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Roles of regulatory T cells in cancer immunity
http://hdl.handle.net/2237/25320
http://hdl.handle.net/2237/2532043abe488-2a8b-473c-9344-978055ab1b1d
名前 / ファイル | ライセンス | アクション |
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s1-ln234847841682381206-1939656818Hwf-2035235115IdV16389160123484784PDF_HI0001.pdf ファイル公開:2017/08/01 (1.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-01-05 | |||||
タイトル | ||||||
タイトル | Roles of regulatory T cells in cancer immunity | |||||
言語 | en | |||||
著者 |
Takeuchi, Yoshiko
× Takeuchi, Yoshiko× Nishikawa, Hiroyoshi |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | This is a pre-copyedited, author-produced version of an article accepted for publication in [International Immunology] following peer review. The version of record [International Immunology. v.28, n.8, 2016, p.401-409] is available online at: http://doi.org/10.1093/intimm/dxw025. | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | immune suppression | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | immune checkpoint inhibitors | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Treg-targeted therapy | |||||
抄録 | ||||||
内容記述 | CD4+ regulatory T cells (Tregs) expressing the transcription factor FoxP3 are highly immune suppressive and play central roles in the maintenance of self-tolerance and immune homeostasis, yet in malignant tumors they promote tumor progression by suppressing effective antitumor immunity. Indeed, higher infiltration by Tregs is observed in tumor tissues, and their depletion augments antitumor immune responses in animal models. Additionally, increased numbers of Tregs and, in particular, decreased ratios of CD8+ T cells to Tregs among tumor-infiltrating lymphocytes are correlated with poor prognosis in various types of human cancers. The recent success of cancer immunotherapy represented by immune checkpoint blockade has provided a new insight in cancer treatment, yet more than half of the treated patients did not experience clinical benefits. Identifying biomarkers that predict clinical responses and developing novel immunotherapies are therefore urgently required. Cancer patients whose tumors contain a large number of neoantigens stemming from gene mutations, which have not been previously recognized by the immune system, provoke strong antitumor T-cell responses associated with clinical responses following immune checkpoint blockade, depending on the resistance to Treg-mediated suppression. Thus, integration of a strategy restricting Treg-mediated immune suppression may expand the therapeutic spectrum of cancer immunotherapy towards patients with a lower number of neoantigens. In this review, we address the current understanding of Treg-mediated immune suppressive mechanisms in cancer, the involvement of Tregs in cancer immunotherapy, and strategies for effective and tolerable Treg-targeted therapy. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Oxford University Press | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1093/intimm/dxw025 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0953-8178 | |||||
書誌情報 |
en : International Immunology 巻 28, 号 8, p. 401-409, 発行日 2016-08 |
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著者版フラグ | ||||||
値 | author | |||||
URI | ||||||
識別子 | http://doi.org/10.1093/intimm/dxw025 | |||||
識別子タイプ | DOI | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/25320 | |||||
識別子タイプ | HDL |