ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "34f50114-81b7-4153-9c07-ec34ed2cf97b"}, "_deposit": {"id": "1388", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "1388"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00001388", "sets": []}, "author_link": ["3202", "3203", "3204", "3205"], "item_1615768549627": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_9_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2002-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1/2", "bibliographicPageEnd": "102", "bibliographicPageStart": "101", "bibliographicVolumeNumber": "46", "bibliographic_titles": [{"bibliographic_title": "Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University", "bibliographic_titleLang": "en"}]}]}, "item_9_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "To address the question of whether depolarization or channel opening facilitates drug binding, we studied the voltage- dependent block by bepridil, a positively charged drug, on D540K HERG channels expressed in Xenopus oocytes. At 0 mV, bepridil caused a concentration-dependent inhibition of D540K HERG current with IC_\u003c50\u003es of 11 ± 3 μM (n=6). At -150 mV, inhibition by bepridil was decreased by 15-fold (161 ±31 μM, n=3). These results suggest that 1) membrane depolarization facilitates block of HERG channels; 2) binding of positively charged drug is augmented at depolarization and diminished at hyperpolarization if the channel remains open.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_9_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "国立情報学研究所で電子化したコンテンツを使用している。", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_9_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/2798"}]}, "item_9_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/envm.46.101", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Research Institute of Environmental Medicine, Nagoya University", "subitem_publisher_language": "en"}]}, "item_9_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_9_source_id_7": {"attribute_name": "ISSN(print)", "attribute_value_mlt": [{"subitem_source_identifier": "02870517", "subitem_source_identifier_type": "PISSN"}]}, "item_9_text_14": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_text_value": "application/pdf"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "NIWA, Ryoko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3202", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "LU, Zhibo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3203", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "HONJO, Haruo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3204", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KAMIYA, Kaichiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "3205", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00000034878.pdf", "filesize": [{"value": "215.6 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 215600.0, "url": {"label": "KJ00000034878.pdf", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/1388/files/KJ00000034878.pdf"}, "version_id": "0e949721-aa55-47c9-8799-38418bb3d12e"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "bepridil", "subitem_subject_scheme": "Other"}, {"subitem_subject": "potassium channels", "subitem_subject_scheme": "Other"}, {"subitem_subject": "arrhythmia", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Voltage-Dependent Effects of Bepridil on D540K HERG Channels", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Voltage-Dependent Effects of Bepridil on D540K HERG Channels", "subitem_title_language": "en"}]}, "item_type_id": "9", "owner": "1", "path": ["335"], "permalink_uri": "https://doi.org/10.18999/envm.46.101", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2006-01-05"}, "publish_date": "2006-01-05", "publish_status": "0", "recid": "1388", "relation": {}, "relation_version_is_last": true, "title": ["Voltage-Dependent Effects of Bepridil on D540K HERG Channels"], "weko_shared_id": -1}
  1. F100 環境医学研究所
  2. F100b 紀要
  3. Environmental medicine : annual report of the Research Institute of Environmental Medicine
  4. 46(1-2)

Voltage-Dependent Effects of Bepridil on D540K HERG Channels

https://doi.org/10.18999/envm.46.101
https://doi.org/10.18999/envm.46.101
65c94dfc-f4be-41a5-b836-33ab7a42ac3d
名前 / ファイル ライセンス アクション
KJ00000034878.pdf KJ00000034878.pdf (215.6 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2006-01-05
タイトル
タイトル Voltage-Dependent Effects of Bepridil on D540K HERG Channels
言語 en
著者 NIWA, Ryoko

× NIWA, Ryoko

WEKO 3202

en NIWA, Ryoko

Search repository
LU, Zhibo

× LU, Zhibo

WEKO 3203

en LU, Zhibo

Search repository
HONJO, Haruo

× HONJO, Haruo

WEKO 3204

en HONJO, Haruo

Search repository
KAMIYA, Kaichiro

× KAMIYA, Kaichiro

WEKO 3205

en KAMIYA, Kaichiro

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 bepridil
キーワード
主題Scheme Other
主題 potassium channels
キーワード
主題Scheme Other
主題 arrhythmia
抄録
内容記述 To address the question of whether depolarization or channel opening facilitates drug binding, we studied the voltage- dependent block by bepridil, a positively charged drug, on D540K HERG channels expressed in Xenopus oocytes. At 0 mV, bepridil caused a concentration-dependent inhibition of D540K HERG current with IC_<50>s of 11 ± 3 μM (n=6). At -150 mV, inhibition by bepridil was decreased by 15-fold (161 ±31 μM, n=3). These results suggest that 1) membrane depolarization facilitates block of HERG channels; 2) binding of positively charged drug is augmented at depolarization and diminished at hyperpolarization if the channel remains open.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 国立情報学研究所で電子化したコンテンツを使用している。
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Research Institute of Environmental Medicine, Nagoya University
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/envm.46.101
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 02870517
書誌情報 en : Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University

巻 46, 号 1/2, p. 101-102, 発行日 2002-12
フォーマット
application/pdf
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/2798
識別子タイプ HDL
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 21:38:02.360748
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3