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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Decreased hearing levels at frequencies for understanding speech in tannery workers exposed to a high level of trivalent chromium in Bangladesh

http://hdl.handle.net/2237/0002004232
http://hdl.handle.net/2237/0002004232
4dcd214e-fbd0-4243-8b0f-f3ffb039cdd9
名前 / ファイル ライセンス アクション
Gu_et_al_Chemosphere_2022_Manuscript_Final_version.pdf Gu_et_al_Chemosphere_2022_Manuscript_Final_version.pdf (2.2 MB)
 Download is available from 2024/10/31.
Supplementary_figures_Gu_et_al_Chemosphere_2022.pdf Supplementary_figures_Gu_et_al_Chemosphere_2022.pdf (649 KB)
 Download is available from 2024/10/31.
Item type itemtype_ver1(1)
公開日 2022-11-30
タイトル
タイトル Decreased hearing levels at frequencies for understanding speech in tannery workers exposed to a high level of trivalent chromium in Bangladesh
言語 en
著者 Gu, Yishuo

× Gu, Yishuo

en Gu, Yishuo

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Ohgami, Nobutaka

× Ohgami, Nobutaka

en Ohgami, Nobutaka

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Al Hossain, M.M. Aeorangajeb

× Al Hossain, M.M. Aeorangajeb

en Al Hossain, M.M. Aeorangajeb

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Tazaki, Akira

× Tazaki, Akira

en Tazaki, Akira

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Tsuchiyama, Tomoyuki

× Tsuchiyama, Tomoyuki

en Tsuchiyama, Tomoyuki

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He, Tingchao

× He, Tingchao

en He, Tingchao

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Aoki, Masayo

× Aoki, Masayo

en Aoki, Masayo

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Ahsan, Nazmul

× Ahsan, Nazmul

en Ahsan, Nazmul

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Akhand, Anwarul Azim

× Akhand, Anwarul Azim

en Akhand, Anwarul Azim

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Kato, Masashi

× Kato, Masashi

en Kato, Masashi

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アクセス権
アクセス権 embargoed access
アクセス権URI http://purl.org/coar/access_right/c_f1cf
権利
言語 en
権利情報 © 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
内容記述
内容記述 Hexavalent chromium [Cr(VI)], which has a strong corrosive effect, has been reported to cause perforation of the eardrum. Trivalent chromium [Cr(III)] also has a weak corrosive effect. However, there has been no study on the effects of exposure to Cr, either Cr(VI) or Cr(III), on hearing levels in animals or humans. In this study, the effect of Cr(III) exposure on hearing levels was determined in a human study. Then the reproducibility of the results obtained in the human study and the etiology were investigated in an animal study. The mean levels of total chromium (t-Cr) in hair and toenails from 100 Bangladeshi tannery workers were >20-fold and >360-fold higher, respectively, than those in hair and toenails from 49 Bangladeshi non-tannery workers (office workers). Multivariate analysis revealed decreases of hearing levels (DHLs) at 1 k and 4 k Hz, frequencies that are crucial for understanding language, but not at 8 k and 12 k Hz, in the tannery workers. Since >99.99% of t-Cr in the wastewater that the workers were in direct contact with in the tanneries was Cr(III), the epidemiological results suggest Cr(III)-mediated DHLs in the tannery workers. The results of animal experiments in this study further showed that treatment with eardrops but not intraperitoneal injection with the same amount of Cr(III) that tannery workers might be exposed to resulted in DHL with a damaged eardrum in mice. Previous studies suggested that Cr(III) can directly reach the eardrums of tannery workers via droplets in the air. Cr(III) could also reach the eardrum via picking an ear canal with a finger contaminated with tannery wastewater including Cr(III). Taken together, the results of both human and animal studies suggest the risk of DHLs caused by damage of the eardrum through external exposure to Cr(III) via the ear canal.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
関連情報
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.chemosphere.2022.135571
収録物識別子
収録物識別子タイプ PISSN
収録物識別子 0045-6535
書誌情報 en : Chemosphere

巻 306, p. 135571, 発行日 2022-11
ファイル公開日
日付 2024-11-01
日付タイプ Available
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