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A Novel Apparatus for the Multifaceted Evaluation of Arterial Function Through Transmural Pressure Manipulation
http://hdl.handle.net/2237/26875
http://hdl.handle.net/2237/26875b9e2415b-afb2-489a-8573-d4b644ba0bc7
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Paper49forRepository.pdf ファイル公開：2018/06/01 (8.5 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-08-03 | |||||
| タイトル | ||||||
| タイトル | A Novel Apparatus for the Multifaceted Evaluation of Arterial Function Through Transmural Pressure Manipulation | |||||
| 言語 | en | |||||
| 著者 |
Yaguchi, Toshiyuki
× Yaguchi, Toshiyuki× Cong, Yalin× Shimo, Kenji× Kurokawa, Takahiro× Sugita, Shukei× Nagayama, Kazuaki× Masuda, Hiroshi× Matsumoto, Takeo |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | The final publication is available at Springer via https://doi.org/10.1007/s10439-017-1810-z | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | A novel apparatus for the multifaceted evaluation of artery function was developed. It measures endothelial and smooth muscle functions and the pressure–strain elastic modulus (Ep). A rigid airtight chamber with an ultrasound probe was attached to the upper arm to manipulate the transmural pressure of the brachial artery. Endothelial function was measured via a standard flow-mediated dilation (FMD) protocol. Smooth muscle function was evaluated via a myogenic contraction of the artery following the application of negative pressure to the chamber and was named pressure-mediated contraction (PMC). Ep was obtained by measuring the instantaneous increase in the artery diameter following the negative pressure application. The PMC and FMD values had a significant negative correlation with age, indicating that the age-related decrease in FMD is caused by the decay of endothelial and smooth muscle function. A consideration of PMC may help improve the accuracy of artery function measurement. Ep in subjects aged >40 years was found to be significantly higher in the supra-physiological pressure range than in the physiological one (p = 0.02); this did not occur in younger subjects. Artery stiffening may begin in the supra-physiological range, and this stiffness may also be used for the diagnosis of atherosclerosis. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Springer | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1007/s10439-017-1810-z | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0090-6964 | |||||
| 書誌情報 |
en : Annals of Biomedical Engineering 巻 45, 号 6, p. 1487-1495, 発行日 2017-06 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
| URI | ||||||
| 識別子 | https://doi.org/10.1007/s10439-017-1810-z | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/26875 | |||||
| 識別子タイプ | HDL | |||||
