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A New Model for Pancreaticobiliary Maljunction without Bile Duct Dilatation: Demonstration of Cell Proliferation in the Gallbladder Epithelium
http://hdl.handle.net/2237/16712
http://hdl.handle.net/2237/16712448ce7d0-bed2-414e-b71c-2ce4b72efd9c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
k3182.pdf (5.0 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-08-20 | |||||
| タイトル | ||||||
| タイトル | A New Model for Pancreaticobiliary Maljunction without Bile Duct Dilatation: Demonstration of Cell Proliferation in the Gallbladder Epithelium | |||||
| 言語 | en | |||||
| 著者 |
Kaneko, Kenitiro
× Kaneko, Kenitiro× Ando, Hisami× Umeda, Takashi× Murahashi, Osamu× Hiraiwa, Katsumasa× Niimi, Norihiro× Hossain, Moazzem× Ito, Takahiro |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | This is the author's version of a work that was accepted for publication in Journal of Surgical Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms, may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Surgical Research. v.60, n.1, 1996, p.115–121 http://dx.doi.org/10.1006/jsre.1996.0019 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Choledochal cyst | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Bile ducts | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Pancreatic ducts | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Gallbladder neoplasms | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cell cycle | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | PCNA | |||||
| 抄録 | ||||||
| 内容記述 | Patients with pancreaticobiliary maljunction without bile duct dilatation (PBMWBDD) develop gallbladder carcinoma frequently. No models of PBMWBDD exist, and no previous studies have clearly demonstrated changes in the gallbladder relating to carcinogenesis. We, therefore, examined the cell kinetics of the gallbladder epithelium in a new experimental model of PBMWBDD. A cat model was produced by performing choledocho-pancreatic side-to-side ductal anastomosis in nine animals. Five cats, in which the choledocho-pancreatic ducts were exposed only, served as controls. After 6 months, the gallbladders of these cats were removed and stained with anti-proliferating cell nuclear antigen (PCNA) antibody (PC10, Dako). The labeling index (LI) was determined from the percentage of positive nuclei in three microscopic fields. The diameter of the common bile duct was not different between the models and the controls. In the models, the number of PCNA positive cells was significantly increased. The mean (± standard deviation) PCNA LI was 28.1 ± 12.2% in the models and 4.3 ± 1.6% in the controls (P< 0.01). These studies clearly indicate that this model is suitable for studying PBMWBDD and that PBMWBDD has a prominent proliferating effect on the gallbladder epithelium which may play an important role in gallbladder carcinogenesis. | |||||
| 言語 | en | |||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | ||||||
| 内容記述 | 名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成7年3月27日 金子健一朗氏の博士論文として提出された | |||||
| 言語 | ja | |||||
| 内容記述タイプ | Other | |||||
| 出版者 | ||||||
| 言語 | en | |||||
| 出版者 | Elsevier | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_db06 | |||||
| タイプ | doctoral thesis | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1006/jsre.1996.0019 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0022-4804 | |||||
| 書誌情報 |
en : Journal of Surgical Research 巻 60, 号 1, p. 115-121, 発行日 1996-01 |
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| 学位名 | ||||||
| 言語 | ja | |||||
| 学位名 | 博士(医学) | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 13901 | |||||
| 言語 | ja | |||||
| 学位授与機関名 | 名古屋大学 | |||||
| 言語 | en | |||||
| 学位授与機関名 | NAGOYA University | |||||
| 学位授与年度 | ||||||
| 学位授与年度 | 1995 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 1996-01-01 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第3182号 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://dx.doi.org/10.1006/jsre.1996.0019 | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/16712 | |||||
| 識別子タイプ | HDL | |||||
