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Constitutively expressed Siglec-9 inhibits LPS-induced CCR7, but enhances IL-4-induced CD200R expression in human macrophages
http://hdl.handle.net/2237/25146
http://hdl.handle.net/2237/25146b2f9e98c-a04c-448d-9c21-bdd79ac3c8a2
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Higuchi_et_al.pdf ファイル公開：2017/03/01 (2.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-12-05 | |||||
| タイトル | ||||||
| タイトル | Constitutively expressed Siglec-9 inhibits LPS-induced CCR7, but enhances IL-4-induced CD200R expression in human macrophages | |||||
| 言語 | en | |||||
| 著者 |
Higuchi, Hiroshi
× Higuchi, Hiroshi× Shoji, Toru× Iijima, Shinji× Nishijima, Ken-ichi |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | ja | |||||
| 権利情報 | (c)日本農芸化学会. This is an Accepted Manuscript of an article published by Taylor & Francis Group in Bioscience, Biotechnology, and Biochemistry on 29/02/2016, available online: http://www.tandfonline.com/10.1080/09168451.2016.1146070. | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | human | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | lectin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | macrophages | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | sialic acid | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Siglec | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Siglecs recognize the sialic acid moiety and regulate various immune responses. In the present study, we compared the expression levels of Siglecs in human monocytes and macrophages using a quantitative real-time reverse transcription–polymerase chain reaction analysis. The differentiation of monocytes into macrophages by macrophage colony-stimulating factor or granulocyte macrophage colony-stimulating factor enhanced the expression of Siglec-7 and Siglec-9. The differentiated macrophages were stimulated by lipopolysaccharide (LPS) plus interferon (IFN)-γ or interleukin (IL)-4. The expression of Siglec-10 was enhanced by IL-4, whereas that of Siglec-7 was reduced by LPS plus IFN-γ. The expression of Siglec-9 was not affected by these stimuli. The knockdown of Siglec-9 enhanced the expression of CCR7 induced by the LPS or the LPS plus IFN-γ stimulation, and decreased the IL-4-induced expression of CD200R. These results suggest that Siglec-9 is one of the main Siglecs in human blood monocytes/macrophages and modulates innate immunity. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Taylor & Francis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1080/09168451.2016.1146070 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0916-8451 | |||||
| 書誌情報 |
en : Bioscience, Biotechnology, and Biochemistry 巻 80, 号 6, p. 1141-1148, 発行日 2016-02-29 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
| URI | ||||||
| 識別子 | http://doi.org/10.1080/09168451.2016.1146070 | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/25146 | |||||
| 識別子タイプ | HDL | |||||
