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  1. F100 環境医学研究所
  2. F100b 紀要
  3. Environmental medicine : annual report of the Research Institute of Environmental Medicine
  4. 46(1-2)

Prevention of Demyelination Induced by Rapid correction of Hyponatremia in Mice

https://doi.org/10.18999/envm.46.58
https://doi.org/10.18999/envm.46.58
14581002-0be4-4204-8c2a-8d04b4d768e7
名前 / ファイル ライセンス アクション
KJ00000034864.pdf KJ00000034864.pdf (711.2 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2006-01-05
タイトル
タイトル Prevention of Demyelination Induced by Rapid correction of Hyponatremia in Mice
言語 en
著者 SUGIMURA, Yoshihisa

× SUGIMURA, Yoshihisa

WEKO 3135

en SUGIMURA, Yoshihisa

Search repository
TAKAGI, Hiroshi

× TAKAGI, Hiroshi

WEKO 3136

en TAKAGI, Hiroshi

Search repository
MURASE, Takashi

× MURASE, Takashi

WEKO 3137

en MURASE, Takashi

Search repository
HOSHINO, Shin

× HOSHINO, Shin

WEKO 3138

en HOSHINO, Shin

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HAYASAKA, Shizu

× HAYASAKA, Shizu

WEKO 3139

en HAYASAKA, Shizu

Search repository
OISO, Yutaka

× OISO, Yutaka

WEKO 3140

en OISO, Yutaka

Search repository
MURATA, Yoshiharu

× MURATA, Yoshiharu

WEKO 3141

en MURATA, Yoshiharu

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 hyponatremia
キーワード
主題Scheme Other
主題 demyelination
キーワード
主題Scheme Other
主題 blood-brain barrier
抄録
内容記述 Central pontine myelinolysis is a serious human demyelinative disorder commonly associated with rapid correction of hyponatremia. Although its precise etiology remains unclear, the blood-brain barrier (BBB) disruption following rapid increase in serum Na^+ considered having an important role in the process. In the present study, therefore, we investigated the preventive effects of various drugs that have been reported to affect the BBB permeability, on osmotic demyelination induced by rapid correction of hyponatremia in mice. Hyponatremia was induced by liquid diet feeding and subcutaneous infusion of l-deamino-8-D-arginine vasopressin, a vasopressin V2 receptor agonist. After 3 days, serum Na^+ was rapidly corrected with hypertonic saline injection. The following drugs were given subcutaneously just before and 5 hours after the correction. Mice in the control group showed serious neurological impairments and most of them died after the correction. Brain sections revealed marked demyelinative lesions in various areas of the brain. However, in the mice treated with aminoguanidine or 7-nitroindazole, a nitric oxide synthase inhibitor, neurological impairments were improved and the survival rates for 24 hours after the correction were markedly increased. Indomethacin, cimetidine and dexamethasone also increased the survival rates after rapid correction. Results from the present study suggest that these drugs may be useful in the prevention of osmotic demyelination after rapid correction of hyponatremia.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 国立情報学研究所で電子化したコンテンツを使用している。
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Research Institute of Environmental Medicine, Nagoya University
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/envm.46.58
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 02870517
書誌情報 en : Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University

巻 46, 号 1/2, p. 58-61, 発行日 2002-12
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/2784
識別子タイプ HDL
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