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  1. C100 医学部/医学系研究科
  2. C100d 学位論文
  3. 博士論文(医博・論医博)

A New Model for Pancreaticobiliary Maljunction without Bile Duct Dilatation: Demonstration of Cell Proliferation in the Gallbladder Epithelium

http://hdl.handle.net/2237/16712
http://hdl.handle.net/2237/16712
448ce7d0-bed2-414e-b71c-2ce4b72efd9c
名前 / ファイル ライセンス アクション
k3182.pdf k3182.pdf (5.0 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2012-08-20
タイトル
タイトル A New Model for Pancreaticobiliary Maljunction without Bile Duct Dilatation: Demonstration of Cell Proliferation in the Gallbladder Epithelium
言語 en
著者 Kaneko, Kenitiro

× Kaneko, Kenitiro

WEKO 45628

en Kaneko, Kenitiro

Search repository
Ando, Hisami

× Ando, Hisami

WEKO 45629

en Ando, Hisami

Search repository
Umeda, Takashi

× Umeda, Takashi

WEKO 45630

en Umeda, Takashi

Search repository
Murahashi, Osamu

× Murahashi, Osamu

WEKO 45631

en Murahashi, Osamu

Search repository
Hiraiwa, Katsumasa

× Hiraiwa, Katsumasa

WEKO 45632

en Hiraiwa, Katsumasa

Search repository
Niimi, Norihiro

× Niimi, Norihiro

WEKO 45633

en Niimi, Norihiro

Search repository
Hossain, Moazzem

× Hossain, Moazzem

WEKO 45634

en Hossain, Moazzem

Search repository
Ito, Takahiro

× Ito, Takahiro

WEKO 45635

en Ito, Takahiro

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is the author's version of a work that was accepted for publication in Journal of Surgical Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms, may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Surgical Research. v.60, n.1, 1996, p.115–121 http://dx.doi.org/10.1006/jsre.1996.0019
キーワード
主題Scheme Other
主題 Choledochal cyst
キーワード
主題Scheme Other
主題 Bile ducts
キーワード
主題Scheme Other
主題 Pancreatic ducts
キーワード
主題Scheme Other
主題 Gallbladder neoplasms
キーワード
主題Scheme Other
主題 Cell cycle
キーワード
主題Scheme Other
主題 PCNA
抄録
内容記述 Patients with pancreaticobiliary maljunction without bile duct dilatation (PBMWBDD) develop gallbladder carcinoma frequently. No models of PBMWBDD exist, and no previous studies have clearly demonstrated changes in the gallbladder relating to carcinogenesis. We, therefore, examined the cell kinetics of the gallbladder epithelium in a new experimental model of PBMWBDD. A cat model was produced by performing choledocho-pancreatic side-to-side ductal anastomosis in nine animals. Five cats, in which the choledocho-pancreatic ducts were exposed only, served as controls. After 6 months, the gallbladders of these cats were removed and stained with anti-proliferating cell nuclear antigen (PCNA) antibody (PC10, Dako). The labeling index (LI) was determined from the percentage of positive nuclei in three microscopic fields. The diameter of the common bile duct was not different between the models and the controls. In the models, the number of PCNA positive cells was significantly increased. The mean (± standard deviation) PCNA LI was 28.1 ± 12.2% in the models and 4.3 ± 1.6% in the controls (P< 0.01). These studies clearly indicate that this model is suitable for studying PBMWBDD and that PBMWBDD has a prominent proliferating effect on the gallbladder epithelium which may play an important role in gallbladder carcinogenesis.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成7年3月27日 金子健一朗氏の博士論文として提出された
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1006/jsre.1996.0019
ISSN
収録物識別子タイプ PISSN
収録物識別子 0022-4804
書誌情報 en : Journal of Surgical Research

巻 60, 号 1, p. 115-121, 発行日 1996-01
学位名
言語 ja
学位名 博士(医学)
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 13901
言語 ja
学位授与機関名 名古屋大学
言語 en
学位授与機関名 NAGOYA University
学位授与年度
学位授与年度 1995
学位授与年月日
学位授与年月日 1996-01-01
学位授与番号
学位授与番号 甲第3182号
著者版フラグ
値 publisher
URI
識別子 http://dx.doi.org/10.1006/jsre.1996.0019
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/16712
識別子タイプ HDL
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