{"_buckets": {"deposit": "fd568936-fcbc-4952-b6bd-03980f054fef"}, "_deposit": {"id": "24809", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "24809"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00024809"}, "item_10_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-08", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "596", "bibliographicPageStart": "589", "bibliographicVolumeNumber": "21", "bibliographic_titles": [{"bibliographic_title": "Clinical and Experimental Nephrology"}]}]}, "item_10_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Background Malaria is an important tropical disease and has remained a serious health problem in many countries.\nOne of the critical complications of malarial infection is renal injury, such as acute renal failure and chronic glomerulopathy. Few animal models of nephropathy related to malarial infection have been reported. Therefore, we developed and investigated a novel malarial nephropathy\nmodel in mice infected by murine malaria parasites.\u3000Methods NC mice and C57BL/6J mice were infected with Ttwo different murine malaria parasites, Plasmodium (P.)chabaudi AS and P. yoelii 17X. After the infection, renal\npathology and blood and urinary biochemistry were analyzed.Results NC mice infected by the murine malaria parasite P. chabaudi AS, but not P. yoelii 17X, developed mesangial proliferative glomerulonephritis with endothelial damage, and decreased serum albumin concentration and\u3000increased\u3000proteinuria. These pathological changes were\naccompanied by deposition of immunoglobulin G and\u3000complement component 3, mainly in the mesangium until\u3000day 4 and in the mesangium and glomerular capillaries from day 8. On day 21, renal pathology developed to focal\nsegmental sclerosis according to light\u3000microscopy. In\u3000C57BL/6J mice, renal injuries were not observed from\neither parasite infection.\nConclusion The clinical and pathological features of P.chabaudi AS infection in NC mice might be similar to\u3000quartan malarial nephropathy resulting from human\u3000malaria parasite P. malariae infection. The NC mouse\nmodel might therefore be useful in analyzing the underlying\u3000mechanisms and developing therapeutic approaches to\u3000malaria-related nephropathy.", "subitem_description_type": "Abstract"}]}, "item_10_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "DOI", "subitem_identifier_uri": "http://doi.org/10.1007/s10157-016-1339-8"}, {"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/27030"}]}, "item_10_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Springer"}]}, "item_10_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "The final publication is available at Springer via http://doi.org/10.1007/s10157-016-1339-8"}]}, "item_10_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1342-1751", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yashima, Akihito"}], "nameIdentifiers": [{"nameIdentifier": "73787", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mizuno, Masashi"}], "nameIdentifiers": [{"nameIdentifier": "73788", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yuzawa, Yukio"}], "nameIdentifiers": [{"nameIdentifier": "73789", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimada, Koki"}], "nameIdentifiers": [{"nameIdentifier": "73790", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Norihiko"}], "nameIdentifiers": [{"nameIdentifier": "73791", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tawada, Hideo"}], "nameIdentifiers": [{"nameIdentifier": "73792", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sato, Waichi"}], "nameIdentifiers": [{"nameIdentifier": "73793", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tsuboi, Naotake"}], "nameIdentifiers": [{"nameIdentifier": "73794", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Maruyama, Shoichi"}], "nameIdentifiers": [{"nameIdentifier": "73795", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ito, Yasuhiko"}], "nameIdentifiers": [{"nameIdentifier": "73796", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuo, Seiichi"}], "nameIdentifiers": [{"nameIdentifier": "73797", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ohno, Tamio"}], "nameIdentifiers": [{"nameIdentifier": "73798", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", 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"licensetype": "license_free", "mimetype": "application/pdf", "size": 304700.0, "url": {"label": "clean_Ver_R2_revised_ver_1605549-R2.pdf \u30d5\u30a1\u30a4\u30eb\u516c\u958b: 2018/08/01", "url": "https://nagoya.repo.nii.ac.jp/record/24809/files/clean_Ver_R2_revised_ver_1605549-R2.pdf"}, "version_id": "cd12296f-0e62-47bc-9f87-4899a0456c22"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Animal model", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Glomerulonephritis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Malarial nephropathy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "NC mice", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Nephrotic syndrome", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", 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