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  1. B200 工学部/工学研究科
  2. B200a 雑誌掲載論文
  3. 学術雑誌

A multicenter phase II study of intrabone single-unit cord blood transplantation without antithymocyte globulin

http://hdl.handle.net/2237/0002001431
http://hdl.handle.net/2237/0002001431
9c0bce0a-b5e2-40e6-861d-f553ddf00b76
名前 / ファイル ライセンス アクション
Ann_Hematol_2021.pdf Ann_Hematol_2021.pdf (351 KB)
Item type itemtype_ver1(1)
公開日 2021-09-13
タイトル
タイトル A multicenter phase II study of intrabone single-unit cord blood transplantation without antithymocyte globulin
言語 en
著者 Nishida, Tetsuya

× Nishida, Tetsuya

en Nishida, Tetsuya

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Kobayashi, Takeshi

× Kobayashi, Takeshi

en Kobayashi, Takeshi

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Sawa, Masashi

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en Sawa, Masashi

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Masuda, Shinichi

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en Masuda, Shinichi

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Shibasaki, Yasuhiko

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en Shibasaki, Yasuhiko

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Goto, Tatsunori

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en Goto, Tatsunori

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Fukuhara, Noriko

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en Fukuhara, Noriko

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Fujii, Nobuharu

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en Fujii, Nobuharu

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Ikegame, Kazuhiro

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en Ikegame, Kazuhiro

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Sugita, Junichi

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en Sugita, Junichi

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Ikeda, Takashi

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Kuwatsuka, Yachiyo

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en Kuwatsuka, Yachiyo

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Suzuki, Ritsuro

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en Suzuki, Ritsuro

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Najima, Yuho

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en Najima, Yuho

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Doki, Noriko

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Kato, Tomonori

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en Kato, Tomonori

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Inagaki, Yuichiro

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en Inagaki, Yuichiro

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Utsu, Yoshikazu

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en Utsu, Yoshikazu

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Aotsuka, Nobuyuki

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en Aotsuka, Nobuyuki

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Masuko, Masayoshi

× Masuko, Masayoshi

en Masuko, Masayoshi

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Terakura, Seitaro

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en Terakura, Seitaro

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Onishi, Yasushi

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en Onishi, Yasushi

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Maeda, Yoshinobu

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en Maeda, Yoshinobu

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Okada, Masaya

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en Okada, Masaya

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Teshima, Takanori

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Murata, Makoto

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
キーワード
主題Scheme Other
主題 cord blood transplantation
キーワード
主題Scheme Other
主題 intrabone, engraftment
キーワード
主題Scheme Other
主題 graft-versus-host disease
キーワード
主題Scheme Other
主題 antithymocyte globulin
内容記述
内容記述 To overcome the delayed or failed engraftment after unrelated cord blood transplantation (CBT), we conducted a multicenter phase II study of intrabone single-unit CBT without antithymocyte globulin (ATG) for adult patients with hematological malignancies (UMIN-CTR, UMIN000020997). Sixty-four patients received an intrabone injection of unwashed (n = 61) or washed (n = 3) cord blood after local anesthesia. All injection-related adverse events were mild and resolved spontaneously. Sixty-two patients were evaluable for the efficacy of intrabone CBT of serological HLA-A, -B, and -DR ≥ 4/6 matched cord blood with a median number of 2.57 × 10^7/kg cryopreserved total nucleated cells. The probability of survival with neutrophil engraftment on day 28 was 77.4% (95% confidence interval, 67.0–85.8%), which exceeded the threshold value. The cumulative incidences of neutrophils ≥ 0.5 × 10^9/L on day 60 was 80.6% (68.2–88.6%), with a median time to recovery of 21 days after transplantation. The cumulative incidences of platelets ≥ 20 × 10^9/L and platelets ≥ 50 × 10^9/L on day 100 were 75.8% (62.6–84.9%) and 72.6% (59.4–82.1%), respectively, with median time to platelets ≥ 20 × 10^9/L and platelets ≥ 50 × 10^9/L of 38 and 45 days after transplantation, respectively. The cumulative incidences of grade II–IV and III–IV acute graft-versus-host disease were 29.0% and 6.5%, respectively. All responded to steroid therapy, and secondary treatments were not required. The present study suggests the efficacy of intrabone single-unit CBT without ATG in terms of early engraftment and controllable acute graft-versus-host disease.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Springer
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
関連情報
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s00277-020-04365-z
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 0939-5555
書誌情報 en : Annals of Hematology

巻 100, 号 3, p. 743-752, 発行日 2021-03
ファイル公開日
日付 2022-03-01
日付タイプ Available
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