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Effects of Lipolytic and Antilipolytic Agents on Glycerol and Free Fatty Acid Release from Isolated Adipocytes of Normal and Diabetic Rats
https://doi.org/10.18999/nagjms.51.1-4.17
https://doi.org/10.18999/nagjms.51.1-4.17bf8c9675-0502-4541-b0cf-5bc72ac33fbf
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
v51n14p17_23.pdf (547.6 kB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-02-13 | |||||
| タイトル | ||||||
| タイトル | Effects of Lipolytic and Antilipolytic Agents on Glycerol and Free Fatty Acid Release from Isolated Adipocytes of Normal and Diabetic Rats | |||||
| 言語 | en | |||||
| 著者 |
KAMEI, IZUMI
× KAMEI, IZUMI× HOTTA, NIGISHI× KAKUTA, HIRONOBU× KIMURA, MASAO× FUKASAWA, HIDEO× KOH, NAOKI× SAKAMOTO, NOBUO |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | β-Hydroxybutyrate | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Hyperosmolarity | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Insulin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Isolated adipocytes | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Lipolytic and antilipolytic agents | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Isolated adipocytes from severely diabetic rats exhibited hypersensitivity to epinephrine at low concentrations (0.05-0.1μM) on lipolysis, compared with isolated adipocytes from normal and mildly diabetic rats. Hypersensitivity to dibutyryl cyclic AMP and theophylline at concentrations from 0.05 to 0.50mM was not observed in adipocytes of severely diabetic rats. Insulin could not exert an inhibitory effect on epinephrineinduced lipolysis in adipocytes of severely diabetic rats. In isolated adipocytes from normal rats, hyperosmolarity due to the combination of 50mM glucose and 100 mM sodium chloride only had an inhibitory effect on 0.25μM epinephrine-induced lipolysis. Ten mM β-hydroxybutyrate did not inhibit lipolysis caused by epinephrine although any lipolysis stimulated by epinephrine, dibutyryl cyclic AMP and theophylline was inhibited by insulin. Our present findings may partly explain insulin resistance in the severely diabetic state and the pathogenesis of the absence of ketosis in hyperglycemic hyperosmolar conditions. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Nagoya University School of Medicine | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| ID登録 | ||||||
| ID登録 | 10.18999/nagjms.51.1-4.17 | |||||
| ID登録タイプ | JaLC | |||||
| 関連情報 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/5114/5114.html | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0027-7622 | |||||
| ISSN（Online） | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2186-3326 | |||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 51, 号 1-4, p. 17-23, 発行日 1989-03 |
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| 著者版フラグ | ||||||
| 値 | publisher | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/17507 | |||||
| 識別子タイプ | HDL | |||||
