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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 51(1-4)

Natural Killer Cells in Inflammatory Lesions and Transplanted Tumors in Mouse Skin

https://doi.org/10.18999/nagjms.51.1-4.25
https://doi.org/10.18999/nagjms.51.1-4.25
e6ee7f6a-c740-4344-a9f5-1d58e9444a53
名前 / ファイル ライセンス アクション
v51n14p25_34.pdf v51n14p25_34.pdf (1.1 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-02-13
タイトル
タイトル Natural Killer Cells in Inflammatory Lesions and Transplanted Tumors in Mouse Skin
著者 NAHAR, LUTFUN

× NAHAR, LUTFUN

WEKO 47230

NAHAR, LUTFUN

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KONDO, TAKAO

× KONDO, TAKAO

WEKO 47231

KONDO, TAKAO

Search repository
HABU, SONOKO

× HABU, SONOKO

WEKO 47232

HABU, SONOKO

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OHASHI, MASARU

× OHASHI, MASARU

WEKO 47233

OHASHI, MASARU

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NAKANE, PAUL K.

× NAKANE, PAUL K.

WEKO 47234

NAKANE, PAUL K.

Search repository
キーワード
主題Scheme Other
主題 NK CELLS
キーワード
主題Scheme Other
主題 MOUSE SKIN
キーワード
主題Scheme Other
主題 IMMUNOHISTOCHEMISTRY
抄録
内容記述 The mode of natural killer (NK) cell migration to the sites of inflammation and transplanted tumors was investigated by using dry ice for physical irritation and 1-fluoro-2,4 dinitrobenzene (DNFB) for chemical irritation in mouse ear. In experiments with transplanted tumors, NK cell sensitive tumor cells (RL♂I) and insensitive tumor cells (p815) were transplanted into the ears of C3H and BALB/c mice, respectively. Employing a polyclonal rabbit antiserum against asialoGM1 (GA1), and a monoclonal rat antiserum against Thy-1 in an immunohistochemical double-staining technique, we enumerated the number of Thy-1-positive and asialoGM1- positive (Thy-1^+GA1^+) cells and Thy-1-negative and asialoGM1-positive (Thy-1^-GA1^+) cells at various times of irritation. Following physical irritation, Thy-1^-GA1^+ cells (108.8 ± 4.5/mm2 at 24 hand 71.2 ± 3.8/mm2 at 48 h) were found in the epidermis, whereas Thy-1^+GA1^+ cells were not found. In delayed-type skin reaciton by DNFB, Thy-1^-GA1^+ cells (87.1 ± 5.8/mm2 at 24h and 60.7 ± 2.9/mm2 at 48h) and Thy-1^+GA1^+ cells (26.4 ± 3.6/mm2 at 24h and 15.3 ± 4.3/mm2 at 48h) were found in the dermis. Since it was reported by previous investigators that Thy-1^+GA1^+ cells are NK cells, we assumed that NK cells infiltrated nonspecifically in the dermis in delayed-type skin reaction by DNFB. In the tumor transplant experiments. the GA1^+ cells were found near both types of tumors, but they were in contact with RL♂1 and not with p815. Because it was reported that GA1^+ monocytes do not have cytotoxicity against tumor cells, our findings suggest that GA1^+ cells migrate nonspecifically to the sites of inflammation, and that the NK cells among them may make direct contact with the tumor cells when they encounter NK cell sensitive tumors.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.51.1-4.25
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 51, 号 1-4, p. 25-34, 発行日 1989-03
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/5114/5114.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/17508
識別子タイプ HDL
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