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  1. C100 医学部/医学系研究科
  2. C100b 紀要
  3. Nagoya journal of medical science
  4. 28(1)

Peroxides as a Factor of Atherosclerosis

https://doi.org/10.18999/nagjms.28.1.50
https://doi.org/10.18999/nagjms.28.1.50
b17a2c7d-ff3b-4e1a-bb7d-0c1d734011f1
名前 / ファイル ライセンス アクション
v28n1p50_66.pdf v28n1p50_66.pdf (2.6 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-09-26
タイトル
タイトル Peroxides as a Factor of Atherosclerosis
著者 IWAKAMI, MINORU

× IWAKAMI, MINORU

WEKO 93828

IWAKAMI, MINORU

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抄録
内容記述 Fatty acid peroxides have been found in the atherosclerotic human aorta by Glavind. A correlation exists between the extent of the atherosclerotic changes and the content of lipid peroxides. It may be inferred that the presence of peroxides in the aorta brings about a disturbance in the function of the arterial wall and gives rise to atherosclerotic changes. Vitamin E, which prevents the peroxidation of lipids, might suppress the atherogenesis. X-ray irradiation, which induces the auto-oxidation of lipids, might promote the process of the atherogenesis. From these considerations, the present investigation was performed. The determinations of peroxides were carried out on the rabbit aorta by the ammonium thiocyanate method. A correlation existed between the extent of the atherosclerotic changes and the content of lipid peroxides. The aortas with no atherosclerotic changes contained only small amount of peroxides. Peroxides of the rabbit aorta were determined by the method of TBA. Vitamin E injection prevented the lipid peroxidation in the aortas and livers. Furthermore, Vitamin E suppressed the atherosclerotic changes. Peroxides were produced by X-ray irradiation in the aortic wall and liver of the rabbit. Whole body X-ray irradiation promoted the progress of atherosclerotic changes in cholesterol fed rabbit, and produced atheroma-like plaque in the thoracic aorta of the rabbit. The respiration of the aorta of rat was decreased by peroxides added in the diet. However, the respiration of liver was not influenced. The activity of cytochrome oxidase was more inhibited than that of succinic dehydrogenase. In vitro effect of peroxides on the respiration of the aorta of rats was also observed.
内容記述タイプ Abstract
出版者
出版者 Nagoya University School of Medicine
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
ID登録
ID登録 10.18999/nagjms.28.1.50
ID登録タイプ JaLC
関連情報
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/281/281.html
ISSN(print)
収録物識別子タイプ ISSN
収録物識別子 0027-7622
ISSN(Online)
収録物識別子タイプ ISSN
収録物識別子 2186-3326
書誌情報 Nagoya Journal of Medical Science

巻 28, 号 1, p. 50-66, 発行日 1965-12
著者版フラグ
値 publisher
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