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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 31(2)

A Study on the Effect of Hyperbaric Oxygenation on Yoshida Sarcoma : Especially on Its Influence on the Generation Time

https://doi.org/10.18999/nagjms.31.2.243
https://doi.org/10.18999/nagjms.31.2.243
964a0100-b1f0-44f0-9238-cf0a7176d074
名前 / ファイル ライセンス アクション
v31n2p243_276.pdf v31n2p243_276.pdf (4.1 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-09-26
タイトル
タイトル A Study on the Effect of Hyperbaric Oxygenation on Yoshida Sarcoma : Especially on Its Influence on the Generation Time
著者 OSADA, TAKUJI

× OSADA, TAKUJI

WEKO 96222

OSADA, TAKUJI

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抄録
内容記述 In order to observe the effect of hyperbaric oxygenation (ORP) on malignant tumors, the generation time of the Yoshida sarcoma cells was measured under various in vivo conditions. The sarcoma cells transplanted in Donryu rats were divided into 9 groups, which were accordingly exposed to OHPx1, OHPx3, NMO (1 mg/kg)x1, NMO+OHPx1, NMO+OHPx3, MMC (0.5 mg/kg)x1, MMC+OHP x1, and MMC+OHPx3, leaving a group as the control. They were served for the observation of frequency of labeled metaphases, the grain count, and mitotic index of the cells using autoradiography. In the groups of 1 and 3 times of ORP treatment, there were observed the suppression of mitosis, and the prolongation of generation time especially of S phase, due to impaired DNA synthesis. The combination of NMO and OHP rendered more intense suppression of mitosis and more marked prolongation of the generation time than did the NMO treatment alone. By combined treatment of MMC and OHP, the suppression of mitosis and the impairment of DNA synthesis were more marked than by MMC treatment alone. These results suggested the effectiveness of 0HP as an adjuvant to chemotherapy.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.31.2.243
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/312/312.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 31, 号 2, p. 243-276, 発行日 1968-09
著者版フラグ
値 publisher
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