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  1. C100 医学部/医学系研究科
  2. C100d 学位論文
  3. 博士論文(医博・論医博)

A correlative immuno-light and electron microscopic study on the type I collagen in the bone morphogenetic protein-induced cartilage

http://hdl.handle.net/2237/16358
http://hdl.handle.net/2237/16358
977e2197-b2b0-4077-b995-922403a68b9c
名前 / ファイル ライセンス アクション
k2909.pdf k2909.pdf (2.3 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2012-05-10
タイトル
タイトル A correlative immuno-light and electron microscopic study on the type I collagen in the bone morphogenetic protein-induced cartilage
言語 en
著者 Hattori, Hisashi

× Hattori, Hisashi

WEKO 44754

en Hattori, Hisashi

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Kawai, Michio

× Kawai, Michio

WEKO 44755

en Kawai, Michio

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Yasue, Kazuki

× Yasue, Kazuki

WEKO 44756

en Yasue, Kazuki

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Mizutani, Hideki

× Mizutani, Hideki

WEKO 44757

en Mizutani, Hideki

Search repository
Kobayashi, Miya

× Kobayashi, Miya

WEKO 44758

en Kobayashi, Miya

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Kaneda, Toshio

× Kaneda, Toshio

WEKO 44759

en Kaneda, Toshio

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Hoshino, Takeshi

× Hoshino, Takeshi

WEKO 44760

en Hoshino, Takeshi

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Journal of Electron Microscopy following peer review. The definitive publisher-authenticated version Journal of Electron Microscopy. v.42, n.6, 1993, p.400-406 is available online at: http://jmicro.oxfordjournals.org/content/42/6/400.abstract.
キーワード
主題Scheme Other
主題 bone morphogenetic protein
キーワード
主題Scheme Other
主題 hypertrophic chondrocyte
キーワード
主題Scheme Other
主題 immunoelectron microscopy
キーワード
主題Scheme Other
主題 type I collagen
抄録
内容記述 Bone morphogenetic protein (BMP) partially purified from bovine bone was implanted into the thigh muscles of AKR-strain mice to induce an ectopic endochondral ossification tissue. The extracellular matrix components around the hypertrophic chondrocytes in the induced tissue were examined by electron microscopy and immunohistochemistry for type I collagen. At 14 days after implantation, chondrocytes became hypertrophic with calcifying matrix around them. Some hypertrophic chondrocytes showed no degenerative appearances. They were ringed by a pericellular matrix with no metachromasia which was distinct from the metachromatic cartilage matrix. The localization of type I collagen was demonstrated by immuno-staining in this matrix. Ultrastructurally, ring-shaped matrix consisted of interwoven collagen fibrils on which a D-periodic banding pattern could be discerned. Immunoelectron microscopy demonstrated immunoreactivity of type I collagen on these fibrils. These results suggest that some of the BMP-induced hypertrophic chondrocytes maintain their activity and produce type I collagen-rich matrix before their lacunae are eroded.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成6年3月25日 服部宇氏の博士論文として提出された
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Oxford University Press
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://jmicro.oxfordjournals.org/content/42/6/400.abstract
ISSN
収録物識別子タイプ PISSN
収録物識別子 0022-0744
書誌情報 en : Journal of Electron Microscopy

巻 42, 号 6, p. 400-406, 発行日 1993-12
学位名
言語 ja
学位名 博士(医学)
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 13901
言語 ja
学位授与機関名 名古屋大学
言語 en
学位授与機関名 NAGOYA University
学位授与年度
学位授与年度 1993
学位授与年月日
学位授与年月日 1993-12-01
学位授与番号
学位授与番号 甲第2909号
著者版フラグ
値 publisher
URI
識別子 http://jmicro.oxfordjournals.org/content/42/6/400.abstract
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/16358
識別子タイプ HDL
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