{"_buckets": {"deposit": "baae5be1-8ee3-4d1e-a300-f450637ea04e"}, "_deposit": {"id": "22726", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "22726"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00022726", "sets": ["696"]}, "author_link": ["66892", "66893", "66894", "66895", "66896", "66897", "66898", "66899", "66900", "66901"], "item_10_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2016-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "12", "bibliographicPageEnd": "1817", "bibliographicPageStart": "1803", "bibliographicVolumeNumber": "36", "bibliographic_titles": [{"bibliographic_title": "MOLECULAR AND CELLULAR BIOLOGY", "bibliographic_titleLang": "en"}]}]}, "item_10_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "pVHL, the protein product of the von Hippel-Lindau (VHL) tumor suppressor gene, is a ubiquitin ligase that targets hypoxia-inducible factor α (HIF-α) for proteasomal degradation. Although HIF-α activation is necessary for VHL disease pathogenesis, constitutive activation of HIF-α alone did not induce renal clear cell carcinomas and pheochromocytomas in mice, suggesting the involvement of an HIF-α-independent pathway in VHL pathogenesis. Here, we show that the transcription factor B-Myb is a pVHL substrate that is degraded via the ubiquitin-proteasome pathway and that vascular endothelial growth factor (VEGF)- and/or platelet-derived growth factor (PDGF)-dependent tyrosine 15 phosphorylation of B-Myb prevents its degradation. Mice injected with B-Myb knockdown 786-O cells developed dramatically larger tumors than those bearing control cell tumors. Microarray screening of B-Myb-regulated genes showed that the expression of HIF-α-dependent genes was not affected by B-Myb knockdown, indicating that B-Myb prevents HIF-α-dependent tumorigenesis through an HIF-α-independent pathway. These data indicate that the regulation of B-Myb by pVHL plays a critical role in VHL disease.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_10_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "DOI", "subitem_identifier_uri": "http://doi.org/10.1128/MCB.00067-16"}, {"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/24879"}]}, "item_10_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "American Society for Microbiology", "subitem_publisher_language": "en"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1128/MCB.00067-16", "subitem_relation_type_select": "DOI"}}]}, "item_10_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_10_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0270-7306", "subitem_source_identifier_type": "PISSN"}]}, "item_1615787544753": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Okumura, Fumihiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "66892", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Uematsu, Keiji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "66893", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Byrne, Stuart D.", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "66894", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirano, Mie", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "66895", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Joo-Okumura, Akiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "66896", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishikimi, Akihiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "66897", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shuin, Taro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "66898", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fukui, Yoshinori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "66899", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakatsukasa, Kunio", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "66900", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kamura, Takumi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "66901", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-02-22"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Mol_Cell_Biol_2016-Okumura-1803-17.pdf", "filesize": [{"value": "1.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 1800000.0, "url": {"label": "Mol_Cell_Biol_2016-Okumura-1803-17.pdf", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/22726/files/Mol_Cell_Biol_2016-Okumura-1803-17.pdf"}, "version_id": 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["Parallel Regulation of von Hippel-Lindau Disease by pVHL-Mediated Degradation of B-Myb and Hypoxia-Inducible Factor α"], "weko_shared_id": -1}