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The molecular understanding of super-enhancer dysregulation in cancer
https://doi.org/10.18999/nagjms.84.2.216
https://doi.org/10.18999/nagjms.84.2.216a8068728-09b3-43b1-a03a-32c943778b45
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
02_Yoshino.pdf (2.9 MB)
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| Item type | itemtype_ver1(1) | |||||||||
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| 公開日 | 2022-05-27 | |||||||||
| タイトル | ||||||||||
| タイトル | The molecular understanding of super-enhancer dysregulation in cancer | |||||||||
| 言語 | en | |||||||||
| 著者 |
Yoshino, Seiko
× Yoshino, Seiko
× Suzuki, Hiroshi I.
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| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 権利 | ||||||||||
| 言語 | en | |||||||||
| 権利情報Resource | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||
| 権利情報 | Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | super-enhancer | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | oncogene | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | transcription factor | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | genome | |||||||||
| キーワード | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | cancer therapy | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Abnormalities in the regulation of gene expression are associated with various pathological conditions. Among the distal regulatory elements in the genome, the activation of target genes by enhancers plays a central role in the formation of cell type–specific gene expression patterns. Super-enhancers are a subclass of enhancers that frequently contain multiple enhancer-like elements and are characterized by dense binding of master transcription factors and Mediator complexes and high signals of active histone marks. Super-enhancers have been studied in detail as important regulatory regions that control cell identity and contribute to the pathogenesis of diverse diseases. In cancer, super-enhancers have multifaceted roles by activating various oncogenes and other cancer-related genes and shaping characteristic gene expression patterns in cancer cells. Alterations in super-enhancer activities in cancer involve multiple mechanisms, including the dysregulation of transcription factors and the super-enhancer–associated genomic abnormalities. The study of super-enhancers could contribute to the identification of effective biomarkers and the development of cancer therapeutics targeting transcriptional addiction. In this review, we summarize the roles of super-enhancers in cancer biology, with a particular focus on hematopoietic malignancies, in which multiple super-enhancer alteration mechanisms have been reported. | |||||||||
| 言語 | en | |||||||||
| 出版者 | ||||||||||
| 出版者 | Nagoya University Graduate School of Medicine, School of Medicine | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| ID登録 | ||||||||||
| ID登録 | 10.18999/nagjms.84.2.216 | |||||||||
| ID登録タイプ | JaLC | |||||||||
| 関連情報 | ||||||||||
| 関連タイプ | isVersionOf | |||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/842.html | |||||||||
| 助成情報 | ||||||||||
| 助成機関識別子タイプ | Crossref Funder | |||||||||
| 助成機関識別子 | https://doi.org/10.13039/501100001691 | |||||||||
| 助成機関名 | 日本学術振興会 | |||||||||
| 言語 | ja | |||||||||
| 助成機関名 | Japan Society for the Promotion of Science | |||||||||
| 言語 | en | |||||||||
| 研究課題番号URI | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K16318/ | |||||||||
| 研究課題番号 | 20K16318 | |||||||||
| 研究課題名 | Trib1のエンハンサーリプログラミングによるAML悪性化機構の解明 | |||||||||
| 言語 | ja | |||||||||
| 助成情報 | ||||||||||
| 助成機関識別子タイプ | Crossref Funder | |||||||||
| 助成機関識別子 | https://doi.org/10.13039/501100001691 | |||||||||
| 助成機関名 | 日本学術振興会 | |||||||||
| 言語 | ja | |||||||||
| 助成機関名 | Japan Society for the Promotion of Science | |||||||||
| 言語 | en | |||||||||
| 研究課題番号URI | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K24694/ | |||||||||
| 研究課題番号 | 19K24694 | |||||||||
| 研究課題名 | ゲノム相分離生物学の創出とがん研究への応用 | |||||||||
| 言語 | ja | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 0027-7622 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | EISSN | |||||||||
| 収録物識別子 | 2186-3326 | |||||||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 84, 号 2, p. 216-229, 発行日 2022-05 |
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