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Few animal models of nephropathy related to malarial infection have been reported. Therefore, we developed and investigated a novel malarial nephropathy\nmodel in mice infected by murine malaria parasites.\u3000Methods NC mice and C57BL/6J mice were infected with Ttwo different murine malaria parasites, Plasmodium (P.)chabaudi AS and P. yoelii 17X. After the infection, renal\npathology and blood and urinary biochemistry were analyzed.Results NC mice infected by the murine malaria parasite P. chabaudi AS, but not P. yoelii 17X, developed mesangial proliferative glomerulonephritis with endothelial damage, and decreased serum albumin concentration and\u3000increased\u3000proteinuria. These pathological changes were\naccompanied by deposition of immunoglobulin G and\u3000complement component 3, mainly in the mesangium until\u3000day 4 and in the mesangium and glomerular capillaries from day 8. On day 21, renal pathology developed to focal\nsegmental sclerosis according to light\u3000microscopy. In\u3000C57BL/6J mice, renal injuries were not observed from\neither parasite infection.\nConclusion The clinical and pathological features of P.chabaudi AS infection in NC mice might be similar to\u3000quartan malarial nephropathy resulting from human\u3000malaria parasite P. malariae infection. 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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Mesangial proliferative glomerulonephritis in murine malaria parasite, Plasmodium chabaudi AS, infected NC mice

http://hdl.handle.net/2237/27030
2ef6b5f7-0d61-4374-be95-cbc540150673
名前 / ファイル ライセンス アクション
R2_revised_Fig_set.pdf R2_revised_Fig_set.pdf ファイル公開:2018/08/01 (1.4 MB)
clean_Ver_R2_revised_ver_1605549-R2.pdf clean_Ver_R2_revised_ver_1605549-R2.pdf ファイル公開: 2018/08/01 (304.7 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-10-12
タイトル
タイトル Mesangial proliferative glomerulonephritis in murine malaria parasite, Plasmodium chabaudi AS, infected NC mice
著者 Yashima, Akihito

× Yashima, Akihito

WEKO 73787

Yashima, Akihito

Search repository
Mizuno, Masashi

× Mizuno, Masashi

WEKO 73788

Mizuno, Masashi

Search repository
Yuzawa, Yukio

× Yuzawa, Yukio

WEKO 73789

Yuzawa, Yukio

Search repository
Shimada, Koki

× Shimada, Koki

WEKO 73790

Shimada, Koki

Search repository
Suzuki, Norihiko

× Suzuki, Norihiko

WEKO 73791

Suzuki, Norihiko

Search repository
Tawada, Hideo

× Tawada, Hideo

WEKO 73792

Tawada, Hideo

Search repository
Sato, Waichi

× Sato, Waichi

WEKO 73793

Sato, Waichi

Search repository
Tsuboi, Naotake

× Tsuboi, Naotake

WEKO 73794

Tsuboi, Naotake

Search repository
Maruyama, Shoichi

× Maruyama, Shoichi

WEKO 73795

Maruyama, Shoichi

Search repository
Ito, Yasuhiko

× Ito, Yasuhiko

WEKO 73796

Ito, Yasuhiko

Search repository
Matsuo, Seiichi

× Matsuo, Seiichi

WEKO 73797

Matsuo, Seiichi

Search repository
Ohno, Tamio

× Ohno, Tamio

WEKO 73798

Ohno, Tamio

Search repository
権利
権利情報 The final publication is available at Springer via http://doi.org/10.1007/s10157-016-1339-8
キーワード
主題Scheme Other
主題 Animal model
キーワード
主題Scheme Other
主題 Glomerulonephritis
キーワード
主題Scheme Other
主題 Malarial nephropathy
キーワード
主題Scheme Other
主題 NC mice
キーワード
主題Scheme Other
主題 Nephrotic syndrome
抄録
内容記述 Background Malaria is an important tropical disease and has remained a serious health problem in many countries.
One of the critical complications of malarial infection is renal injury, such as acute renal failure and chronic glomerulopathy. Few animal models of nephropathy related to malarial infection have been reported. Therefore, we developed and investigated a novel malarial nephropathy
model in mice infected by murine malaria parasites. Methods NC mice and C57BL/6J mice were infected with Ttwo different murine malaria parasites, Plasmodium (P.)chabaudi AS and P. yoelii 17X. After the infection, renal
pathology and blood and urinary biochemistry were analyzed.Results NC mice infected by the murine malaria parasite P. chabaudi AS, but not P. yoelii 17X, developed mesangial proliferative glomerulonephritis with endothelial damage, and decreased serum albumin concentration and increased proteinuria. These pathological changes were
accompanied by deposition of immunoglobulin G and complement component 3, mainly in the mesangium until day 4 and in the mesangium and glomerular capillaries from day 8. On day 21, renal pathology developed to focal
segmental sclerosis according to light microscopy. In C57BL/6J mice, renal injuries were not observed from
either parasite infection.
Conclusion The clinical and pathological features of P.chabaudi AS infection in NC mice might be similar to quartan malarial nephropathy resulting from human malaria parasite P. malariae infection. The NC mouse
model might therefore be useful in analyzing the underlying mechanisms and developing therapeutic approaches to malaria-related nephropathy.
内容記述タイプ Abstract
出版者
出版者 Springer
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
ISSN
収録物識別子タイプ ISSN
収録物識別子 1342-1751
書誌情報 Clinical and Experimental Nephrology

巻 21, 号 4, p. 589-596, 発行日 2017-08
著者版フラグ
値 author
URI
識別子 http://doi.org/10.1007/s10157-016-1339-8
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/27030
識別子タイプ HDL
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