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Mesangial proliferative glomerulonephritis in murine malaria parasite, Plasmodium chabaudi AS, infected NC mice
http://hdl.handle.net/2237/27030
http://hdl.handle.net/2237/270302ef6b5f7-0d61-4374-be95-cbc540150673
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R2_revised_Fig_set.pdf ファイル公開:2018/08/01 (1.4 MB)
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clean_Ver_R2_revised_ver_1605549-R2.pdf ファイル公開: 2018/08/01 (304.7 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-12 | |||||
| タイトル | ||||||
| タイトル | Mesangial proliferative glomerulonephritis in murine malaria parasite, Plasmodium chabaudi AS, infected NC mice | |||||
| 言語 | en | |||||
| 著者 |
Yashima, Akihito
× Yashima, Akihito× Mizuno, Masashi× Yuzawa, Yukio× Shimada, Koki× Suzuki, Norihiko× Tawada, Hideo× Sato, Waichi× Tsuboi, Naotake× Maruyama, Shoichi× Ito, Yasuhiko× Matsuo, Seiichi× Ohno, Tamio |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | The final publication is available at Springer via http://doi.org/10.1007/s10157-016-1339-8 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Animal model | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Glomerulonephritis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Malarial nephropathy | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | NC mice | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Nephrotic syndrome | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background Malaria is an important tropical disease and has remained a serious health problem in many countries. One of the critical complications of malarial infection is renal injury, such as acute renal failure and chronic glomerulopathy. Few animal models of nephropathy related to malarial infection have been reported. Therefore, we developed and investigated a novel malarial nephropathy model in mice infected by murine malaria parasites. Methods NC mice and C57BL/6J mice were infected with Ttwo different murine malaria parasites, Plasmodium (P.)chabaudi AS and P. yoelii 17X. After the infection, renal pathology and blood and urinary biochemistry were analyzed.Results NC mice infected by the murine malaria parasite P. chabaudi AS, but not P. yoelii 17X, developed mesangial proliferative glomerulonephritis with endothelial damage, and decreased serum albumin concentration and increased proteinuria. These pathological changes were accompanied by deposition of immunoglobulin G and complement component 3, mainly in the mesangium until day 4 and in the mesangium and glomerular capillaries from day 8. On day 21, renal pathology developed to focal segmental sclerosis according to light microscopy. In C57BL/6J mice, renal injuries were not observed from either parasite infection. Conclusion The clinical and pathological features of P.chabaudi AS infection in NC mice might be similar to quartan malarial nephropathy resulting from human malaria parasite P. malariae infection. The NC mouse model might therefore be useful in analyzing the underlying mechanisms and developing therapeutic approaches to malaria-related nephropathy. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Springer | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1007/s10157-016-1339-8 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 1342-1751 | |||||
| 書誌情報 |
en : Clinical and Experimental Nephrology 巻 21, 号 4, p. 589-596, 発行日 2017-08 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
| URI | ||||||
| 識別子 | http://doi.org/10.1007/s10157-016-1339-8 | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/27030 | |||||
| 識別子タイプ | HDL | |||||
