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Uncoupling Effect of Tolbutamide on Oxidative Phosphorylation of Liver Mitochondria
https://doi.org/10.18999/nagjms.35.2-4.69
https://doi.org/10.18999/nagjms.35.2-4.697e428a42-1207-41fb-ab08-670651ea75b9
名前 / ファイル | ライセンス | アクション |
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v35n24p69_77.pdf (1.1 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2013-10-17 | |||||
タイトル | ||||||
タイトル | Uncoupling Effect of Tolbutamide on Oxidative Phosphorylation of Liver Mitochondria | |||||
言語 | en | |||||
著者 |
KATSUMATA, KAZUO
× KATSUMATA, KAZUO× HAGIHARA, MASAKO |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
抄録 | ||||||
内容記述 | 1. The effect of tolbutamide on the oxidation rate, respiratory control index and P/0 ratio of intact rat liver mitochondria was studied. 2. Addition of more than 30 mg% tolbutamide apparently increased the state 4 respiration rate and decreased RCI, whereas, 80 mg% tolbutamide decreased markedly the state 3 respiration rate than that of control. State 4 respiration rate was accelerated by adding 100 mg% (3.8 mM) tolbutamide, while state 3 respiration rate was decreased and P/ 0 ratio was reduced to zero showing complete uncoupling. 3. Uncoupling of oxidative phosphorylation by 100 mg% tolbutamide was similar to that of DNP, i.e., sensitive to the addition of rutamyin, 100 mg% tolbutamide can induce ATPase activity of intact rat liver mitochondria, and induced A TPase activity was reduced to zero by the addition of rutamyin just like DNP. Therefore, uncoupling site by tolbutamide may be close to the DNP sensitive site. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Nagoya University School of Medicine | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.35.2-4.69 | |||||
ID登録タイプ | JaLC | |||||
関連情報 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | URI | |||||
関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/3524/3524.html | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0027-7622 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 2186-3326 | |||||
書誌情報 |
en : Nagoya Journal of Medical Science 巻 35, 号 2-4, p. 69-77, 発行日 1973-03 |
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著者版フラグ | ||||||
値 | publisher |