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  1. D400 創薬科学研究科
  2. D400a 雑誌掲載論文
  3. 学術雑誌

Analysis on transglutaminase 1 and its substrates using specific substrate peptide in cultured keratinocytes

http://hdl.handle.net/2237/25155
8a04c0d8-cdbd-42ad-80de-4d4cf0f13f27
名前 / ファイル ライセンス アクション
BBRC-S-16-06867_Redacted.pdf BBRC-S-16-06867_Redacted.pdf ファイル公開:2017/09/01 (1.3 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2016-12-07
タイトル
タイトル Analysis on transglutaminase 1 and its substrates using specific substrate peptide in cultured keratinocytes
著者 Yamane, Miki

× Yamane, Miki

WEKO 67840

Yamane, Miki

Search repository
Sugimura, Kayoko

× Sugimura, Kayoko

WEKO 67841

Sugimura, Kayoko

Search repository
Kawasaki, Hiroko

× Kawasaki, Hiroko

WEKO 67842

Kawasaki, Hiroko

Search repository
Tatsukawa, Hideki

× Tatsukawa, Hideki

WEKO 67843

Tatsukawa, Hideki

Search repository
Hitomi, Kiyotaka

× Hitomi, Kiyotaka

WEKO 67844

Hitomi, Kiyotaka

Search repository
権利
権利情報 © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
キーワード
主題Scheme Other
主題 Transglutaminase
キーワード
主題Scheme Other
主題 Keratinocyte
キーワード
主題Scheme Other
主題 Epidermis
抄録
内容記述 Transglutaminase (TGase) catalyzes protein cross-linking reactions essential for several biological processes. In differentiating keratinocytes, TG1 (keratinocyte-type) is crucial for the cross-linking of substrate proteins required for the complete formation of the cornified envelop, a proteinaceous supermolecule located in the outermost layer of the epidermis. TG1 expressions and its substrate were induced in cultured keratinocytes at differentiation-stage specific manner. In the cultured keratinocytes, we used the TG1-specific substrate peptide, which enables the specific detection of enzymatic activity to investigate its induction patterns. As a further application of the substrate peptide, several substrate candidates of TG1 that may be essential for cornified envelope formation were identified and characterized.
内容記述タイプ Abstract
出版者
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
ISSN
収録物識別子タイプ ISSN
収録物識別子 0006-291X
書誌情報 Biochemical and Biophysical Research Communications

巻 478, 号 1, p. 343-348, 発行日 2016-09
著者版フラグ
値 author
URI
識別子 http://dx.doi.org/10.1016/j.bbrc.2016.07.051
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/25155
識別子タイプ HDL
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