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Real-world effectiveness of ustekinumab for patients with ulcerative colitis: a systematic review and meta-analysis
https://doi.org/10.18999/nagjms.85.3.402
https://doi.org/10.18999/nagjms.85.3.402294884d2-3154-4b0b-ac80-cba82b229e12
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
01_Uchida.pdf (1.4 MB)
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| Item type | itemtype_ver1(1) | |||||||||||||||
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| 公開日 | 2023-08-30 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Real-world effectiveness of ustekinumab for patients with ulcerative colitis: a systematic review and meta-analysis | |||||||||||||||
| 言語 | en | |||||||||||||||
| 著者 |
Uchida, Genta
× Uchida, Genta
× Nakamura, Masanao
× Yamamura, Takeshi
× Tsuzuki, Tomoyuki
× Kawashima, Hiroki
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| アクセス権 | ||||||||||||||||
| アクセス権 | open access | |||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||
| 権利 | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 権利情報Resource | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||||||||
| 権利情報 | Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | ustekinumab | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | ulcerative colitis | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | systematic review | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | meta-analysis | |||||||||||||||
| 内容記述 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | Ustekinumab has recently been approved for the treatment of ulcerative colitis (UC) based on data from clinical trials. However, the effectiveness of ustekinumab in patients with UC in a real-world setting remains unclear. Hence, in this meta-analysis, we aimed to evaluate the effectiveness of ustekinumab in a real-world setting and to investigate the predictors of its effectiveness. A comprehensive literature search was performed to examine the effectiveness of ustekinumab in UC patients admitted between January 2019 and December 2021. Data on clinical remission, response, and corticosteroid-free clinical remission rates were extracted, pooled, and analyzed. Meta-regression analysis was performed to investigate the source of heterogeneity and the impact of moderators on the outcomes of interest. A total of 14 eligible studies were identified. The pooled clinical remission rate was 55.0% at week 8, 36.1% at week 16, 46.6% at month 6, and 38.6% at month 12. The meta-regression analysis showed that prior use of anti-tumor necrosis factor (TNF) agents and vedolizumab and the publication style were significant moderators. Additionally, out of 258 patients, there were 28 adverse events (AEs) (10.9%). The effectiveness of ustekinumab in real-world patients with UC was consistent with the results clinical trials. Moreover, previous treatment with anti-TNF agents and vedolizumab might have affected the effectiveness of ustekinumab. | |||||||||||||||
| 言語 | en | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | Nagoya University Graduate School of Medicine, School of Medicine | |||||||||||||||
| 言語 | en | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| タイプ | departmental bulletin paper | |||||||||||||||
| 出版タイプ | ||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||
| ID登録 | ||||||||||||||||
| ID登録 | 10.18999/nagjms.85.3.402 | |||||||||||||||
| ID登録タイプ | JaLC | |||||||||||||||
| 関連情報 | ||||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||||
| 識別子タイプ | URI | |||||||||||||||
| 関連識別子 | https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/853.html | |||||||||||||||
| 収録物識別子 | ||||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||||
| 収録物識別子 | 0027-7622 | |||||||||||||||
| 収録物識別子 | ||||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||||
| 収録物識別子 | 2186-3326 | |||||||||||||||
| 書誌情報 |
en : Nagoya Journal of Medical Science 巻 85, 号 3, p. 402-427, 発行日 2023-08 |
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