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  1. F100 環境医学研究所
  2. F100b 紀要
  3. Environmental medicine : annual report of the Research Institute of Environmental Medicine
  4. 46(1-2)

Increased Expression of mRNA for B1 and B2 Bradykinin Receptors in the Skin of Adjuvant Inoculated Rats

https://doi.org/10.18999/envm.46.70
https://doi.org/10.18999/envm.46.70
8cc81588-b67a-4275-8efd-0ec9da591f19
名前 / ファイル ライセンス アクション
KJ00000034867.pdf KJ00000034867.pdf (671.2 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2006-01-05
タイトル
タイトル Increased Expression of mRNA for B1 and B2 Bradykinin Receptors in the Skin of Adjuvant Inoculated Rats
言語 en
著者 UENO, Tomoyuki

× UENO, Tomoyuki

WEKO 3153

en UENO, Tomoyuki

Search repository
KOZAKI, Yasuko

× KOZAKI, Yasuko

WEKO 3154

en KOZAKI, Yasuko

Search repository
MIZUMURA, Kazue

× MIZUMURA, Kazue

WEKO 3155

en MIZUMURA, Kazue

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 bradykinin
キーワード
主題Scheme Other
主題 B1 bradykinin receptor
キーワード
主題Scheme Other
主題 B2 bradykinin receptor
キーワード
主題Scheme Other
主題 mRNA expression
キーワード
主題Scheme Other
主題 arthritic rat
抄録
内容記述 Bradykinin is the most established endogenous algesic substance. It has two receptors subtypes, B1 and B2, which are classified based on their pharmacological properties. It is generally accepted that the B2 receptor (B2R) is normally expressed in many tissues, whereas the B1 receptor (B1R) exists only in limited tissues and is synthesized de novo following tissue injury. We recently demonstrated that B2R-mediated bradykinin responses of peripheral nociceptors were increased in skin-saphenous nerve preparations in vitro in adjuvant inflamed rats, but involvement of B1R could not be confirmed. To examine the possibility that B1R is expressed in cells other than neurons and that we missed BIR-mediated responses while using in vitro preparations, we evaluated the mRNA expression of B1R in rat hind-paw skin and compared it with that of B2R after adjuvant inoculation. B2R mRNA was expressed in control and inflamed animals, and the level of its expression was increased 3 weeks after adjuvant inoculation. B1R mRNA, in contrast to the general belief, was expressed in control animals and increased 3 weeks after adjuvant inoculation, similar to B2R mRNA. Possible meanings of this finding are discussed.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 国立情報学研究所で電子化したコンテンツを使用している。
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Research Institute of Environmental Medicine, Nagoya University
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/envm.46.70
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 02870517
書誌情報 en : Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University

巻 46, 号 1/2, p. 70-73, 発行日 2002-12
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/2787
識別子タイプ HDL
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