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  1. B300 農学部/生命農学研究科
  2. B300a 雑誌掲載論文
  3. 学術雑誌

Paraventricular Dynorphin A Neurons Mediate LH Pulse Suppression Induced by Hindbrain Glucoprivation in Female Rats

http://hdl.handle.net/2237/0002002096
http://hdl.handle.net/2237/0002002096
90188b61-f631-45fc-8042-2b78b5d4e3b4
名前 / ファイル ライセンス アクション
Tsuchida_et_al_2020_Endocrinology.pdf Tsuchida_et_al_2020_Endocrinology.pdf (52.2 MB)
Item type itemtype_ver1(1)
公開日 2022-02-14
タイトル
タイトル Paraventricular Dynorphin A Neurons Mediate LH Pulse Suppression Induced by Hindbrain Glucoprivation in Female Rats
言語 en
著者 Tsuchida, Hitomi

× Tsuchida, Hitomi

en Tsuchida, Hitomi

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Mostari, Parvin

× Mostari, Parvin

en Mostari, Parvin

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Yamada, Koki

× Yamada, Koki

en Yamada, Koki

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Miyazaki, Sae

× Miyazaki, Sae

en Miyazaki, Sae

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Enomoto, Yuki

× Enomoto, Yuki

en Enomoto, Yuki

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Inoue, Naoko

× Inoue, Naoko

en Inoue, Naoko

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Uenoyama, Yoshihisa

× Uenoyama, Yoshihisa

en Uenoyama, Yoshihisa

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Tsukamura, Hiroko

× Tsukamura, Hiroko

en Tsukamura, Hiroko

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is a pre-copyedited, author-produced version of an article accepted for publication in [Endocrinology] following peer review. The version of record [Hitomi Tsuchida, Parvin Mostari, Koki Yamada, Sae Miyazaki, Yuki Enomoto, Naoko Inoue, Yoshihisa Uenoyama, Hiroko Tsukamura, Paraventricular Dynorphin A Neurons Mediate LH Pulse Suppression Induced by Hindbrain Glucoprivation in Female Rats, Endocrinology, Volume 161, Issue 11, November 2020, bqaa161, https://doi.org/10.1210/endocr/bqaa161] is available online at: https://doi.org/10.1210/endocr/bqaa161.
キーワード
主題Scheme Other
主題 dynorphin A receptor
キーワード
主題Scheme Other
主題 Kiss1
キーワード
主題Scheme Other
主題 malnutrition
内容記述
内容記述 Malnutrition suppresses reproductive functions in mammals, which is considered to be mostly due to the inhibition of pulsatile gonadotropin-releasing hormone (GnRH)/gonadotropin secretion. Accumulating evidence suggests that kisspeptin neurons in the arcuate nucleus (ARC) play a critical role in the regulation of pulsatile GnRH/gonadotropin release. The present study aimed to examine if the hypothalamic dynorphin A (Dyn) neurons mediate the suppression of GnRH/luteinizing hormone (LH) pulses during malnutrition. Ovariectomized rats treated with a negative feedback level of estradiol-17β-treated (OVX+E2) were administered with intravenous (iv) or fourth cerebroventricle (4V) 2-deoxy-D-glucose (2DG), an inhibitor of glucose utilization, to serve as a malnutrition model. Central administration of a Dyn receptor antagonist blocked the iv- or 4V-2DG-induced suppression of LH pulses in OVX+E2 rats. The 4V 2DG administration significantly increased the number of Pdyn (Dyn gene)-positive cells co-expressing fos in the paraventricular nucleus (PVN), but not in the ARC and supraoptic nucleus (SON), and the iv 2DG treatment significantly increased the number of fos and Pdyn-co-expressing cells in the PVN and SON, but decreased it in the ARC. The E2 treatment significantly increased Pdyn expression in the PVN, but not in the ARC and SON. Double in situ hybridization for Kiss1 (kisspeptin gene) and Oprk1 (Dyn receptor gene) revealed that around 60% of ARC Kiss1-expressing cells co-expressed Oprk1. These results suggest that the PVN Dyn neurons, at least in part, mediate LH pulse suppression induced by the hindbrain or peripheral glucoprivation, and Dyn neurons may directly suppress the ARC kisspeptin neurons in female rats.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Oxford University Press
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
関連情報
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1210/endocr/bqaa161
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 0013-7227
書誌情報 en : Endocrinology

巻 161, 号 11, p. bqaa161, 発行日 2020-11
ファイル公開日
日付 2022-02-14
日付タイプ Available
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