{"_buckets": {"deposit": "b4809888-ca07-4da1-8cf9-b4b997e018ff"}, "_deposit": {"created_by": 17, "id": "2001431", "owner": "17", "owners": [17], "owners_ext": {"displayname": "\u56f3\u66f8\u60c5\u5831\u4fc2", "username": "repository"}, "pid": {"revision_id": 0, "type": "depid", "value": "2001431"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:02001431"}, "author_link": [], "item_1615768549627": {"attribute_name": "\u51fa\u7248\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_1629683748249": {"attribute_name": "\u65e5\u4ed8", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2022-03-01", "subitem_date_issued_type": "Available"}]}, "item_9_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2021-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "752", "bibliographicPageStart": "743", "bibliographicVolumeNumber": "100", "bibliographic_titles": [{"bibliographic_title": "Annals of Hematology", "bibliographic_titleLang": "en"}]}]}, "item_9_description_4": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "To overcome the delayed or failed engraftment after unrelated cord blood transplantation (CBT), we conducted a multicenter phase II study of intrabone single-unit CBT without antithymocyte globulin (ATG) for adult patients with hematological malignancies (UMIN-CTR, UMIN000020997). Sixty-four patients received an intrabone injection of unwashed (n\u2009=\u200961) or washed (n\u2009=\u20093) cord blood after local anesthesia. All injection-related adverse events were mild and resolved spontaneously. Sixty-two patients were evaluable for the efficacy of intrabone CBT of serological HLA-A, -B, and -DR \u2265\u20094/6 matched cord blood with a median number of 2.57\u2009\u00d7\u200910^7/kg cryopreserved total nucleated cells. The probability of survival with neutrophil engraftment on day 28 was 77.4% (95% confidence interval, 67.0\u201385.8%), which exceeded the threshold value. The cumulative incidences of neutrophils \u2265\u20090.5\u2009\u00d7\u200910^9/L on day 60 was 80.6% (68.2\u201388.6%), with a median time to recovery of 21 days after transplantation. The cumulative incidences of platelets \u2265\u200920\u2009\u00d7\u200910^9/L and platelets \u2265\u200950\u2009\u00d7\u200910^9/L on day 100 were 75.8% (62.6\u201384.9%) and 72.6% (59.4\u201382.1%), respectively, with median time to platelets \u2265\u200920\u2009\u00d7\u200910^9/L and platelets \u2265\u200950\u2009\u00d7\u200910^9/L of 38 and 45 days after transplantation, respectively. The cumulative incidences of grade II\u2013IV and III\u2013IV acute graft-versus-host disease were 29.0% and 6.5%, respectively. All responded to steroid therapy, and secondary treatments were not required. The present study suggests the efficacy of intrabone single-unit CBT without ATG in terms of early engraftment and controllable acute graft-versus-host disease.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_9_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Springer", "subitem_publisher_language": "en"}]}, "item_9_relation_43": {"attribute_name": "\u95a2\u9023\u60c5\u5831", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1007/s00277-020-04365-z", "subitem_relation_type_select": "DOI"}}]}, "item_9_source_id_7": {"attribute_name": "\u53ce\u9332\u7269\u8b58\u5225\u5b50", "attribute_value_mlt": [{"subitem_source_identifier": "0939-5555", "subitem_source_identifier_type": "PISSN"}]}, "item_access_right": {"attribute_name": "\u30a2\u30af\u30bb\u30b9\u6a29", "attribute_value_mlt": 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"Sugita, Junichi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ikeda, Takashi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kuwatsuka, Yachiyo", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Suzuki, Ritsuro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Najima, Yuho", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Doki, Noriko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kato, Tomonori", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Inagaki, Yuichiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Utsu, Yoshikazu", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Aotsuka, Nobuyuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Masuko, Masayoshi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Terakura, Seitaro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Onishi, Yasushi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Maeda, Yoshinobu", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Okada, Masaya", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Teshima, Takanori", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Murata, Makoto", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2022-03-01"}], "displaytype": "detail", "download_preview_message": "Download / Preview is available from 2022/2/28.", "file_order": 0, "filename": "Ann_Hematol_2021.pdf", "filesize": [{"value": "351 KB"}], "format": "application/pdf", "future_date_message": "Download is available from 2022/2/28.", "is_thumbnail": false, "mimetype": "application/pdf", "size": 351000.0, "url": {"objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/2001431/files/Ann_Hematol_2021.pdf"}, "version_id": "1524d7d8-fe0d-44ae-80cf-ab3d053b3dd6"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "cord blood transplantation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "intrabone, engraftment", "subitem_subject_scheme": "Other"}, {"subitem_subject": "graft-versus-host disease", "subitem_subject_scheme": "Other"}, {"subitem_subject": "antithymocyte globulin", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "A multicenter phase II study of intrabone single-unit cord blood transplantation without antithymocyte globulin", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "A multicenter phase II study of intrabone single-unit cord blood transplantation without antithymocyte globulin", "subitem_title_language": "en"}]}, "item_type_id": "40001", "owner": "17", "path": ["320/321/322"], "permalink_uri": "http://hdl.handle.net/2237/0002001431", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2021-09-13"}, "publish_date": "2021-09-13", "publish_status": "0", "recid": "2001431", "relation": {}, "relation_version_is_last": true, "title": ["A multicenter phase II study of intrabone single-unit cord blood transplantation without antithymocyte globulin"], "weko_shared_id": -1}