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Sulfur restriction extends fission yeast chronological lifespan through Ecl1 family genes by downregulation of ribosome
http://hdl.handle.net/2237/26998
http://hdl.handle.net/2237/26998ae14cccc-1071-4422-b697-a49cac732c52
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Total.pdf ファイル公開:2018/07/01 (8.0 MB)
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-05 | |||||
| タイトル | ||||||
| タイトル | Sulfur restriction extends fission yeast chronological lifespan through Ecl1 family genes by downregulation of ribosome | |||||
| 言語 | en | |||||
| 著者 |
Ohtsuka, Hokuto
× Ohtsuka, Hokuto× Takinami, Masahiro× Shimasaki, Takafumi× Hibi, Takahide× Murakami, Hiroshi× Aiba, Hirofumi |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 権利情報 | This is the peer reviewed version of the following article: [H.Ohtsuka, M.Takinami, T.Shimasaki,T.Hibi,H.Murakami,and H.Aiba,Molecular Microbiology.v.105,n.1, 2017,p.84-97]which has been published in final form at [http://doi.org/10.1111/mmi.13686]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | |||||
| 言語 | en | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Nutritional restrictions such as calorie restrictions are known to increase the lifespan of various organisms. Here, we found that a restriction of sulfur extended the chronological lifespan (CLS) of the fission yeast Schizosaccharomyces pombe. The restriction decreased cellular size, RNA content, and ribosomal proteins and increased sporulation rate. These responses depended on Ecl1 family genes, the overexpression of which results in the extension of CLS. We also showed that the Zip1 transcription factor results in the sulfur restriction-dependent expression of the ecl1^+ gene. We demonstrated that a decrease in ribosomal activity results in the extension of CLS. Based on these observations, we propose that sulfur restriction extends CLS through Ecl1 family genes in a ribosomal activity-dependent manner. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Wiley | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1111/mmi.13686 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0950-382X | |||||
| 書誌情報 |
en : Molecular Microbiology 巻 105, 号 1, p. 84-97, 発行日 2017-07 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
| URI | ||||||
| 識別子 | http://doi.org/10.1111/mmi.13686 | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/26998 | |||||
| 識別子タイプ | HDL | |||||
