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  1. C100 医学部/医学系研究科
  2. C100d 学位論文
  3. 博士論文(医博・論医博)

Impact of Low Levels of Vascular Endothelial Growth Factor After Myocardial Infarction on 6-Month Clinical Outcome : Results From the Nagoya Acute Myocardial Infarction Study

http://hdl.handle.net/2237/18822
28e16360-7978-4588-ac6e-06bd7e522010
名前 / ファイル ライセンス アクション
k9988.pdf k9988.pdf (626.2 kB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2013-11-06
タイトル
タイトル Impact of Low Levels of Vascular Endothelial Growth Factor After Myocardial Infarction on 6-Month Clinical Outcome : Results From the Nagoya Acute Myocardial Infarction Study
著者 Matsudaira, Kyoko

× Matsudaira, Kyoko

WEKO 49850

Matsudaira, Kyoko

Search repository
Maeda, Kengo

× Maeda, Kengo

WEKO 49851

Maeda, Kengo

Search repository
Okumura, Naoki

× Okumura, Naoki

WEKO 49852

Okumura, Naoki

Search repository
Yoshikawa, Daiji

× Yoshikawa, Daiji

WEKO 49853

Yoshikawa, Daiji

Search repository
Morita, Yasuhiro

× Morita, Yasuhiro

WEKO 49854

Morita, Yasuhiro

Search repository
Mitsuhashi, Hirotsugu

× Mitsuhashi, Hirotsugu

WEKO 49855

Mitsuhashi, Hirotsugu

Search repository
Ishii, Hideki

× Ishii, Hideki

WEKO 49856

Ishii, Hideki

Search repository
Kondo, Takahisa

× Kondo, Takahisa

WEKO 49857

Kondo, Takahisa

Search repository
Murohara, Toyoaki

× Murohara, Toyoaki

WEKO 49858

Murohara, Toyoaki

Search repository
on, behalf of the Nagoya Acute Myocardial Infarction Study (NAMIS) Group

× on, behalf of the Nagoya Acute Myocardial Infarction Study (NAMIS) Group

WEKO 49859

on, behalf of the Nagoya Acute Myocardial Infarction Study (NAMIS) Group

Search repository
抄録
内容記述 Background: Vascular endothelial growth factor (VEGF) is induced by myocardial ischemia and is thought to facilitate cardiovascular repair after acute myocardial infarction (AMI). However, the association between the plasma VEGF levels and clinical outcome in AMI patients is unclear. Methods and Results: We evaluated 879 AMI patients undergoing successful primary revascularization within 24h of symptom onset. The patients were classified into 3 groups according to tertiles of plasma VEGF levels at 7 days after the onset of AMI. Major adverse cardiovascular and cerebrovascular events (MACCE), defined as cardiac death, recurrent acute coronary syndrome, hospital readmission for heart failure, or stroke, were assessed during the 6-month follow-up period. The incidence of MACCE was the least frequent in the middle tertile. Compared to the middle tertile, patients in the low tertile were at a significantly higher risk for MACCE even after adjusting for baseline characteristics (hazard ratio [HR] 2.67, 95% confidence interval [CI] 1.18-6.06, P=0.019). An absence of statin treatment before onset and a younger age (HR 0.54, 0.87; 95%CI 0.33-0.90, 0.76-0.99; P=0.017, 0.037; respectively) were significantly associated with low VEGF. Conclusions: Low plasma VEGF levels at 7 days after the onset of AMI were associated with a significantly increased risk for MACCE during 6 months of follow-up.
内容記述タイプ Abstract
内容記述
内容記述 名古屋大学博士学位論文 学位の種類 : 博士(医学)(課程) 学位授与年月日:平成25年3月25日 松平京子氏の博士論文として提出された
内容記述タイプ Other
出版者
出版者 THE JAPANESE CIRCULATION SOCIETY
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_46ec
タイプ thesis
ISSN
収録物識別子タイプ ISSN
収録物識別子 1346-9843
書誌情報 Circulation Journal

巻 76, 号 6, p. 1509-1516, 発行日 2012-03-27
学位名
学位名 博士(医学)
学位授与機関
学位授与機関名
学位授与機関名 名古屋大学
学位授与年度
学位授与年度 2011
学位授与年月日
学位授与年月日 2012-03-27
学位授与番号
学位授与番号 13901甲第9988号
著者版フラグ
値 publisher
URI
識別子 http://dx.doi.org/10.1253/circj.CJ-11-1127
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/18822
識別子タイプ HDL
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