{"_buckets": {"deposit": "1f3abfb1-a4a8-420f-9d52-2d5b6e197d7e"}, "_deposit": {"created_by": 17, "id": "2002096", "owner": "17", "owners": [17], "owners_ext": {"displayname": "図書情報係", "username": "repository"}, "pid": {"revision_id": 0, "type": "depid", "value": "2002096"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:02002096", "sets": ["667"]}, "author_link": [], "control_number": "2002096", "item_1615768549627": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_1629683748249": {"attribute_name": "日付", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2022-02-14", "subitem_date_issued_type": "Available"}]}, "item_9_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "11", "bibliographicPageStart": "bqaa161", "bibliographicVolumeNumber": "161", "bibliographic_titles": [{"bibliographic_title": "Endocrinology", "bibliographic_titleLang": "en"}]}]}, "item_9_description_4": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "Malnutrition suppresses reproductive functions in mammals, which is considered to be mostly due to the inhibition of pulsatile gonadotropin-releasing hormone (GnRH)/gonadotropin secretion. Accumulating evidence suggests that kisspeptin neurons in the arcuate nucleus (ARC) play a critical role in the regulation of pulsatile GnRH/gonadotropin release. The present study aimed to examine if the hypothalamic dynorphin A (Dyn) neurons mediate the suppression of GnRH/luteinizing hormone (LH) pulses during malnutrition. Ovariectomized rats treated with a negative feedback level of estradiol-17β-treated (OVX+E2) were administered with intravenous (iv) or fourth cerebroventricle (4V) 2-deoxy-D-glucose (2DG), an inhibitor of glucose utilization, to serve as a malnutrition model. Central administration of a Dyn receptor antagonist blocked the iv- or 4V-2DG-induced suppression of LH pulses in OVX+E2 rats. The 4V 2DG administration significantly increased the number of Pdyn (Dyn gene)-positive cells co-expressing fos in the paraventricular nucleus (PVN), but not in the ARC and supraoptic nucleus (SON), and the iv 2DG treatment significantly increased the number of fos and Pdyn-co-expressing cells in the PVN and SON, but decreased it in the ARC. The E2 treatment significantly increased Pdyn expression in the PVN, but not in the ARC and SON. Double in situ hybridization for Kiss1 (kisspeptin gene) and Oprk1 (Dyn receptor gene) revealed that around 60% of ARC Kiss1-expressing cells co-expressed Oprk1. These results suggest that the PVN Dyn neurons, at least in part, mediate LH pulse suppression induced by the hindbrain or peripheral glucoprivation, and Dyn neurons may directly suppress the ARC kisspeptin neurons in female rats.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_9_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Oxford University Press", "subitem_publisher_language": "en"}]}, "item_9_relation_43": {"attribute_name": "関連情報", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1210/endocr/bqaa161", "subitem_relation_type_select": "DOI"}}]}, "item_9_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "This is a pre-copyedited, author-produced version of an article accepted for publication in [Endocrinology] following peer review. The version of record [Hitomi Tsuchida, Parvin Mostari, Koki Yamada, Sae Miyazaki, Yuki Enomoto, Naoko Inoue, Yoshihisa Uenoyama, Hiroko Tsukamura, Paraventricular Dynorphin A Neurons Mediate LH Pulse Suppression Induced by Hindbrain Glucoprivation in Female Rats, Endocrinology, Volume 161, Issue 11, November 2020, bqaa161, https://doi.org/10.1210/endocr/bqaa161] is available online at: https://doi.org/10.1210/endocr/bqaa161.", "subitem_rights_language": "en"}]}, "item_9_source_id_7": {"attribute_name": "収録物識別子", "attribute_value_mlt": [{"subitem_source_identifier": "0013-7227", "subitem_source_identifier_type": "PISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Tsuchida, Hitomi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Mostari, Parvin", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Yamada, Koki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Miyazaki, Sae", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Enomoto, Yuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Inoue, Naoko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Uenoyama, Yoshihisa", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Tsukamura, Hiroko", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2022-02-14"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Tsuchida_et_al_2020_Endocrinology.pdf", "filesize": [{"value": "52.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "mimetype": "application/pdf", "size": 52200000.0, "url": {"objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/2002096/files/Tsuchida_et_al_2020_Endocrinology.pdf"}, "version_id": "990903f3-2428-435e-b4b1-2d1561e0dd48"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "dynorphin A receptor", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Kiss1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "malnutrition", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Paraventricular Dynorphin A Neurons Mediate LH Pulse Suppression Induced by Hindbrain Glucoprivation in Female Rats", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Paraventricular Dynorphin A Neurons Mediate LH Pulse Suppression Induced by Hindbrain Glucoprivation in Female Rats", "subitem_title_language": "en"}]}, "item_type_id": "40001", "owner": "17", "path": ["667"], "permalink_uri": "http://hdl.handle.net/2237/0002002096", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2022-02-14"}, "publish_date": "2022-02-14", "publish_status": "0", "recid": "2002096", "relation": {}, "relation_version_is_last": true, "title": ["Paraventricular Dynorphin A Neurons Mediate LH Pulse Suppression Induced by Hindbrain Glucoprivation in Female Rats"], "weko_shared_id": -1}