ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

  1. C100 医学部/医学系研究科
  2. C100b 刊行物
  3. Nagoya journal of medical science
  4. 76(1-2)

Premature Cardiac Senescence in DahlS.Z-Lepr fa/Lepr fa Rats as a New Animal Model of Metabolic Syndrome

https://doi.org/10.18999/nagjms.76.1-2.35
https://doi.org/10.18999/nagjms.76.1-2.35
3a2ac68f-2001-413c-a875-fd177b480659
名前 / ファイル ライセンス アクション
05_Takahashi.pdf 05_Takahashi.pdf (570.8 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2014-03-03
タイトル
タイトル Premature Cardiac Senescence in DahlS.Z-Lepr fa/Lepr fa Rats as a New Animal Model of Metabolic Syndrome
言語 en
著者 TAKAHASHI, KEIJI

× TAKAHASHI, KEIJI

WEKO 51109

en TAKAHASHI, KEIJI

Search repository
TAKATSU, MIWA

× TAKATSU, MIWA

WEKO 51110

en TAKATSU, MIWA

Search repository
HATTORI, TAKUYA

× HATTORI, TAKUYA

WEKO 51111

en HATTORI, TAKUYA

Search repository
MURASE, TAMAYO

× MURASE, TAMAYO

WEKO 51112

en MURASE, TAMAYO

Search repository
OHURA, SAE

× OHURA, SAE

WEKO 51113

en OHURA, SAE

Search repository
TAKESHITA, YUURI

× TAKESHITA, YUURI

WEKO 51114

en TAKESHITA, YUURI

Search repository
WATANABE, SHOGO

× WATANABE, SHOGO

WEKO 51115

en WATANABE, SHOGO

Search repository
MUROHARA, TOYOAKI

× MUROHARA, TOYOAKI

WEKO 51116

en MUROHARA, TOYOAKI

Search repository
NAGATA, KOHZO

× NAGATA, KOHZO

WEKO 51117

en NAGATA, KOHZO

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 metabolic syndrome
キーワード
主題Scheme Other
主題 cardiac remodeling
キーワード
主題Scheme Other
主題 oxidative stress
キーワード
主題Scheme Other
主題 renin-angiotensin-aldosterone system
キーワード
主題Scheme Other
主題 cardiac senescence
抄録
内容記述タイプ Abstract
内容記述 Aging is accelerated by metabolic and cardiovascular diseases, and the risk of these diseases increases with age. Obesity is an important risk factor for many age-related diseases and is linked to reduced telomere length in white blood cells. We investigated whether cardiac senescence might be enhanced in DahlS.ZLepr fa/Lepr fa (DS/obese) rats, which we recently established as a new animal model of metabolic syndrome. The heart of DS/obese rats was compared with that of homozygous lean littermates (DahlS.Z-Lepr+/Lepr+, or DS/lean, rats). DS/obese rats manifested hypertension as well as left ventricular hypertrophy, fibrosis, and diastolic dysfunction at 18 weeks of age. Myocardial oxidative stress and inflammation were increased in DS/obese rats compared with DS/lean rats. Telomere length in myocardial cells did not differ between the two rat strains, whereas telomerase activity and expression of the telomerase reverse transcriptase gene were increased in DS/obese rats. Expression of the senescence-associated genes for checkpoint kinase 2 (Chk2), p53, and p21 as well as that of genes related to the renin-angiotensin-aldosterone system were also up-regulated in the DS/obese rat heart. Our results indicate that DS/obese rats undergo premature cardiac senescence as well as cardiac remodeling in association with the development of diastolic dysfunction in these animals.
言語 en
出版者
出版者 Nagoya University School of Medicine
言語 en
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/nagjms.76.1-2.35
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7612/7612.html
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ EISSN
収録物識別子 2186-3326
書誌情報 en : Nagoya Journal of Medical Science

巻 76, 号 1-2, p. 35-49, 発行日 2014-02
著者版フラグ
値 publisher
URI
識別子 http://hdl.handle.net/2237/19482
識別子タイプ HDL
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 11:24:26.794358
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR 2.0
  • OAI-PMH JPCOAR 1.0
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3