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GvHD prophylaxis after single-unit reduced intensity conditioning cord blood transplantation in adults with acute leukemia
http://hdl.handle.net/2237/27153
http://hdl.handle.net/2237/271536632e23a-c028-42ab-a10e-842ff1150a5a
名前 / ファイル | ライセンス | アクション |
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18558_1_merged_1491317774.pdf ファイル公開日:2017/12/12 (608.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-12-07 | |||||
タイトル | ||||||
タイトル | GvHD prophylaxis after single-unit reduced intensity conditioning cord blood transplantation in adults with acute leukemia | |||||
言語 | en | |||||
著者 |
Terakura, Seitaro
× Terakura, Seitaro× Kuwatsuka, Yachiyo× Yamasaki, Satoshi× Wake, Atsushi× Kanda, Junya× Inamoto, Yoshihiro× Mizuta, Shuichi× Yamaguchi, Takuhiro× Uchida, Naoyuki× Kouzai, Yasuji× Aotsuka, Nobuyuki× Ogawa, Hiroyasu× Kanamori, Heiwa× Nishiwaki, Kaichi× Miyakoshi, Shigesaburo× Onizuka, Makoto× Amano, Itsuto× Fukuda, Takahiro× Ichinohe, Tatsuo× Atsuta, Yoshiko× Murata, Makoto× Teshima, Takanori |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Graft-versus-host disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | GVHD prophylaxis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | immunosuppressant selection | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | reduced intensity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | single-unit umbilical cord blood transplantation | |||||
抄録 | ||||||
内容記述 | To investigate better GVHD prophylaxis in reduced intensity conditioning umbilical cord blood transplantation (RIC-UCBT), we compared transplant outcomes after UCBT among GvHD prophylaxes using the registry data. We selected patients transplanted for AML or ALL with a calcineurin inhibitor and methotrexate (MTX)/mycophenolate mofetil (MMF) combination. A total of 748 first RIC-UCBT between 2000 and 2012 (MTX+ group, 446, MMF+ group, 302) were included. The cumulative incidence of neutrophil and platelet counts higher than 50 000/μL was significantly better in the MMF+ group (relative risk (RR), 1.55; P<0.001: RR, 1.34; P=0.003, respectively). In multivariate analyses, the risk of grade II–IV and III–IV acute GvHD was significantly higher in the MMF+ group than in the MTX+ group (RR, 1.75; P<0.001: RR, 1.97; P=0.004, respectively). In disease-specific analyses of AML, the risk of relapse of high-risk disease was significantly lower in the MMF+ group (RR, 0.69; P=0.009), whereas no significant difference was observed in the risk of relapse-free and overall survival in high-risk disease. In patients with standard-risk disease, no significant differences were noted in the risk of relapse or survival between the MTX+ and MMF+ groups. Collectively, these results suggest that MMF-containing prophylaxis may be preferable in RIC-UCBT, particularly for high-risk disease. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | nature | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1038/bmt.2017.116 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0268-3369 | |||||
書誌情報 |
en : BONE MARROW TRANSPLANTATION 巻 52, 号 9, p. 1261-1267, 発行日 2017-06-12 |
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著者版フラグ | ||||||
値 | author | |||||
URI | ||||||
識別子 | http://doi.org/10.1038/bmt.2017.116 | |||||
識別子タイプ | DOI | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2237/27153 | |||||
識別子タイプ | HDL |