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CELL CYCLE-DEPENDENT LOCALIZATION OF TISSUE INHIBITOR OF METALLOPROTEINASES-1 IMMUNOREACTIVITY IN CULTURED HUMAN GINGIVAL FIBROBLASTS
https://doi.org/10.18999/nagjms.58.3-4.133
https://doi.org/10.18999/nagjms.58.3-4.1332697e6c2-ac4a-4026-82cb-c3a09f8d798e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
v58n34p133_142.pdf (1.2 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-03-08 | |||||
| タイトル | ||||||
| タイトル | CELL CYCLE-DEPENDENT LOCALIZATION OF TISSUE INHIBITOR OF METALLOPROTEINASES-1 IMMUNOREACTIVITY IN CULTURED HUMAN GINGIVAL FIBROBLASTS | |||||
| 言語 | en | |||||
| 著者 |
LI, HANG
× LI, HANG× NISHIO, KOJI× YAMASHITA, KYOKO× HAYAKAWA, TARO× HOSHINO, TAKESHI |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | TIMP-1 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Human gingival fibroblast | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Nuclear localization | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cell cycle | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Localization of the tissue inhibitor of metalloproteinases-1 (TIMP-1) was investigated in cultured human gingival fibroblasts by immunohistochemistry. TIMP-1 immunostaining was observed in the cytoplasm of a majority of cells, and in the nucleus of some cells. Depletion of fetal calf serum (FCS) from the culture medium reduced the density of immunoreactive TIMP-1 in the nucleus more remarkably than in the cytoplasm, and the following FCS-induced cell growth was accompanied by a recovery of immuno-reactive TIMP-1 in both the nucleus and the cytoplasm. The frequency of the nuclear TIMP-1-positive cells changed in line with that of PCNA-positive cells and was always much higher than that of S-phase cells, which were estimated by a pulse labelled 5-Bromo-2' deoxyuridine (BrdU). These results suggest a localization of TIMP-1 or a related substance in the nucleus of proliferating human fibroblasts, and its depletion from the nucleus due to an arrest of cell growth. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.58.3-4.133 | |||||
| ID登録タイプ | JaLC | |||||
| 関連情報 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/5834/5834.html | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 58, 号 3-4, p. 133-142, 発行日 1995-12-25 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/16089 | |||||
| 識別子タイプ | HDL | |||||
