| Item type |
itemtype_ver1(1) |
| 公開日 |
2021-05-31 |
| タイトル |
|
|
タイトル |
Genome-wide association study of serum prostate-specific antigen levels based on 1000 Genomes imputed data in Japanese : the Japan Multi-Institutional Collaborative Cohort Study |
|
言語 |
en |
| 著者 |
Hishida, Asahi
Nakatochi, Masahiro
Tamura, Takashi
Nagayoshi, Mako
Okada, Rieko
Kubo, Yoko
Tsukamoto, Mineko
Kadomatsu, Yuka
Suzuki, Sadao
Nishiyama, Takeshi
Kuriyama, Nagato
Watanabe, Isao
Takezaki, Toshiro
Nishimoto, Daisaku
Kuriki, Kiyonori
Arisawa, Kokichi
Katsuura-Kamano, Sakurako
Mikami, Haruo
Kusakabe, Miho
Oze, Isao
N., Yuriko
Nakamura, Yasuyuki
Kadota, Aya
Shimanoe, Chisato
Tanaka, Keitaro
Ikezaki, Hiroaki
Murata, Masayuki
Kubo, Michiaki
Momozawa, Yukihide
Takeuchi, Kenji
Wakai, Kenji
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利 |
|
|
言語 |
en |
|
権利情報Resource |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
権利情報 |
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
PSA |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
GWAS |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
genetic polymorphisms |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
J-MICC Study |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Prostate cancer is emerging as a significant global public health burden. The incidence and prevalence of prostate cancer has increased in Japan, as westernized lifestyles become more popular. Recent advances in genetic epidemiology, including genome-wide association studies (GWASs), have identified considerable numbers of human genetic factors associated with diseases. Several GWASs have reported significant loci associated with serum prostate-specific antigen (PSA) levels. One GWAS, which was based on classic GWAS microarray measurements, has been reported for Japanese so far. In the present study, we conducted a GWAS of serum PSA using 1000Genomes imputed GWAS data (n =1,216) from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study, to detect candidate novel genetic loci that influence serum PSA levels in Japanese. The association of SNPs/genetic variants with serum PSA as a continuous variable was tested using the linear Wald test. SNP rs10000006 in SGMS2 (sphingomyelin synthase 2) on chromosome 4 had genome-wide significance (P <5×10−8), and eight variants on three chromosomes (chromosomes 12, 14, 15) had genome-wide suggestive levels of significance (P <1×10−6). With an independent data set from the J-MICC Shizuoka Study (n = 2,447), the association of the SGMS2SNP with blood PSA levels was not replicated. Although our GWAS failed to detect novel loci associated with serum PSA levels in the Japanese cohort, it confirmed the significant effects of previously reported genetic loci on PSA levels in Japanese. Importantly, our results confirmed the significance of KLK3 SNPs also in Japanese, implying that consideration of individual genetic information in prostate cancer diagnosis may be possible in the future. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Nagoya University Graduate School of Medicine, School of Medicine |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| ID登録 |
|
|
ID登録 |
10.18999/nagjms.83.1.183 |
|
ID登録タイプ |
JaLC |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/831.html |
| 収録物識別子 |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0027-7622 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2186-3326 |
| 書誌情報 |
en : Nagoya Journal of Medical Science
巻 83,
号 1,
p. 183-194,
発行日 2021-02
|
17_Hishida.pdf (3.6 MB)
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