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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 32(1)

Studies on Lipogenesis in Hereditary Obese-Hyperglycemic Mice (KK Strain)

https://doi.org/10.18999/nagjms.32.1.129
https://doi.org/10.18999/nagjms.32.1.129
d3ca19e9-836e-4728-be0c-82bf2e6ee63d
名前 / ファイル ライセンス アクション
v32n1p129_141.pdf v32n1p129_141.pdf (1.8 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-10-04
タイトル
タイトル Studies on Lipogenesis in Hereditary Obese-Hyperglycemic Mice (KK Strain)
著者 KATO, KANEFUSA

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WEKO 96834

KATO, KANEFUSA

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抄録
内容記述 Fatty acid synthesis in KK mouse, which exhibits a hereditary obese-hyperglycemic syndrome, was studied. Incorporation of [U-14C] glucose into liver fatty acid in vivo was more than four times higher in KK compared with control mice (CF1), but no significantly increased incorporation was observed into carcass fatty acid. Incorporation of [1-14C] acetate into liver fatty acid in vivo was also elevated (5 fold) in KK mice. Fatty acid synthesis from acetate by liver slices of KK mice was about three times higher than that of control. However, the con- version of acetate into fatty acid in adipose tissues from KK mice in vitro was lower than that of control. Level of Liver acetyl CoA carboxylase was twice as high in KK, but with the activity of liver citrate-cleavage enzyme, no difference was observed between KK and control mouse. Mechanisms of hyperlipogenesis in the liver of KK mouse were discussed in relation to hyperinsulinemia and hyperglycemia.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.32.1.129
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/321/321.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 32, 号 1, p. 129-141, 発行日 1969-07
著者版フラグ
値 publisher
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