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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 76(1-2)

Premature Cardiac Senescence in DahlS.Z-Lepr fa/Lepr fa Rats as a New Animal Model of Metabolic Syndrome

https://doi.org/10.18999/nagjms.76.1-2.35
https://doi.org/10.18999/nagjms.76.1-2.35
3a2ac68f-2001-413c-a875-fd177b480659
名前 / ファイル ライセンス アクション
05_Takahashi.pdf 05_Takahashi.pdf (570.8 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2014-03-03
タイトル
タイトル Premature Cardiac Senescence in DahlS.Z-Lepr fa/Lepr fa Rats as a New Animal Model of Metabolic Syndrome
著者 TAKAHASHI, KEIJI

× TAKAHASHI, KEIJI

WEKO 51109

TAKAHASHI, KEIJI

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TAKATSU, MIWA

× TAKATSU, MIWA

WEKO 51110

TAKATSU, MIWA

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HATTORI, TAKUYA

× HATTORI, TAKUYA

WEKO 51111

HATTORI, TAKUYA

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MURASE, TAMAYO

× MURASE, TAMAYO

WEKO 51112

MURASE, TAMAYO

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OHURA, SAE

× OHURA, SAE

WEKO 51113

OHURA, SAE

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TAKESHITA, YUURI

× TAKESHITA, YUURI

WEKO 51114

TAKESHITA, YUURI

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WATANABE, SHOGO

× WATANABE, SHOGO

WEKO 51115

WATANABE, SHOGO

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MUROHARA, TOYOAKI

× MUROHARA, TOYOAKI

WEKO 51116

MUROHARA, TOYOAKI

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NAGATA, KOHZO

× NAGATA, KOHZO

WEKO 51117

NAGATA, KOHZO

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キーワード
主題Scheme Other
主題 metabolic syndrome
キーワード
主題Scheme Other
主題 cardiac remodeling
キーワード
主題Scheme Other
主題 oxidative stress
キーワード
主題Scheme Other
主題 renin-angiotensin-aldosterone system
キーワード
主題Scheme Other
主題 cardiac senescence
抄録
内容記述 Aging is accelerated by metabolic and cardiovascular diseases, and the risk of these diseases increases with age. Obesity is an important risk factor for many age-related diseases and is linked to reduced telomere length in white blood cells. We investigated whether cardiac senescence might be enhanced in DahlS.ZLepr fa/Lepr fa (DS/obese) rats, which we recently established as a new animal model of metabolic syndrome. The heart of DS/obese rats was compared with that of homozygous lean littermates (DahlS.Z-Lepr+/Lepr+, or DS/lean, rats). DS/obese rats manifested hypertension as well as left ventricular hypertrophy, fibrosis, and diastolic dysfunction at 18 weeks of age. Myocardial oxidative stress and inflammation were increased in DS/obese rats compared with DS/lean rats. Telomere length in myocardial cells did not differ between the two rat strains, whereas telomerase activity and expression of the telomerase reverse transcriptase gene were increased in DS/obese rats. Expression of the senescence-associated genes for checkpoint kinase 2 (Chk2), p53, and p21 as well as that of genes related to the renin-angiotensin-aldosterone system were also up-regulated in the DS/obese rat heart. Our results indicate that DS/obese rats undergo premature cardiac senescence as well as cardiac remodeling in association with the development of diastolic dysfunction in these animals.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.76.1-2.35
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 76, 号 1-2, p. 35-49, 発行日 2014-02
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7612/7612.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/19482
識別子タイプ HDL
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