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Analysis on transglutaminase 1 and its substrates using specific substrate peptide in cultured keratinocytes
http://hdl.handle.net/2237/25155
http://hdl.handle.net/2237/251558a04c0d8-cdbd-42ad-80de-4d4cf0f13f27
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
BBRC-S-16-06867_Redacted.pdf ファイル公開：2017/09/01 (1.3 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-12-07 | |||||
| タイトル | ||||||
| タイトル | Analysis on transglutaminase 1 and its substrates using specific substrate peptide in cultured keratinocytes | |||||
| 言語 | en | |||||
| 著者 |
Yamane, Miki
× Yamane, Miki× Sugimura, Kayoko× Kawasaki, Hiroko× Tatsukawa, Hideki× Hitomi, Kiyotaka |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Transglutaminase | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Keratinocyte | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Epidermis | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Transglutaminase (TGase) catalyzes protein cross-linking reactions essential for several biological processes. In differentiating keratinocytes, TG1 (keratinocyte-type) is crucial for the cross-linking of substrate proteins required for the complete formation of the cornified envelop, a proteinaceous supermolecule located in the outermost layer of the epidermis. TG1 expressions and its substrate were induced in cultured keratinocytes at differentiation-stage specific manner. In the cultured keratinocytes, we used the TG1-specific substrate peptide, which enables the specific detection of enzymatic activity to investigate its induction patterns. As a further application of the substrate peptide, several substrate candidates of TG1 that may be essential for cornified envelope formation were identified and characterized. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.bbrc.2016.07.051 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0006-291X | |||||
| 書誌情報 |
en : Biochemical and Biophysical Research Communications 巻 478, 号 1, p. 343-348, 発行日 2016-09 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
| URI | ||||||
| 識別子 | http://dx.doi.org/10.1016/j.bbrc.2016.07.051 | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/25155 | |||||
| 識別子タイプ | HDL | |||||
