortic Smooth Muscle Cells
言語 en
著者 MURAKAMI, Ryuichiro

× MURAKAMI, Ryuichiro

WEKO 3117

en MURAKAMI, Ryuichiro

Search repository
KAMBE, Fukushi

× KAMBE, Fukushi

WEKO 3118

en KAMBE, Fukushi

Search repository
MITSUYAMA, Hirohito

× MITSUYAMA, Hirohito

WEKO 3119

en MITSUYAMA, Hirohito

Search repository
OKUMURA, Kenji

× OKUMURA, Kenji

WEKO 3120

en OKUMURA, Kenji

Search repository
NIWATA, Satoru

× NIWATA, Satoru

WEKO 3121

en NIWATA, Satoru

Search repository
YAMAMOTO, Ryohei

× YAMAMOTO, Ryohei

WEKO 3122

en YAMAMOTO, Ryohei

Search repository
SEO, Hisao

× SEO, Hisao

WEKO 3123

en SEO, Hisao

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 interleukin (IL)-8
キーワード
主題Scheme Other
主題 cyclosporin A (CsA)
キーワード
主題Scheme Other
主題 epidermal growth factor (EGF)
キーワード
主題Scheme Other
主題 accelerated allograft atherosclerosis
キーワード
主題Scheme Other
主題 human aortic smooth muscle cells (HASMC)
抄録
内容記述 It was reported that accelerated allograft atherosclerosis is associated with usage of cyclosporin A (CsA). Although the immunosuppressive actions of CsA are extensively studied, the mechanisms of this adverse effect remains to be elucidated. We thus studied whether CsA affects the expression of interleukin (IL)-8 in the primary culture of human aortic smooth muscle cells (HASMC) since IL-8 recently has been shown to be a mitogen and a chemoattractant for vascular smooth muscle cells (VSMC). We also studied the effect of epidermal growth factor (EGF) on IL-8 expression because of its potent action of VSMC proliferation in the atherosclerotic lesion. Treatment of HASMC with CsA alone resulted in a significant increase in the IL-8 mRNA level. EGF also increased the mRNA level. CsA together with EGF further increased the IL-8 mRNA level. These results suggested that the CsA-dependent increase in IL- 8 in VSMC could be one of the mechanisms for its induced accelerated allograft atherosclerosis.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 国立情報学研究所で電子化したコンテンツを使用している。
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Research Institute of Environmental Medicine, Nagoya University
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/envm.46.48
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 02870517
書誌情報 en : Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University

巻 46, 号 1/2, p. 48-51, 発行日 2002-12
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/2781
識別子タイプ HDL
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