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Optimized treatment strategy of radiotherapy for early glottic squamous cell carcinomas : An initial analysis
https://doi.org/10.18999/nagjms.79.3.331
https://doi.org/10.18999/nagjms.79.3.3317956889f-3165-4039-8f93-3f2a11661dc2
名前 / ファイル | ライセンス | アクション |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2017-08-23 | |||||
タイトル | ||||||
タイトル | Optimized treatment strategy of radiotherapy for early glottic squamous cell carcinomas : An initial analysis | |||||
著者 |
Kimura, Kana
× Kimura, Kana× Itoh, Yoshiyuki× Okada, Tohru× Kubota, Seiji× Kawamura, Mariko× Nakahara, Rie× Oie, Yumi× Kozai, Yuka× Takase, Yuuki× Tsuzuki, Hidenori× Nishio, Naoki× Hiramatsu, Mariko× Fujimoto, Yasushi× Mizutani, Takefumi× Naganawa, Shinji |
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キーワード | ||||||
主題Scheme | Other | |||||
主題 | early glottic cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | radiotherapy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chemoradiotherapy | |||||
抄録 | ||||||
内容記述 | The purpose of this study was to evaluate the clinical outcomes of radiotherapy for patients with T1/T2 glottic carcinoma. Patients with T1/T2 glottic carcinoma histopathologically diagnosed with squamous cell carcinoma and treated at our hospital between 2007 and 2015 were analyzed retrospectively. Our strategy for T1/T2 glottic carcinoma was as follows: radiotherapy alone with 2.25 Gy per fraction to a total of 25–28 fractions for patients with non-bulky T1 glottic carcinoma; concurrent chemoradiotherapy with oral S-1 and radiotherapy with 2 Gy per fraction to a total of 30 fractions for patients with T1 bulky/T2 favorable glottic carcinoma; or chemoradiotherapy with high-dose cisplatin and radiotherapy with 2 Gy per fraction to a total of 35 fractions for T2 unfavorable glottic carcinoma. Forty-eight patients were eligible. The median follow-up period among surviving patients was 38 months (range, 11–107). The disease was T1a in 23%, T1b in 13%, and T2 in 65% of patients. The 3-year local control rate in all patients, T1a, T1b, and T2 was 96.7%, 100%, 100%, and 96.0%, respectively. Of the 46 patients, one with T2 glottic carcinoma developed recurrent disease at the primary site, and one with T2 glottic carcinoma had lymph node recurrences in the neck. Acute Grade 3 dermatitis occurred in 8 (17%) patients and late Grade 2 hypothyroidism occurred in 2 (4%) patients. This retrospective study shows that our optimized treatment strategy of radiotherapy depending on the stage of early glottic carcinoma is not only effective but also well-tolerated. | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
出版者 | Nagoya University Graduate School of Medicine, School of Medicine | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.79.3.331 | |||||
ID登録タイプ | JaLC | |||||
ISSN(print) | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0027-7622 | |||||
書誌情報 |
Nagoya Journal of Medical Science 巻 79, 号 3, p. 331-338, 発行日 2017-08 |
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著者版フラグ | ||||||
値 | publisher | |||||
URI | ||||||
識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/793.html | |||||
識別子タイプ | URI | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/26911 | |||||
識別子タイプ | HDL |