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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 34(2)

Experimental Study on Sodium and Potassium Concentration Gradient and Na-K Dependent Adenosine Triphosphatase Activity in the Kidney : Part II. On Na-K Dependent Adenosine Triphosphatase Activity in the Kidney Undergoing Diuresis and Antidiuresis

https://doi.org/10.18999/nagjms.34.2.163
https://doi.org/10.18999/nagjms.34.2.163
add47736-5348-4195-88ea-7884d4fba9d0
名前 / ファイル ライセンス アクション
v34n2p163_182.pdf v34n2p163_182.pdf (2.3 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-10-10
タイトル
タイトル Experimental Study on Sodium and Potassium Concentration Gradient and Na-K Dependent Adenosine Triphosphatase Activity in the Kidney : Part II. On Na-K Dependent Adenosine Triphosphatase Activity in the Kidney Undergoing Diuresis and Antidiuresis
著者 NAKAMURA, SHINYA

× NAKAMURA, SHINYA

WEKO 98604

NAKAMURA, SHINYA

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抄録
内容記述 In Part I the concentrations of sodium and potassium were examined under the same conditions of diuresis and antidiuresis. In the present paper Na-K ATPase activity was assayed under these conditions in order to evaluate the transport of sodium and potassium by the renal tubules. Both furosemide and ethacrynic acid decreased Na-K ATPase activity in the whole homogenates of the cortex, medulla and papilla, in the cortical mitochondrial and microsomal fractions, by intravenous administration. This finding indicates that these agents produce marked diuresis by inhibiting Na·K ATPase activity. With respect to osmotic diuresis both 5% and 20% mannitol also decreased Na·K ATPase activity in all of the parts. On the other hand, both 5% and 50% glucose did not affect Na-K ATPase activity. Judging from these results, it would be sure that mannitol produces diuresis by inhibiting· Na-K ATPase and has a different mode of action on diuresis from that of glucose. With respect to antidiuresis, a low dose of vasopressin (0.1 U/kg) did not affect Na-K A TPase activity, but a high dose of vasopressin (10 U/ kg) decreased it in the whole homogenates of cortex, medulla and papilla, in the cortical mitochondrial and microsomal fractions. This decrease would be partly dependent upon the renal blood flow. It was reported in Part I that the sodium and potassium contents were increased, but Na-K ATPase activity was decreased in this work. This result would show that Na-K ATPase is independent of the reabsorption of sodium and potassium caused by administration of vasopressin. It would also be supposed that the energy required for reabsorption of sodium would be supplied at least in part by a pathway other than of ATP.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.34.2.163
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/342/342.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 34, 号 2, p. 163-182, 発行日 1971-09
著者版フラグ
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