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  1. B300 農学部/生命農学研究科
  2. B300a 雑誌掲載論文
  3. 学術雑誌

Mapping an Overdominant Quantitative Trait Locus for Heterosis of Body Weight in Mice

http://hdl.handle.net/2237/20573
b7d71221-6d89-4818-8c74-1ce25370ec45
名前 / ファイル ライセンス アクション
Heterosis_J-Hered_Revised2.pdf Heterosis_J-Hered_Revised2.pdf (344.1 kB)
Ishikawa-Fig1.pdf Ishikawa-Fig1.pdf (30.2 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-09-26
タイトル
タイトル Mapping an Overdominant Quantitative Trait Locus for Heterosis of Body Weight in Mice
著者 Ishikawa, Akira

× Ishikawa, Akira

WEKO 53670

Ishikawa, Akira

Search repository
権利
権利情報 This is a pre-copyedited, author-produced PDF of an article accepted for publication in [Journal of Heredity] following peer review. The version of record [Journal of Heredity. v.100, n.4, 2009, p.501-504] is available online at: http://dx.doi.org/10.1093/jhered/esp004.
キーワード
主題Scheme Other
主題 body weight
キーワード
主題Scheme Other
主題 heterosis
キーワード
主題Scheme Other
主題 mice
キーワード
主題Scheme Other
主題 overdominance
キーワード
主題Scheme Other
主題 QTL
抄録
内容記述 The genetic basis of heterosis has not been elucidated. Previously, a congenic mouse strain with a 44-Mb genomic region of proximal chromosome 2 containing the allele derived from wild Mus musculus castaneus at Pbwg1, a quantitative trait locus (QTL) for body weight and growth, has been developed. In this study, to fine-map and characterize body weight QTLs on the congenic region, QTL analysis of body weight at 1, 3, 6, and 10 weeks after birth was performed on a population of 265 F2 intercross mice between the developed congenic strain and its background strain C57BL/6J. A significant QTL (named Pbwg1.10) affecting body weight at 6 and 10 weeks of age was identified within an approximately 21-Mb support interval. Surprisingly, Pbwg1.10 had an overdominance effect and caused heterosis for body weight. This result supported the overdominance hypothesis explaining heterosis.
内容記述タイプ Abstract
出版者
出版者 Oxford University Press
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
ISSN
収録物識別子タイプ ISSN
収録物識別子 0022-1503
書誌情報 Journal of Heredity

巻 100, 号 4, p. 501-504, 発行日 2009-03
著者版フラグ
値 author
URI
識別子 http://dx.doi.org/10.1093/jhered/esp004
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/20573
識別子タイプ HDL
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