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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 51(1-4)

Effects of Lipolytic and Antilipolytic Agents on Glycerol and Free Fatty Acid Release from Isolated Adipocytes of Normal and Diabetic Rats

https://doi.org/10.18999/nagjms.51.1-4.17
https://doi.org/10.18999/nagjms.51.1-4.17
bf8c9675-0502-4541-b0cf-5bc72ac33fbf
名前 / ファイル ライセンス アクション
v51n14p17_23.pdf v51n14p17_23.pdf (547.6 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-02-13
タイトル
タイトル Effects of Lipolytic and Antilipolytic Agents on Glycerol and Free Fatty Acid Release from Isolated Adipocytes of Normal and Diabetic Rats
著者 KAMEI, IZUMI

× KAMEI, IZUMI

WEKO 47223

KAMEI, IZUMI

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HOTTA, NIGISHI

× HOTTA, NIGISHI

WEKO 47224

HOTTA, NIGISHI

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KAKUTA, HIRONOBU

× KAKUTA, HIRONOBU

WEKO 47225

KAKUTA, HIRONOBU

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KIMURA, MASAO

× KIMURA, MASAO

WEKO 47226

KIMURA, MASAO

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FUKASAWA, HIDEO

× FUKASAWA, HIDEO

WEKO 47227

FUKASAWA, HIDEO

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KOH, NAOKI

× KOH, NAOKI

WEKO 47228

KOH, NAOKI

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SAKAMOTO, NOBUO

× SAKAMOTO, NOBUO

WEKO 47229

SAKAMOTO, NOBUO

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キーワード
主題Scheme Other
主題 β-Hydroxybutyrate
キーワード
主題Scheme Other
主題 Hyperosmolarity
キーワード
主題Scheme Other
主題 Insulin
キーワード
主題Scheme Other
主題 Isolated adipocytes
キーワード
主題Scheme Other
主題 Lipolytic and antilipolytic agents
抄録
内容記述 Isolated adipocytes from severely diabetic rats exhibited hypersensitivity to epinephrine at low concentrations (0.05-0.1μM) on lipolysis, compared with isolated adipocytes from normal and mildly diabetic rats. Hypersensitivity to dibutyryl cyclic AMP and theophylline at concentrations from 0.05 to 0.50mM was not observed in adipocytes of severely diabetic rats. Insulin could not exert an inhibitory effect on epinephrineinduced lipolysis in adipocytes of severely diabetic rats. In isolated adipocytes from normal rats, hyperosmolarity due to the combination of 50mM glucose and 100 mM sodium chloride only had an inhibitory effect on 0.25μM epinephrine-induced lipolysis. Ten mM β-hydroxybutyrate did not inhibit lipolysis caused by epinephrine although any lipolysis stimulated by epinephrine, dibutyryl cyclic AMP and theophylline was inhibited by insulin. Our present findings may partly explain insulin resistance in the severely diabetic state and the pathogenesis of the absence of ketosis in hyperglycemic hyperosmolar conditions.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.51.1-4.17
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 51, 号 1-4, p. 17-23, 発行日 1989-03
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/5114/5114.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/17507
識別子タイプ HDL
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