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Determinants of left ventricular filling dynamics: alteration in the Doppler-derived transmitral filling profile with progressive impairment of cardiac function in a dog preparation
http://hdl.handle.net/2237/16725
http://hdl.handle.net/2237/1672568d4407b-3e92-4789-9aea-b891bebfbb62
名前 / ファイル | ライセンス | アクション |
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o4225.pdf (4.9 MB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2012-08-24 | |||||
タイトル | ||||||
タイトル | Determinants of left ventricular filling dynamics: alteration in the Doppler-derived transmitral filling profile with progressive impairment of cardiac function in a dog preparation | |||||
言語 | en | |||||
著者 |
MIYAGUCHI, K.
× MIYAGUCHI, K.× OGAWA, S.× NOMURA, H.× IWASE, M.× YOKOTA, M.× HAYASHI, H. |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | This is a pre-copy-editing, author-produced PDF of an article accepted for publication in European heart journal following peer review. The definitive publisher-authenticated version European heart journal. v.13, n.6, 1992, p.832-839 is available online at: http://eurheartj.oxfordjournals.org/content/13/6/832.abstract | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pulsed Doppler echocardiography | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | transmitral filling | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | diastolic property | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | loading condition | |||||
抄録 | ||||||
内容記述 | To clarify the factors determining transmitral filling, left ventricular and atrial pressures (LVP and LAP) and Doppler-derived diastolic indices were analysed in six anaesthetized dogs at various right atrial pacing rates during dextran infusion. The relationship of the late to early diastolic peak velocity ratio (A/E ratio) to end-diastolic LVP (LVEDP) showed a quadratic curve concave to the LVEDP axis in five animals (r2= 0.320–0.588). An elevation in LVEDP up to 25 mmHg accompanied an increase in A/E ratio (ascending limb), and further LVEDP elevation caused its inverse decline (descending limb). Multiple regression analysis indicated that A/E ratio correlated positively with maximal L VP, a-wave LA P and heart rate, and negatively with v-wave LAP in both limbs. The time constant of isovolumic LVP decline, which was prolonged as LVEDP was elevated, was a positive correlate of A/E ratio in the ascending limb, but lost its influence on A/E ratio in the descending limb. An elevation in v-wave LAP must have masked the expected effect of left ventricular relaxation abnormality on A/E ratio in this limb. Thus, the transmitral filling profile did not alter unidirectionally, but returned to that seen before volume loading, with a simultaneous progressive impairment of cardiac function. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | 名古屋大学博士学位論文 学位の種類 : 医学博士(論文) 学位授与年月日:平成4年7月20日 宮口和彦氏の博士論文として提出された | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Oxford University Press | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_db06 | |||||
タイプ | doctoral thesis | |||||
関連情報 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | URI | |||||
関連識別子 | http://eurheartj.oxfordjournals.org/content/13/6/832.abstract | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0195-668X | |||||
書誌情報 |
en : European heart journal 巻 13, 号 6, p. 832-839, 発行日 1992-06 |
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学位名 | ||||||
言語 | ja | |||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 13901 | |||||
言語 | ja | |||||
学位授与機関名 | 名古屋大学 | |||||
言語 | en | |||||
学位授与機関名 | NAGOYA University | |||||
学位授与年度 | ||||||
学位授与年度 | 1992 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 1992-06-01 | |||||
学位授与番号 | ||||||
学位授与番号 | 乙第4225号 | |||||
著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/16725 | |||||
識別子タイプ | HDL |