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Effects of Adrenergic and Cholinergic Agents and Leukotrienes on Mucociliary Transport Force Measured by Using Frog Palate
https://doi.org/10.18999/nagjms.49.1-4.21
https://doi.org/10.18999/nagjms.49.1-4.21cbb016fd-48b7-4692-92bc-114056fcb2dd
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
v49n14p21_30.pdf (559.9 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-02-13 | |||||
| タイトル | ||||||
| タイトル | Effects of Adrenergic and Cholinergic Agents and Leukotrienes on Mucociliary Transport Force Measured by Using Frog Palate | |||||
| 言語 | en | |||||
| 著者 |
YAMAKI, KENICHI
× YAMAKI, KENICHI× NODA, YASUNOBU× TAKAGI, KENZO× SATAKE, TATSUO |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | mucociliary transport force | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | isoproterenol | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | acetylcholine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | frog palate | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We have developed a new method to quantify the mucociliary transport force (MCTF). We validated the method by examining the effects of isoproterenol (Iso), norepinephrine (NE), epinephrine (Epi), and acetylcholine (ACh) on MCTF. In the first series of experiments, the effects of leukotrienes (LTs) on MCTF were investigated. In accordance with previous studies, Iso, NE, and ACh induced increases in MCTF, but Epi did not cause any significant effects. In the second series of experiments, LTC4 induced a significant increase in MCTF and LTD4 induced a significant decrease in MCTF, although these effects were transient. Neither LTB4 nor LTE4 affected MCTF. The effects of LTC4 and LTD4 were inhibited by a LT antagonist, FPL55712. These results indicate that we have developed a useful and sensitive method for quantitative determination of the immediate and direct effect of agonists on mucociliary transport, and that selective agonists may be involved in the defense mechanism of the lung to carry mucus plugs or locally produced debris out of the airways. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.49.1-4.21 | |||||
| ID登録タイプ | JaLC | |||||
| 関連情報 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/4914/4914.html | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 49, 号 1-4, p. 21-30, 発行日 1987-03 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/17495 | |||||
| 識別子タイプ | HDL | |||||
