| Item type |
itemtype_ver1(1) |
| 公開日 |
2023-12-04 |
| タイトル |
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|
タイトル |
T cell receptor-engineered T cells derived from target human leukocyte antigen-DPB1-specific T cell can be a potential tool for therapy against leukemia relapse following allogeneic hematopoietic cell transplantation |
|
言語 |
en |
| 著者 |
Katsuyama, Naoya
Kawase, Takakazu
Barakat, Carolyne
Mizuno, Shohei
Tomita, Akihiro
Ozeki, Kazutaka
Nishio, Nobuhiro
Sato, Yoshie
Kajiya, Ryoko
Shiraishi, Keiko
Takahashi, Yoshiyuki
Ichinohe, Tatsuo
Nishikawa, Hiroyoshi
Akatsuka, Yoshiki
|
| アクセス権 |
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|
アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利 |
|
|
言語 |
en |
|
権利情報Resource |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
|
権利情報 |
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
TCR-T |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
GVHD |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
leukemia |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
allogeneic transplantation |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Human leukocyte antigen (HLA)-DPB1 antigens are mismatched in approximately 70% of allogeneic hematopoietic stem cell transplantations (allo-HSCT) from HLA 10/10 matched unrelated donors. HLA-DP-mismatched transplantation was shown to be associated with an increase in acute graft-versus-host disease (GVHD) and a decreased risk of leukemia relapse due to the graft-versus-leukemia (GVL) effect. Immunotherapy targeting mismatched HLA-DP is considered reasonable to treat leukemia following allo-HCT if performed under non-inflammatory conditions. Therefore, we isolated CD4^+ T cell clones that recognize mismatched HLA-DPB1 from healthy volunteer donors and generated T cell receptor (TCR)-gene-modified T cells for future clinical applications. Detailed analysis of TCR-T cells expressing TCR from candidate clone #17 demonstrated specificity to myeloid and monocytic leukemia cell lines that even expressed low levels of targeted HLA-DP. However, they did not react to non-hematopoietic cell lines with a substantial level of targeted HLA-DP expression, suggesting that the TCR recognized antigenic peptide is only present in some hematopoietic cells. This study demonstrated that induction of T cells specific for HLA-DP, consisting of hematopoietic cell lineage-derived peptide and redirection of T cells with cloned TCR cDNA by gene transfer, is feasible when using careful specificity analysis. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Nagoya University Graduate School of Medicine, School of Medicine |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
|
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資源タイプresource |
http://purl.org/coar/resource_type/c_6501 |
|
タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| ID登録 |
|
|
ID登録 |
10.18999/nagjms.85.4.779 |
|
ID登録タイプ |
JaLC |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
URI |
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|
関連識別子 |
https://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/854.html |
| 助成情報 |
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|
識別子タイプ |
Crossref Funder |
|
|
助成機関識別子 |
https://doi.org/10.13039/501100001691 |
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|
助成機関名 |
日本学術振興会 |
|
|
言語 |
ja |
|
|
助成機関名 |
Japan Society for the Promotion of Science |
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|
言語 |
en |
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研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K08341/ |
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研究課題番号 |
18K08341 |
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研究課題名 |
不適合HLA抗原を標的とした移植後再発に対するTCR導入T細胞療法の開発 |
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言語 |
ja |
| 助成情報 |
|
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|
識別子タイプ |
Crossref Funder |
|
|
助成機関識別子 |
https://doi.org/10.13039/501100001691 |
|
|
助成機関名 |
日本学術振興会 |
|
|
言語 |
ja |
|
|
助成機関名 |
Japan Society for the Promotion of Science |
|
|
言語 |
en |
|
|
研究課題番号URI |
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K08369/ |
|
|
研究課題番号 |
21K08369 |
|
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研究課題名 |
不適合HLA-DP抗原認識抗体を用いた移植後再発に対するCAR-T細胞の開発 |
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|
言語 |
ja |
| 収録物識別子 |
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収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0027-7622 |
| 収録物識別子 |
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収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2186-3326 |
| 書誌情報 |
en : Nagoya Journal of Medical Science
巻 85,
号 4,
p. 779-796,
発行日 2023-11
|
12_Katsuyama.pdf (4 MB)
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