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Voltage-Dependent Effects of Bepridil on D540K HERG Channels
https://doi.org/10.18999/envm.46.101
65c94dfc-f4be-41a5-b836-33ab7a42ac3d
名前 / ファイル | ライセンス | アクション | |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2006-01-05 | |||||
タイトル | ||||||
タイトル | Voltage-Dependent Effects of Bepridil on D540K HERG Channels | |||||
著者 |
NIWA, Ryoko
× NIWA, Ryoko× LU, Zhibo× HONJO, Haruo× KAMIYA, Kaichiro |
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キーワード | ||||||
主題Scheme | Other | |||||
主題 | bepridil | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | potassium channels | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | arrhythmia | |||||
抄録 | ||||||
内容記述 | To address the question of whether depolarization or channel opening facilitates drug binding, we studied the voltage- dependent block by bepridil, a positively charged drug, on D540K HERG channels expressed in Xenopus oocytes. At 0 mV, bepridil caused a concentration-dependent inhibition of D540K HERG current with IC_<50>s of 11 ± 3 μM (n=6). At -150 mV, inhibition by bepridil was decreased by 15-fold (161 ±31 μM, n=3). These results suggest that 1) membrane depolarization facilitates block of HERG channels; 2) binding of positively charged drug is augmented at depolarization and diminished at hyperpolarization if the channel remains open. | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | 国立情報学研究所で電子化したコンテンツを使用している。 | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
出版者 | Research Institute of Environmental Medicine, Nagoya University | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.18999/envm.46.101 | |||||
ID登録タイプ | JaLC | |||||
ISSN(print) | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 02870517 | |||||
書誌情報 |
Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University 巻 46, 号 1/2, p. 101-102, 発行日 2002-12 |
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フォーマット | ||||||
application/pdf | ||||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/2798 | |||||
識別子タイプ | HDL |