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Identification of enzymes involved in the mevalonate pathway of Flavobacterium johnsoniae
http://hdl.handle.net/2237/26857
0206937c-296b-4e3b-a001-766fd4e6d4c9
名前 / ファイル | ライセンス | アクション | |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-08-01 | |||||
タイトル | ||||||
タイトル | Identification of enzymes involved in the mevalonate pathway of Flavobacterium johnsoniae | |||||
著者 |
Hayakawa, Hajime
× Hayakawa, Hajime× Sobue, Fumiaki× Motoyama, Kento× Yoshimura, Tohru× Hemmi, Hisashi |
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権利 | ||||||
権利情報 | © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mevalonate pathway | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | isoprenoid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | mevalonate kinase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | phosphomevalonate kinase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | diphosphomevalonate decarboxylase | |||||
抄録 | ||||||
内容記述 | The mevalonate pathway is prevalent in eukaryotes, archaea, and a limited number of bacteria. This pathway yields the fundamental precursors for isoprenoid biosynthesis, i.e., isopentenyl diphosphate and dimethylally diphosphate. In the downstream part of the general eukaryote-type mevalonate pathway,mevalonate is converted into isopentenyl diphosphate by the sequential actions of mevalonate kinase, phosphomevalonate kinase, and diphosphomevalonte decarboxylase, while a partial lack of the putative genes of these enzymes is sometimes observed in archaeal and bacterial genomes. The absence of these genes has led to the recent discovery of modified mevalonate pathways. Therefore, we decided to investigate the mevalonate pathway of Flavobacterium johnsoniae, a bacterium of the phylum Bacteroidetes,which is reported to lack the genes of mevalonate kinase and phosphomevalonate kinase. This study provides proof of the existence of the general mevalonate pathway in F. johnsoniae, although the pathway involves the kinases that are distantly related to the known enzymes. |
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内容記述タイプ | Abstract | |||||
出版者 | ||||||
出版者 | Elsevier | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0006-291X | |||||
書誌情報 |
Biochemical and Biophysical Research Communications 巻 487, 号 3, p. 702-708, 発行日 2017-06-03 |
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著者版フラグ | ||||||
値 | author | |||||
URI | ||||||
識別子 | https://doi.org/10.1016/j.bbrc.2017.04.120 | |||||
識別子タイプ | DOI | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/26857 | |||||
識別子タイプ | HDL |