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  1. B200 工学部/工学研究科
  2. B200a 雑誌掲載論文
  3. 学術雑誌

Transcription dynamics stabilizes nucleus-like layer structure in chromatin brush

http://hdl.handle.net/2237/27085
56e0566b-ca16-41f0-a4e4-cda49b32131d
名前 / ファイル ライセンス アクション
TetsuyaHelmutSoftMatter20160902ver16SIfinal.pdf TetsuyaHelmutSoftMatter20160902ver16SIfinal.pdf ファイル公開:2018/08/21 (250.4 kB)
TetsuyaHelmutSoftMatter20160902ver16final.pdf TetsuyaHelmutSoftMatter20160902ver16final.pdf ファイル公開:2018/08/21 (734.9 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2017-08-21
タイトル
タイトル Transcription dynamics stabilizes nucleus-like layer structure in chromatin brush
著者 Tetsuya, Yamamoto

× Tetsuya, Yamamoto

WEKO 73968

Tetsuya, Yamamoto

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Helmut, Schiessel

× Helmut, Schiessel

WEKO 73969

Helmut, Schiessel

Search repository
抄録
内容記述 We use a brush of DNA in a solution of transcriptional machinery and histone proteins to theoretically predict that this brush shows phase separation due to the instability arising from the disassembly of nucleosomes during transcription. In the two-phase coexistent state, collapsed chains (with relatively large nucleosome occupancy) lie at the grafting surface and swollen chains (with relatively small nucleosome occupancy) are distributed at the space above the collapsed chains, analogous to the structure of chromatin in differentiated cells. This layer structure is stabilized by the lateral osmotic pressure of swollen chains. For a relatively small grafting density, DNA brushes show tricritical points because the entropic elasticity with respect to the lateral excursion of swollen chains balances with the lateral osmotic pressure of these chains. At the tricritical points, DNA brushes show large fluctuations of local nucleosome concentration, which may be reminiscent of the fluctuations observed in embryonic stem cells.
内容記述タイプ Abstract
出版者
出版者 Royal Society of Chemistry
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
ISSN
収録物識別子タイプ ISSN
収録物識別子 1744-683X
書誌情報 Soft Matter

巻 13, 号 31, p. 5307-5316, 発行日 2017-08-21
著者版フラグ
値 author
URI
識別子 http://doi.org/10.1039/c7sm00239d
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/27085
識別子タイプ HDL
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