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  1. B200 工学部/工学研究科
  2. B200a 雑誌掲載論文
  3. 学術雑誌

A Novel Apparatus for the Multifaceted Evaluation of Arterial Function Through Transmural Pressure Manipulation

http://hdl.handle.net/2237/26875
http://hdl.handle.net/2237/26875
b9e2415b-afb2-489a-8573-d4b644ba0bc7
名前 / ファイル ライセンス アクション
Paper49forRepository.pdf Paper49forRepository.pdf ファイル公開:2018/06/01 (8.5 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-08-03
タイトル
タイトル A Novel Apparatus for the Multifaceted Evaluation of Arterial Function Through Transmural Pressure Manipulation
言語 en
著者 Yaguchi, Toshiyuki

× Yaguchi, Toshiyuki

WEKO 73058

en Yaguchi, Toshiyuki

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Cong, Yalin

× Cong, Yalin

WEKO 73059

en Cong, Yalin

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Shimo, Kenji

× Shimo, Kenji

WEKO 73060

en Shimo, Kenji

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Kurokawa, Takahiro

× Kurokawa, Takahiro

WEKO 73061

en Kurokawa, Takahiro

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Sugita, Shukei

× Sugita, Shukei

WEKO 73062

en Sugita, Shukei

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Nagayama, Kazuaki

× Nagayama, Kazuaki

WEKO 73063

en Nagayama, Kazuaki

Search repository
Masuda, Hiroshi

× Masuda, Hiroshi

WEKO 73064

en Masuda, Hiroshi

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Matsumoto, Takeo

× Matsumoto, Takeo

WEKO 73065

en Matsumoto, Takeo

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 The final publication is available at Springer via https://doi.org/10.1007/s10439-017-1810-z
抄録
内容記述 A novel apparatus for the multifaceted evaluation of artery function was developed. It measures endothelial and smooth muscle functions and the pressure–strain elastic modulus (Ep). A rigid airtight chamber with an ultrasound probe was attached to the upper arm to manipulate the transmural pressure of the brachial artery. Endothelial function was measured via a standard flow-mediated dilation (FMD) protocol. Smooth muscle function was evaluated via a myogenic contraction of the artery following the application of negative pressure to the chamber and was named pressure-mediated contraction (PMC). Ep was obtained by measuring the instantaneous increase in the artery diameter following the negative pressure application. The PMC and FMD values had a significant negative correlation with age, indicating that the age-related decrease in FMD is caused by the decay of endothelial and smooth muscle function. A consideration of PMC may help improve the accuracy of artery function measurement. Ep in subjects aged >40 years was found to be significantly higher in the supra-physiological pressure range than in the physiological one (p = 0.02); this did not occur in younger subjects. Artery stiffening may begin in the supra-physiological range, and this stiffness may also be used for the diagnosis of atherosclerosis.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Springer
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s10439-017-1810-z
ISSN
収録物識別子タイプ PISSN
収録物識別子 0090-6964
書誌情報 en : Annals of Biomedical Engineering

巻 45, 号 6, p. 1487-1495, 発行日 2017-06
著者版フラグ
値 author
URI
識別子 https://doi.org/10.1007/s10439-017-1810-z
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/26875
識別子タイプ HDL
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