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Na^+ Channel Blockade Causes a Prolongation of Electrical Diastole during Spiral-type Reentry in the Ventricle
https://doi.org/10.18999/envm.46.103
https://doi.org/10.18999/envm.46.1039bfca988-b540-44d3-b615-5ec541eea50b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00000034879.pdf (475.7 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-01-05 | |||||
| タイトル | ||||||
| タイトル | Na^+ Channel Blockade Causes a Prolongation of Electrical Diastole during Spiral-type Reentry in the Ventricle | |||||
| 言語 | en | |||||
| 著者 |
NIHEI, Motoki
× NIHEI, Motoki× YAMAMOTO, Mitsuru× NIWA, Ryoko× ARAFUNE, Tatsuhiko× MISHIMA, Akira× SHIBATA, Nitaro× SAKUMA, Ichiro× INADA, Hiroshi× HONJO, Haruo× KAMIYA, Kaichiro× KODAMA, Itsuo |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | arrhythmia | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | spiral-reentry | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | sodium channel | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Spiral-type reentry is crucial for genesis and maintenance of the life-threatening ventricular tachyarrhythmia, but little information is available for its pharmacological control. We examined the effects of pilsicainide (Pil), an antiarrhythmic drug having a specific Na^+ channel blocking action, on the spiral dynamics during ventricular tachycardia (VT). Optical action potential signals were recorded with the aid of a voltage-sensitive dye from the epicardial ventricular surface of rabbit heart perfused in-vitro. The endocardial side of the left ventricule was cryoablated to prepare 2-D subepicardial ventricular muscle layers. A high-resolution video-imaging system combined with fiber optic probes was employed for signal recordings. Pil (3 μM) caused a significant reduction of conduction velocity under basal stimulation (SI, 2.5 Hz) without affecting action potential duration. Ventricular tachycardia (VT) induced by cross-field stimulation (S2, 20 V) in the presence of Pil were characterized by slower cycle length (by 22.7 %) and longer electrical diastole (by 107.2 %) compared with controls. Pil also caused an enlargement of core area in stational spiral-type excitation. Possible mechanisms involved in the modulation of spiral-type reentry in the ventricle are discussed. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 国立情報学研究所で電子化したコンテンツを使用している。 | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | Research Institute of Environmental Medicine, Nagoya University | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/envm.46.103 | |||||
| ID登録タイプ | JaLC | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 02870517 | |||||
| 書誌情報 |
en : Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University 巻 46, 号 1/2, p. 103-105, 発行日 2002-12 |
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| フォーマット | ||||||
| 値 | application/pdf | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/2799 | |||||
| 識別子タイプ | HDL | |||||
