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Impact of Low Levels of Vascular Endothelial Growth Factor After Myocardial Infarction on 6-Month Clinical Outcome : Results From the Nagoya Acute Myocardial Infarction Study
http://hdl.handle.net/2237/18822
http://hdl.handle.net/2237/1882228e16360-7978-4588-ac6e-06bd7e522010
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k9988.pdf (626.2 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||||
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公開日 | 2013-11-06 | |||||||
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タイトル | Impact of Low Levels of Vascular Endothelial Growth Factor After Myocardial Infarction on 6-Month Clinical Outcome : Results From the Nagoya Acute Myocardial Infarction Study | |||||||
言語 | en | |||||||
著者 |
Matsudaira, Kyoko
× Matsudaira, Kyoko× Maeda, Kengo× Okumura, Naoki× Yoshikawa, Daiji× Morita, Yasuhiro× Mitsuhashi, Hirotsugu× Ishii, Hideki× Kondo, Takahisa× Murohara, Toyoaki× on, behalf of the Nagoya Acute Myocardial Infarction Study (NAMIS) Group
WEKO
49859
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アクセス権 | ||||||||
アクセス権 | open access | |||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
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内容記述 | Background: Vascular endothelial growth factor (VEGF) is induced by myocardial ischemia and is thought to facilitate cardiovascular repair after acute myocardial infarction (AMI). However, the association between the plasma VEGF levels and clinical outcome in AMI patients is unclear. Methods and Results: We evaluated 879 AMI patients undergoing successful primary revascularization within 24h of symptom onset. The patients were classified into 3 groups according to tertiles of plasma VEGF levels at 7 days after the onset of AMI. Major adverse cardiovascular and cerebrovascular events (MACCE), defined as cardiac death, recurrent acute coronary syndrome, hospital readmission for heart failure, or stroke, were assessed during the 6-month follow-up period. The incidence of MACCE was the least frequent in the middle tertile. Compared to the middle tertile, patients in the low tertile were at a significantly higher risk for MACCE even after adjusting for baseline characteristics (hazard ratio [HR] 2.67, 95% confidence interval [CI] 1.18-6.06, P=0.019). An absence of statin treatment before onset and a younger age (HR 0.54, 0.87; 95%CI 0.33-0.90, 0.76-0.99; P=0.017, 0.037; respectively) were significantly associated with low VEGF. Conclusions: Low plasma VEGF levels at 7 days after the onset of AMI were associated with a significantly increased risk for MACCE during 6 months of follow-up. | |||||||
言語 | en | |||||||
内容記述タイプ | Abstract | |||||||
内容記述 | ||||||||
内容記述 | 名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成25年3月25日 松平京子氏の博士論文として提出された | |||||||
言語 | ja | |||||||
内容記述タイプ | Other | |||||||
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言語 | en | |||||||
出版者 | THE JAPANESE CIRCULATION SOCIETY | |||||||
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言語 | eng | |||||||
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資源 | http://purl.org/coar/resource_type/c_db06 | |||||||
タイプ | doctoral thesis | |||||||
DOI | ||||||||
関連タイプ | isVersionOf | |||||||
識別子タイプ | DOI | |||||||
関連識別子 | https://doi.org/10.1253/circj.CJ-11-1127 | |||||||
ISSN | ||||||||
収録物識別子タイプ | PISSN | |||||||
収録物識別子 | 1346-9843 | |||||||
書誌情報 |
en : Circulation Journal 巻 76, 号 6, p. 1509-1516, 発行日 2012-03-27 |
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学位名 | ||||||||
言語 | ja | |||||||
学位名 | 博士(医学) | |||||||
学位授与機関 | ||||||||
学位授与機関識別子Scheme | kakenhi | |||||||
学位授与機関識別子 | 13901 | |||||||
言語 | ja | |||||||
学位授与機関名 | 名古屋大学 | |||||||
言語 | en | |||||||
学位授与機関名 | Nagoya University | |||||||
学位授与年度 | ||||||||
学位授与年度 | 2011 | |||||||
学位授与年月日 | ||||||||
学位授与年月日 | 2012-03-27 | |||||||
学位授与番号 | ||||||||
学位授与番号 | 甲第9988号 | |||||||
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値 | publisher | |||||||
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識別子 | http://dx.doi.org/10.1253/circj.CJ-11-1127 | |||||||
識別子タイプ | DOI | |||||||
URI | ||||||||
識別子 | http://hdl.handle.net/2237/18822 | |||||||
識別子タイプ | HDL |