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A correlative immuno-light and electron microscopic study on the type I collagen in the bone morphogenetic protein-induced cartilage
http://hdl.handle.net/2237/16358
http://hdl.handle.net/2237/16358977e2197-b2b0-4077-b995-922403a68b9c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
k2909.pdf (2.3 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-05-10 | |||||
| タイトル | ||||||
| タイトル | A correlative immuno-light and electron microscopic study on the type I collagen in the bone morphogenetic protein-induced cartilage | |||||
| 言語 | en | |||||
| 著者 |
Hattori, Hisashi
× Hattori, Hisashi× Kawai, Michio× Yasue, Kazuki× Mizutani, Hideki× Kobayashi, Miya× Kaneda, Toshio× Hoshino, Takeshi |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Journal of Electron Microscopy following peer review. The definitive publisher-authenticated version Journal of Electron Microscopy. v.42, n.6, 1993, p.400-406 is available online at: http://jmicro.oxfordjournals.org/content/42/6/400.abstract. | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | bone morphogenetic protein | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | hypertrophic chondrocyte | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | immunoelectron microscopy | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | type I collagen | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Bone morphogenetic protein (BMP) partially purified from bovine bone was implanted into the thigh muscles of AKR-strain mice to induce an ectopic endochondral ossification tissue. The extracellular matrix components around the hypertrophic chondrocytes in the induced tissue were examined by electron microscopy and immunohistochemistry for type I collagen. At 14 days after implantation, chondrocytes became hypertrophic with calcifying matrix around them. Some hypertrophic chondrocytes showed no degenerative appearances. They were ringed by a pericellular matrix with no metachromasia which was distinct from the metachromatic cartilage matrix. The localization of type I collagen was demonstrated by immuno-staining in this matrix. Ultrastructurally, ring-shaped matrix consisted of interwoven collagen fibrils on which a D-periodic banding pattern could be discerned. Immunoelectron microscopy demonstrated immunoreactivity of type I collagen on these fibrils. These results suggest that some of the BMP-induced hypertrophic chondrocytes maintain their activity and produce type I collagen-rich matrix before their lacunae are eroded. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成6年3月25日 服部宇氏の博士論文として提出された | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | Oxford University Press | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_db06 | |||||
| タイプ | doctoral thesis | |||||
| 関連情報 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://jmicro.oxfordjournals.org/content/42/6/400.abstract | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0022-0744 | |||||
| 書誌情報 |
en : Journal of Electron Microscopy 巻 42, 号 6, p. 400-406, 発行日 1993-12 |
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| 学位名 | ||||||
| 言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 13901 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | 名古屋大学 | |||||
| 言語 | en | |||||
| 学位授与機関名 | NAGOYA University | |||||
| 学位授与年度 | ||||||
| 学位授与年度 | 1993 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 1993-12-01 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第2909号 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://jmicro.oxfordjournals.org/content/42/6/400.abstract | |||||
| 識別子タイプ | URI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/16358 | |||||
| 識別子タイプ | HDL | |||||
