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Mapping an Overdominant Quantitative Trait Locus for Heterosis of Body Weight in Mice
http://hdl.handle.net/2237/20573
http://hdl.handle.net/2237/20573b7d71221-6d89-4818-8c74-1ce25370ec45
| 名前 / ファイル | ライセンス | アクション |
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Heterosis_J-Hered_Revised2.pdf (344.1 kB)
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Ishikawa-Fig1.pdf (30.2 kB)
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-09-26 | |||||
| タイトル | ||||||
| タイトル | Mapping an Overdominant Quantitative Trait Locus for Heterosis of Body Weight in Mice | |||||
| 言語 | en | |||||
| 著者 |
Ishikawa, Akira
× Ishikawa, Akira |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 権利情報 | This is a pre-copyedited, author-produced PDF of an article accepted for publication in [Journal of Heredity] following peer review. The version of record [Journal of Heredity. v.100, n.4, 2009, p.501-504] is available online at: http://dx.doi.org/10.1093/jhered/esp004. | |||||
| 言語 | en | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | body weight | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | heterosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | mice | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | overdominance | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | QTL | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The genetic basis of heterosis has not been elucidated. Previously, a congenic mouse strain with a 44-Mb genomic region of proximal chromosome 2 containing the allele derived from wild Mus musculus castaneus at Pbwg1, a quantitative trait locus (QTL) for body weight and growth, has been developed. In this study, to fine-map and characterize body weight QTLs on the congenic region, QTL analysis of body weight at 1, 3, 6, and 10 weeks after birth was performed on a population of 265 F2 intercross mice between the developed congenic strain and its background strain C57BL/6J. A significant QTL (named Pbwg1.10) affecting body weight at 6 and 10 weeks of age was identified within an approximately 21-Mb support interval. Surprisingly, Pbwg1.10 had an overdominance effect and caused heterosis for body weight. This result supported the overdominance hypothesis explaining heterosis. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Oxford University Press | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1093/jhered/esp004 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0022-1503 | |||||
| 書誌情報 |
en : Journal of Heredity 巻 100, 号 4, p. 501-504, 発行日 2009-03 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
| URI | ||||||
| 識別子 | http://dx.doi.org/10.1093/jhered/esp004 | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/20573 | |||||
| 識別子タイプ | HDL | |||||
