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Transcription dynamics stabilizes nucleus-like layer structure in chromatin brush
http://hdl.handle.net/2237/27085
http://hdl.handle.net/2237/2708556e0566b-ca16-41f0-a4e4-cda49b32131d
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TetsuyaHelmutSoftMatter20160902ver16SIfinal.pdf ファイル公開：2018/08/21 (250.4 kB)
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TetsuyaHelmutSoftMatter20160902ver16final.pdf ファイル公開：2018/08/21 (734.9 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-08-21 | |||||
| タイトル | ||||||
| タイトル | Transcription dynamics stabilizes nucleus-like layer structure in chromatin brush | |||||
| 言語 | en | |||||
| 著者 |
Tetsuya, Yamamoto
× Tetsuya, Yamamoto× Helmut, Schiessel |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We use a brush of DNA in a solution of transcriptional machinery and histone proteins to theoretically predict that this brush shows phase separation due to the instability arising from the disassembly of nucleosomes during transcription. In the two-phase coexistent state, collapsed chains (with relatively large nucleosome occupancy) lie at the grafting surface and swollen chains (with relatively small nucleosome occupancy) are distributed at the space above the collapsed chains, analogous to the structure of chromatin in differentiated cells. This layer structure is stabilized by the lateral osmotic pressure of swollen chains. For a relatively small grafting density, DNA brushes show tricritical points because the entropic elasticity with respect to the lateral excursion of swollen chains balances with the lateral osmotic pressure of these chains. At the tricritical points, DNA brushes show large fluctuations of local nucleosome concentration, which may be reminiscent of the fluctuations observed in embryonic stem cells. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Royal Society of Chemistry | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1039/c7sm00239d | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 1744-683X | |||||
| 書誌情報 |
en : Soft Matter 巻 13, 号 31, p. 5307-5316, 発行日 2017-08-21 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
| URI | ||||||
| 識別子 | http://doi.org/10.1039/c7sm00239d | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/27085 | |||||
| 識別子タイプ | HDL | |||||
