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  1. C100 医学部/医学系研究科
  2. C100b 刊行物
  3. Nagoya journal of medical science
  4. 83(1)

Genome-wide association study of serum prostate-specific antigen levels based on 1000 Genomes imputed data in Japanese : the Japan Multi-Institutional Collaborative Cohort Study

https://doi.org/10.18999/nagjms.83.1.183
https://doi.org/10.18999/nagjms.83.1.183
cfea5454-b9e8-4195-bba8-0e0f0bc62a1a
名前 / ファイル ライセンス アクション
17_Hishida.pdf 17_Hishida.pdf (3.6 MB)
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Item type itemtype_ver1(1)
公開日 2021-05-31
タイトル
タイトル Genome-wide association study of serum prostate-specific antigen levels based on 1000 Genomes imputed data in Japanese : the Japan Multi-Institutional Collaborative Cohort Study
言語 en
著者 Hishida, Asahi

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Nakatochi, Masahiro

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Tamura, Takashi

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Nagayoshi, Mako

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Okada, Rieko

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Kubo, Yoko

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Tsukamoto, Mineko

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Kadomatsu, Yuka

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Suzuki, Sadao

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Nishiyama, Takeshi

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Kuriyama, Nagato

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Watanabe, Isao

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Takezaki, Toshiro

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Nishimoto, Daisaku

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Kuriki, Kiyonori

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Arisawa, Kokichi

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Katsuura-Kamano, Sakurako

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Mikami, Haruo

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Kusakabe, Miho

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Oze, Isao

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N., Yuriko

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Nakamura, Yasuyuki

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Kadota, Aya

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Shimanoe, Chisato

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Tanaka, Keitaro

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Ikezaki, Hiroaki

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Murata, Masayuki

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Kubo, Michiaki

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Momozawa, Yukihide

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Takeuchi, Kenji

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Wakai, Kenji

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報Resource http://creativecommons.org/licenses/by-nc-nd/4.0/
権利情報 Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
キーワード
主題Scheme Other
主題 PSA
キーワード
主題Scheme Other
主題 GWAS
キーワード
主題Scheme Other
主題 genetic polymorphisms
キーワード
主題Scheme Other
主題 J-MICC Study
内容記述
内容記述タイプ Abstract
内容記述 Prostate cancer is emerging as a significant global public health burden. The incidence and prevalence of prostate cancer has increased in Japan, as westernized lifestyles become more popular. Recent advances in genetic epidemiology, including genome-wide association studies (GWASs), have identified considerable numbers of human genetic factors associated with diseases. Several GWASs have reported significant loci associated with serum prostate-specific antigen (PSA) levels. One GWAS, which was based on classic GWAS microarray measurements, has been reported for Japanese so far. In the present study, we conducted a GWAS of serum PSA using 1000Genomes imputed GWAS data (n =1,216) from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study, to detect candidate novel genetic loci that influence serum PSA levels in Japanese. The association of SNPs/genetic variants with serum PSA as a continuous variable was tested using the linear Wald test. SNP rs10000006 in SGMS2 (sphingomyelin synthase 2) on chromosome 4 had genome-wide significance (P <5×10−8), and eight variants on three chromosomes (chromosomes 12, 14, 15) had genome-wide suggestive levels of significance (P <1×10−6). With an independent data set from the J-MICC Shizuoka Study (n = 2,447), the association of the SGMS2SNP with blood PSA levels was not replicated. Although our GWAS failed to detect novel loci associated with serum PSA levels in the Japanese cohort, it confirmed the significant effects of previously reported genetic loci on PSA levels in Japanese. Importantly, our results confirmed the significance of KLK3 SNPs also in Japanese, implying that consideration of individual genetic information in prostate cancer diagnosis may be possible in the future.
言語 en
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語 en
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
ID登録
ID登録 10.18999/nagjms.83.1.183
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/831.html
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 0027-7622
収録物識別子
収録物識別子タイプ EISSN
収録物識別子 2186-3326
書誌情報 en : Nagoya Journal of Medical Science

巻 83, 号 1, p. 183-194, 発行日 2021-02
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