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Multifaceted Therapeutic Benefits of Factors Derived From Dental Pulp Stem Cells for Mouse Liver Fibrosis
http://hdl.handle.net/2237/25222
http://hdl.handle.net/2237/252229a9678f7-5e63-4d33-918b-f70773bafa86
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
hirata.pdf ファイル公開：2017/04/01 (3.2 MB)
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2016-12-16 | |||||
| タイトル | ||||||
| タイトル | Multifaceted Therapeutic Benefits of Factors Derived From Dental Pulp Stem Cells for Mouse Liver Fibrosis | |||||
| 言語 | en | |||||
| 著者 |
Hirata, Marina
× Hirata, Marina× Ishigami, Masatoshi× Matsushita, Yoshihiro× Ito, Takanori× Hattori, Hisashi× Hibi, Hideharu× Goto, Hidemi× Ueda, Minoru× Yamamoto, Akihito |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 権利情報 | ©AlphaMed Press. Marina Hirata, Masatoshi Ishigami, Yoshihiro Matsushita, Takanori Ito, Hisashi Hattori, Hideharu Hibi, Hidemi Goto, Minoru Ueda, Akihito Yamamoto; "Multifaceted Therapeutic Benefits of Factors Derived From Dental Pulp Stem Cells for Mouse Liver Fibrosis" Stem Cells Trans Med 2016; 5:1416-1424; first published on June 8, 2016; doi:10.5966/sctm.2015-0353 | |||||
| 言語 | en | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Chronic liver injury from various causes often results in liver fibrosis (LF). Although the liver possesses endogenous tissue-repairing activities, these can be overcome by sustained inflammation and excessive fibrotic scar formation. Advanced LF leads to irreversible cirrhosis and subsequent liver failure and/or hepatic cancer. Here, using the mouse carbon tetrachloride (CCl4)-induced LF model, we showed that a single intravenous administration of stem cells derived from human exfoliated deciduous teeth (SHEDs) or of SHED-derived serum-free conditioned medium (SHED-CM) resulted in fibrotic scar resolution. SHED-CM suppressed the gene expression of proinflammatory mediators, such as TNF-α, IL-1β, and iNOS, and eliminated activated hepatic stellate cells by inducing their apoptosis, but protected parenchymal hepatocytes from undergoing apoptosis. In addition, SHED-CM induced tissue-repairing macrophages that expressed high levels of the profibrinolytic factor, matrix metalloproteinase 13. Furthermore, SHED-CM suppressed the CCl4-induced apoptosis of primary cultured hepatocytes. SHED-CM contained a high level of hepatocyte growth factor (HGF). Notably, HGF-depleted SHED-CM (dHGF-CM) did not suppress the proinflammatory response or resolve fibrotic scarring. Furthermore, SHED-CM, but not dHGF-CM, inhibited CCl4-induced hepatocyte apoptosis. These results suggest that HGF plays a central role in the SHED-CM-mediated resolution of LF. Taken together, our findings suggest that SHED-CM provides multifaceted therapeutic benefits for the treatment of LF. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | AlphaMed Press | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.5966/sctm.2015-0353 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 2157-6564 | |||||
| 書誌情報 |
en : Stem Cells Translational Medicine 巻 5, 号 10, p. 1416-1424, 発行日 2016-10 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
| URI | ||||||
| 識別子 | http://doi.org/10.5966/sctm.2015-0353 | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/25222 | |||||
| 識別子タイプ | HDL | |||||
