{"_buckets": {"deposit": "3a442818-9adb-434c-97c9-82341ba6ed67"}, "_deposit": {"id": "17399", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "17399"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00017399", "sets": ["1563"]}, "item_9_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2014-02", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1-2", "bibliographicPageEnd": "49", "bibliographicPageStart": "35", "bibliographicVolumeNumber": "76", "bibliographic_titles": [{"bibliographic_title": "Nagoya Journal of Medical Science"}]}]}, "item_9_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Aging is accelerated by metabolic and cardiovascular diseases, and the risk of these diseases increases with age. Obesity is an important risk factor for many age-related diseases and is linked to reduced telomere length in white blood cells. We investigated whether cardiac senescence might be enhanced in DahlS.ZLepr fa/Lepr fa (DS/obese) rats, which we recently established as a new animal model of metabolic syndrome. The heart of DS/obese rats was compared with that of homozygous lean littermates (DahlS.Z-Lepr+/Lepr+, or DS/lean, rats). DS/obese rats manifested hypertension as well as left ventricular hypertrophy, fibrosis, and diastolic dysfunction at 18 weeks of age. Myocardial oxidative stress and inflammation were increased in DS/obese rats compared with DS/lean rats. Telomere length in myocardial cells did not differ between the two rat strains, whereas telomerase activity and expression of the telomerase reverse transcriptase gene were increased in DS/obese rats. Expression of the senescence-associated genes for checkpoint kinase 2 (Chk2), p53, and p21 as well as that of genes related to the renin-angiotensin-aldosterone system were also up-regulated in the DS/obese rat heart. Our results indicate that DS/obese rats undergo premature cardiac senescence as well as cardiac remodeling in association with the development of diastolic dysfunction in these animals.", "subitem_description_type": "Abstract"}]}, "item_9_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "URI", "subitem_identifier_uri": "http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/7612/7612.html"}, {"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/19482"}]}, "item_9_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/nagjms.76.1-2.35", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Nagoya University School of Medicine"}]}, "item_9_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_9_source_id_7": {"attribute_name": "ISSN（print）", "attribute_value_mlt": [{"subitem_source_identifier": "0027-7622", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "TAKAHASHI, KEIJI"}], "nameIdentifiers": [{"nameIdentifier": "51109", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TAKATSU, MIWA"}], "nameIdentifiers": [{"nameIdentifier": "51110", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "HATTORI, TAKUYA"}], "nameIdentifiers": [{"nameIdentifier": "51111", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "MURASE, TAMAYO"}], "nameIdentifiers": [{"nameIdentifier": "51112", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "OHURA, SAE"}], "nameIdentifiers": [{"nameIdentifier": "51113", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TAKESHITA, YUURI"}], "nameIdentifiers": [{"nameIdentifier": "51114", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "WATANABE, SHOGO"}], "nameIdentifiers": [{"nameIdentifier": "51115", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "MUROHARA, TOYOAKI"}], "nameIdentifiers": [{"nameIdentifier": "51116", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "NAGATA, KOHZO"}], "nameIdentifiers": [{"nameIdentifier": "51117", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-21"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "05_Takahashi.pdf", "filesize": [{"value": "570.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 570800.0, "url": {"label": "05_Takahashi.pdf", "url": "https://nagoya.repo.nii.ac.jp/record/17399/files/05_Takahashi.pdf"}, "version_id": "47a01742-e883-4eb2-8509-c73e63fe538b"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "metabolic syndrome", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cardiac remodeling", "subitem_subject_scheme": "Other"}, {"subitem_subject": "oxidative stress", "subitem_subject_scheme": "Other"}, {"subitem_subject": "renin-angiotensin-aldosterone system", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cardiac senescence", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Premature Cardiac Senescence in DahlS.Z-Lepr fa/Lepr fa Rats as a New Animal Model of Metabolic Syndrome", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Premature Cardiac Senescence in DahlS.Z-Lepr fa/Lepr fa Rats as a New Animal Model of Metabolic Syndrome"}]}, "item_type_id": "9", "owner": "1", "path": ["1563"], "permalink_uri": "https://doi.org/10.18999/nagjms.76.1-2.35", "pubdate": {"attribute_name": "公開日", "attribute_value": "2014-03-03"}, "publish_date": "2014-03-03", "publish_status": "0", "recid": "17399", "relation": {}, "relation_version_is_last": true, "title": ["Premature Cardiac Senescence in DahlS.Z-Lepr fa/Lepr fa Rats as a New Animal Model of Metabolic Syndrome"], "weko_shared_id": 3}