{"_buckets": {"deposit": "7f1ab6d3-d4b2-4fbf-b17d-1d979356bd80"}, "_deposit": {"id": "1389", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "1389"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00001389", "sets": ["335"]}, "item_9_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2002-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1/2", "bibliographicPageEnd": "105", "bibliographicPageStart": "103", "bibliographicVolumeNumber": "46", "bibliographic_titles": [{"bibliographic_title": "Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University"}]}]}, "item_9_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Spiral-type reentry is crucial for genesis and maintenance of the life-threatening ventricular tachyarrhythmia, but little information is available for its pharmacological control. We examined the effects of pilsicainide (Pil), an antiarrhythmic drug having a specific Na^+ channel blocking action, on the spiral dynamics during ventricular tachycardia (VT). Optical action potential signals were recorded with the aid of a voltage-sensitive dye from the epicardial ventricular surface of rabbit heart perfused in-vitro. The endocardial side of the left ventricule was cryoablated to prepare 2-D subepicardial ventricular muscle layers. A high-resolution video-imaging system combined with fiber optic probes was employed for signal recordings. Pil (3 μM) caused a significant reduction of conduction velocity under basal stimulation (SI, 2.5 Hz) without affecting action potential duration. Ventricular tachycardia (VT) induced by cross-field stimulation (S2, 20 V) in the presence of Pil were characterized by slower cycle length (by 22.7 %) and longer electrical diastole (by 107.2 %) compared with controls. Pil also caused an enlargement of core area in stational spiral-type excitation. Possible mechanisms involved in the modulation of spiral-type reentry in the ventricle are discussed.", "subitem_description_type": "Abstract"}]}, "item_9_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "国立情報学研究所で電子化したコンテンツを使用している。", "subitem_description_type": "Other"}]}, "item_9_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/2799"}]}, "item_9_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/envm.46.103", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Research Institute of Environmental Medicine, Nagoya University"}]}, "item_9_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_9_source_id_7": {"attribute_name": "ISSN（print）", "attribute_value_mlt": [{"subitem_source_identifier": "02870517", "subitem_source_identifier_type": "ISSN"}]}, "item_9_text_14": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_text_value": "application/pdf"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "NIHEI, Motoki"}], "nameIdentifiers": [{"nameIdentifier": "3206", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "YAMAMOTO, Mitsuru"}], "nameIdentifiers": [{"nameIdentifier": "3207", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "NIWA, Ryoko"}], "nameIdentifiers": [{"nameIdentifier": "3208", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ARAFUNE, Tatsuhiko"}], "nameIdentifiers": [{"nameIdentifier": "3209", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "MISHIMA, Akira"}], "nameIdentifiers": [{"nameIdentifier": "3210", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "SHIBATA, Nitaro"}], "nameIdentifiers": [{"nameIdentifier": "3211", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "SAKUMA, Ichiro"}], "nameIdentifiers": [{"nameIdentifier": "3212", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "INADA, Hiroshi"}], "nameIdentifiers": [{"nameIdentifier": "3213", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "HONJO, Haruo"}], "nameIdentifiers": [{"nameIdentifier": "3214", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KAMIYA, Kaichiro"}], "nameIdentifiers": [{"nameIdentifier": "3215", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KODAMA, Itsuo"}], "nameIdentifiers": [{"nameIdentifier": "3216", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00000034879.pdf", "filesize": [{"value": "475.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 475700.0, "url": {"label": "KJ00000034879.pdf", "url": "https://nagoya.repo.nii.ac.jp/record/1389/files/KJ00000034879.pdf"}, "version_id": "2f05cca5-a0f9-4d6c-81db-a3457bafaa03"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "arrhythmia", "subitem_subject_scheme": "Other"}, {"subitem_subject": "spiral-reentry", "subitem_subject_scheme": "Other"}, {"subitem_subject": "sodium channel", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Na^+ Channel Blockade Causes a Prolongation of Electrical Diastole during Spiral-type Reentry in the Ventricle", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Na^+ Channel Blockade Causes a Prolongation of Electrical Diastole during Spiral-type Reentry in the Ventricle"}]}, "item_type_id": "9", "owner": "1", "path": ["335"], "permalink_uri": "https://doi.org/10.18999/envm.46.103", "pubdate": {"attribute_name": "公開日", "attribute_value": "2006-01-05"}, "publish_date": "2006-01-05", "publish_status": "0", "recid": "1389", "relation": {}, "relation_version_is_last": true, "title": ["Na^+ Channel Blockade Causes a Prolongation of Electrical Diastole during Spiral-type Reentry in the Ventricle"], "weko_shared_id": null}