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Analysis on transglutaminase 1 and its substrates using specific substrate peptide in cultured keratinocytes
http://hdl.handle.net/2237/25155
8a04c0d8-cdbd-42ad-80de-4d4cf0f13f27
名前 / ファイル | ライセンス | アクション | |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2016-12-07 | |||||
タイトル | ||||||
タイトル | Analysis on transglutaminase 1 and its substrates using specific substrate peptide in cultured keratinocytes | |||||
著者 |
Yamane, Miki
× Yamane, Miki× Sugimura, Kayoko× Kawasaki, Hiroko× Tatsukawa, Hideki× Hitomi, Kiyotaka |
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権利 | ||||||
権利情報 | © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Transglutaminase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Keratinocyte | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Epidermis | |||||
抄録 | ||||||
内容記述 | Transglutaminase (TGase) catalyzes protein cross-linking reactions essential for several biological processes. In differentiating keratinocytes, TG1 (keratinocyte-type) is crucial for the cross-linking of substrate proteins required for the complete formation of the cornified envelop, a proteinaceous supermolecule located in the outermost layer of the epidermis. TG1 expressions and its substrate were induced in cultured keratinocytes at differentiation-stage specific manner. In the cultured keratinocytes, we used the TG1-specific substrate peptide, which enables the specific detection of enzymatic activity to investigate its induction patterns. As a further application of the substrate peptide, several substrate candidates of TG1 that may be essential for cornified envelope formation were identified and characterized. | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
出版者 | Elsevier | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0006-291X | |||||
書誌情報 |
Biochemical and Biophysical Research Communications 巻 478, 号 1, p. 343-348, 発行日 2016-09 |
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著者版フラグ | ||||||
値 | author | |||||
URI | ||||||
識別子 | http://dx.doi.org/10.1016/j.bbrc.2016.07.051 | |||||
識別子タイプ | DOI | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/25155 | |||||
識別子タイプ | HDL |