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  1. C100 医学部/医学系研究科
  2. C100d 学位論文
  3. 博士論文(医博・論医博)

Determinants of left ventricular filling dynamics: alteration in the Doppler-derived transmitral filling profile with progressive impairment of cardiac function in a dog preparation

http://hdl.handle.net/2237/16725
68d4407b-3e92-4789-9aea-b891bebfbb62
名前 / ファイル ライセンス アクション
o4225.pdf o4225.pdf (4.9 MB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2012-08-24
タイトル
タイトル Determinants of left ventricular filling dynamics: alteration in the Doppler-derived transmitral filling profile with progressive impairment of cardiac function in a dog preparation
著者 MIYAGUCHI, K.

× MIYAGUCHI, K.

WEKO 45693

MIYAGUCHI, K.

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OGAWA, S.

× OGAWA, S.

WEKO 45694

OGAWA, S.

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NOMURA, H.

× NOMURA, H.

WEKO 45695

NOMURA, H.

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IWASE, M.

× IWASE, M.

WEKO 45696

IWASE, M.

Search repository
YOKOTA, M.

× YOKOTA, M.

WEKO 45697

YOKOTA, M.

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HAYASHI, H.

× HAYASHI, H.

WEKO 45698

HAYASHI, H.

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権利
権利情報 This is a pre-copy-editing, author-produced PDF of an article accepted for publication in European heart journal following peer review. The definitive publisher-authenticated version European heart journal. v.13, n.6, 1992, p.832-839 is available online at: http://eurheartj.oxfordjournals.org/content/13/6/832.abstract
キーワード
主題Scheme Other
主題 Pulsed Doppler echocardiography
キーワード
主題Scheme Other
主題 transmitral filling
キーワード
主題Scheme Other
主題 diastolic property
キーワード
主題Scheme Other
主題 loading condition
抄録
内容記述 To clarify the factors determining transmitral filling, left ventricular and atrial pressures (LVP and LAP) and Doppler-derived diastolic indices were analysed in six anaesthetized dogs at various right atrial pacing rates during dextran infusion. The relationship of the late to early diastolic peak velocity ratio (A/E ratio) to end-diastolic LVP (LVEDP) showed a quadratic curve concave to the LVEDP axis in five animals (r2= 0.320–0.588). An elevation in LVEDP up to 25 mmHg accompanied an increase in A/E ratio (ascending limb), and further LVEDP elevation caused its inverse decline (descending limb). Multiple regression analysis indicated that A/E ratio correlated positively with maximal L VP, a-wave LA P and heart rate, and negatively with v-wave LAP in both limbs. The time constant of isovolumic LVP decline, which was prolonged as LVEDP was elevated, was a positive correlate of A/E ratio in the ascending limb, but lost its influence on A/E ratio in the descending limb. An elevation in v-wave LAP must have masked the expected effect of left ventricular relaxation abnormality on A/E ratio in this limb. Thus, the transmitral filling profile did not alter unidirectionally, but returned to that seen before volume loading, with a simultaneous progressive impairment of cardiac function.
内容記述タイプ Abstract
内容記述
内容記述 名古屋大学博士学位論文 学位の種類 : 医学博士(論文) 学位授与年月日:平成4年7月20日 宮口和彦氏の博士論文として提出された
内容記述タイプ Other
出版者
出版者 Oxford University Press
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
ISSN
収録物識別子タイプ ISSN
収録物識別子 0195-668X
書誌情報 European heart journal

巻 13, 号 6, p. 832-839, 発行日 1992-06
学位授与年度
学位授与年度 1992
学位授与年月日
学位授与年月日 1992-06-01
著者版フラグ
値 publisher
URI
識別子 http://eurheartj.oxfordjournals.org/content/13/6/832.abstract
識別子タイプ URI
URI
識別子 乙4225
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/16725
識別子タイプ HDL
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