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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 34(3)

Studies on Structure and Function of the Biological Membrane Systems : III. The Modes of Action of Corticosterones on The Isolated Subcellular Membranes

https://doi.org/10.18999/nagjms.34.3.241
https://doi.org/10.18999/nagjms.34.3.241
d3ad329e-5494-4d68-8b1f-1fd3e0ccd265
名前 / ファイル ライセンス アクション
v34n3p241_258.pdf v34n3p241_258.pdf (5.4 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2013-10-10
タイトル
タイトル Studies on Structure and Function of the Biological Membrane Systems : III. The Modes of Action of Corticosterones on The Isolated Subcellular Membranes
著者 ITATSU, YOSHIAKI

× ITATSU, YOSHIAKI

WEKO 49580

ITATSU, YOSHIAKI

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抄録
内容記述 The modes of action of corticosterones on the isolated subcellular compartments of mitochondria, lysosomes and red cell ghosts were studied by using chiefly hydrocortisone and 11-desoxycorticosterone (11-DOC) at higher concentrations than physiological ones (below 10^-6 M). The changes of those biological membrane systems were examined both electron-microscopically and biochemically. The ultrastructural alterations of the membrane structures corresponded to the changes of the enzyme activities in both radical and ion reactions which were directed or controlled in the subcellular membranes. 10^-4-10^-3 M 11-DOC induced the following changes; (a) respiratory inhibition and uncoupling of oxidative phosphorylation in mitochondria, (b) configurational changes in mitochondrial inner membrane to orthodox type involving swelling of mitochondria, (c) release of acid hydrolytic :enzymes and fragmentation of lysosomal membranes, (d) inhibition of activities of Na^+, K^+-dependent or Mg^2+-activated ATPase, (e) dislocation and micelles formation of lipid in the membrane and electron dense body formation on the surface of the membrane, (f) fusion and aggregation of membrnes. Hydrocortisone or cholesterol showed similar effects, to less degrees, as a result of non specific actions at high concentrations (10^-3 M), but hydrocortisone had a tendency to stabilize the lysosomal membranes. The different mode of action of 11-DOC and hydrocortisone on the membrane may induce the different changes of the high ordered structures in the membraneous polymers which are composed of proteins and lipids.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.34.3.241
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 34, 号 3, p. 241-258, 発行日 1972-02
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/343/343.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/18697
識別子タイプ HDL
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