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Addition of more than 30 mg% tolbutamide apparently increased the state 4 respiration rate and decreased RCI, whereas, 80 mg% tolbutamide decreased markedly the state 3 respiration rate than that of control. State 4 respiration rate was accelerated by adding 100 mg% (3.8 mM) tolbutamide, while state 3 respiration rate was decreased and P/ 0 ratio was reduced to zero showing complete uncoupling. 3. Uncoupling of oxidative phosphorylation by 100 mg% tolbutamide was similar to that of DNP, i.e., sensitive to the addition of rutamyin, 100 mg% tolbutamide can induce ATPase activity of intact rat liver mitochondria, and induced A TPase activity was reduced to zero by the addition of rutamyin just like DNP. Therefore, uncoupling site by tolbutamide may be close to the DNP sensitive site.", "subitem_description_type": "Abstract"}]}, "item_9_identifier_registration": {"attribute_name": "ID\u767b\u9332", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/nagjms.35.2-4.69", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Nagoya University School of Medicine"}]}, "item_9_relation_43": {"attribute_name": "\u7570\u7248\u3067\u3042\u308b", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/3524/3524.html", "subitem_relation_type_select": "URI"}}]}, "item_9_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_9_source_id_61": {"attribute_name": "ISSN\uff08Online\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "2186-3326", "subitem_source_identifier_type": "ISSN"}]}, "item_9_source_id_7": {"attribute_name": "ISSN\uff08print\uff09", "attribute_value_mlt": [{"subitem_source_identifier": "0027-7622", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "KATSUMATA, KAZUO"}], "nameIdentifiers": [{"nameIdentifier": "98636", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "HAGIHARA, MASAKO"}], "nameIdentifiers": [{"nameIdentifier": "98637", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "v35n24p69_77.pdf", "filesize": [{"value": "1.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1100000.0, "url": {"label": "v35n24p69_77.pdf", "url": "https://nagoya.repo.nii.ac.jp/record/16703/files/v35n24p69_77.pdf"}, "version_id": "6c8331aa-8763-4179-a837-11a19c30e5cb"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Uncoupling Effect of Tolbutamide on Oxidative Phosphorylation of Liver Mitochondria", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Uncoupling Effect of Tolbutamide on Oxidative Phosphorylation of Liver Mitochondria"}]}, "item_type_id": "9", "owner": "1", "path": ["499/508/509/1528"], "permalink_uri": "https://doi.org/10.18999/nagjms.35.2-4.69", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2013-10-17"}, "publish_date": "2013-10-17", "publish_status": "0", "recid": "16703", "relation": {}, "relation_version_is_last": true, "title": ["Uncoupling Effect of Tolbutamide on Oxidative Phosphorylation of Liver Mitochondria"], "weko_shared_id": null}