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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 78(3)

Reduced molecular size and altered disaccharide composition of cerebral chondroitin sulfate upon Alzheimer’s pathogenesis in mice

https://doi.org/10.18999/nagjms.78.3.293
https://doi.org/10.18999/nagjms.78.3.293
2a95eae1-d845-40da-832e-ad9a539ab89c
名前 / ファイル ライセンス アクション
17_ZuiZhang.pdf 17_ZuiZhang.pdf (977.3 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-09-12
タイトル
タイトル Reduced molecular size and altered disaccharide composition of cerebral chondroitin sulfate upon Alzheimer’s pathogenesis in mice
著者 Zhang, Zui

× Zhang, Zui

WEKO 66739

Zhang, Zui

Search repository
Ohtake-Niimi, Shiori

× Ohtake-Niimi, Shiori

WEKO 66740

Ohtake-Niimi, Shiori

Search repository
Kadomatsu, Kenji

× Kadomatsu, Kenji

WEKO 66741

Kadomatsu, Kenji

Search repository
Uchimura, Kenji

× Uchimura, Kenji

WEKO 66742

Uchimura, Kenji

Search repository
キーワード
主題Scheme Other
主題 chondroitin sulfate
キーワード
主題Scheme Other
主題 Alzheimer’s disease
キーワード
主題Scheme Other
主題 neurodegeneration
キーワード
主題Scheme Other
主題 HPLC
抄録
内容記述 Alzheimer’s disease (AD) is a progressive disorder leading to cognitive impairment and neuronal loss. Cerebral extracellular accumulation and deposition of amyloid ß plaques is a pathological hallmark of AD. Chondroitin sulfate (CS) is an extracellular component abundant in the brain. CS is a sulfated glycosaminoglycan covalently attached to a core protein, forming chondroitin sulfate proteoglycan. The structure of CS is heterogeneous with sulfation modification and elongation of the chain. The structural diversity of CS allows it to play various roles in the brain. Increasing evidence has shown that CS promotes aggregation of amyloid ß peptides into higher-order species such as insoluble amyloid ß fibrils. Difficulties in the structural analysis of brain CS, as well as its heterogeneity, limit the study of potential roles of CS in AD pathology. Here we established a microanalysis method with reversed-phase ion-pair high performance liquid chromatography and found that CS in the brains of Tg2576 AD model mice show a lower molecular size and an increased ratio of CS-B motif di-sulfated disaccharide. Our findings provide insight into the structural changes of cerebral CS upon Alzheimer’s pathogenesis.
内容記述タイプ Abstract
出版者
出版者 Nagoya University Graduate School of Medicine, School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.78.3.293
ID登録タイプ JaLC
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
書誌情報 Nagoya Journal of Medical Science

巻 78, 号 3, p. 293-301, 発行日 2016-08
著者版フラグ
値 publisher
URI
識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/783.html
識別子タイプ URI
URI
識別子 http://hdl.handle.net/2237/24815
識別子タイプ HDL
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