{"_buckets": {"deposit": "8611da20-18e5-4a29-8d45-74978b4f6f6c"}, "_deposit": {"id": "2001651", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2001651"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:02001651", "sets": ["1638493189962"]}, "author_link": [], "control_number": "2001651", "item_1615768549627": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_1615768833594": {"attribute_name": "助成情報", "attribute_value_mlt": [{"subitem_award_numbers": {"subitem_award_number": "16H05413", "subitem_award_uri": "https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H05413/"}, "subitem_award_titles": [{"subitem_award_title": "HF10ウイルスの抗腫瘍効果における新たな免疫因子の役割", "subitem_award_title_language": "ja"}], "subitem_funder_names": [{"subitem_funder_name": "日本学術振興会", "subitem_funder_name_language": "ja"}, {"subitem_funder_name": "Japan Society for the Promotion of Science", "subitem_funder_name_language": "en"}]}, {"subitem_award_numbers": {"subitem_award_number": "16K15611", "subitem_award_uri": "https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K15611/"}, "subitem_award_titles": [{"subitem_award_title": "革新的な腫瘍抗原ウイルスとTCR遺伝子改変T細胞の併用療法の開発", "subitem_award_title_language": "ja"}], "subitem_funder_names": [{"subitem_funder_name": "日本学術振興会", "subitem_funder_name_language": "ja"}, {"subitem_funder_name": "Japan Society for the Promotion of Science", "subitem_funder_name_language": "en"}]}]}, "item_9_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2021-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "696", "bibliographicPageStart": "683", "bibliographicVolumeNumber": "83", "bibliographic_titles": [{"bibliographic_title": "Nagoya Journal of Medical Science", "bibliographic_titleLang": "en"}]}]}, "item_9_description_4": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "Canerpaturev (C-REV) is a highly attenuated, replication-competent, mutant strain of oncolytic herpes simplex virus type 1 that may be an effective new cancer treatment option. S-1, an oral formulation containing the 5-fluorouracil (5-FU) prodrug tegafur and the two enzyme modulators gimeracil and oteracil, is used as a key chemotherapeutic agent for metastatic recurrent breast cancer. Although the antitumor effects of oncolytic viruses combined with 5-FU in vivo have been reported, the detailed mechanisms are unknown. Here, we investigated the antitumor mechanism of the combination of C-REV and S-1 in triple-negative breast cancer (TNBC) in the context of tumor immunity. The combined effect of C-REV and S-1 was evaluated in a bilateral tumor model of murine TNBC 4T1 in vivo. S-1 enhanced the TNBC growth inhibitory effects of C-REV, and decreased the number of tumor-infiltrating, myeloid-derived suppressor cells (MDSCs), which suppress both innate and adaptive immune responses. Moreover, C-REV alone and in combination with S-1 significantly increased the number of CD8+ T cells in the tumor and the production of interferon γ (IFNγ) from these cells. Our findings indicate that C-REV suppresses TNBC tumor growth by inducing the expansion of effector CD8+ T cell subsets in tumors in which S-1 can inhibit MDSC function. Our study suggests that MDSCs may be an important cellular target for breast cancer treatment. The combination of C-REV and S-1 is a new approach that might be directly translated into future clinical trials against TNBC.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}, {"subitem_description": "This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (http://creativecommons.org/licenses/by-nc-nd/4.0/).", "subitem_description_language": "en", "subitem_description_type": "Other"}]}, "item_9_identifier_registration": {"attribute_name": "ID登録", "attribute_value_mlt": [{"subitem_identifier_reg_text": "10.18999/nagjms.83.4.683", "subitem_identifier_reg_type": "JaLC"}]}, "item_9_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Nagoya University Graduate School of Medicine, School of Medicine", "subitem_publisher_language": "en"}]}, "item_9_relation_43": {"attribute_name": "関連情報", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/834.html", "subitem_relation_type_select": "URI"}}]}, "item_9_source_id_7": {"attribute_name": "収録物識別子", "attribute_value_mlt": [{"subitem_source_identifier": "0027-7622", "subitem_source_identifier_type": "PISSN"}, {"subitem_source_identifier": "2186-3326", "subitem_source_identifier_type": "EISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Miyajima, Noriyuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ragab Eissa, Ibrahim", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Abdelmoneim, Mohamed", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Naoe, Yoshinori", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ichinose, Toru", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Matsumura, Shigeru", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Bustos-Villalobos, Itzel", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Mukoyama, Nobuaki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Morimoto, Daishi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Shibata, Masahiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Takeuchi, Dai", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Tsunoda, Nobuyuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kikumori, Toyone", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Tanaka, Maki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kodera, Yasuhiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Kasuya, Hideki", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2021-12-03"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "04_Miyajima.pdf", "filesize": [{"value": "1.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "application/pdf", "size": 1400000.0, "url": {"objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/2001651/files/04_Miyajima.pdf"}, "version_id": "627ae227-7fd0-4d2f-ab93-6edeac5f1d9f"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "oncolytic virus", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "canerpaturev", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "S-1", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "myeloid-derived suppressor cells", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "S-1 facilitates canerpaturev (C-REV)-induced antitumor efficacy in a triple-negative breast cancer model", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "S-1 facilitates canerpaturev (C-REV)-induced antitumor efficacy in a triple-negative breast cancer model", "subitem_title_language": "en"}]}, "item_type_id": "40001", "owner": "1", "path": ["1638493189962"], "permalink_uri": "https://doi.org/10.18999/nagjms.83.4.683", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2021-12-03"}, "publish_date": "2021-12-03", "publish_status": "0", "recid": "2001651", "relation": {}, "relation_version_is_last": true, "title": ["S-1 facilitates canerpaturev (C-REV)-induced antitumor efficacy in a triple-negative breast cancer model"], "weko_shared_id": -1}