{"_buckets": {"deposit": "3e4bb10b-7f82-470b-8ca3-7720ba2581ff"}, "_deposit": {"id": "25091", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "25091"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00025091"}, "item_10_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "11", "bibliographicPageEnd": "574", "bibliographicPageStart": "564", "bibliographicVolumeNumber": "67", "bibliographic_titles": [{"bibliographic_title": "PATHOLOGY INTERNATIONAL"}]}]}, "item_10_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Oxidative stress including iron excess has been associated with carcinogenesis. The level of 8-oxoguanine, a major oxidatively modified base in DNA, is maintained very low by three distinct enzymes, encoded by OGG1, MUTYH and MTH1. Germline biallelic inactivation of MUTYH represents a familial cancer syndrome called MUTYH-associated polyposis. Here, we used Mutyh-deficient mice to evaluate renal carcinogenesis induced by ferric nitrilotriacetate (Fe-NTA). Although the C57BL/6 background is cancer-resistant, a repeated intraperitoneal administration of Fe-NTA induced a high incidence of renal cell carcinoma (RCC; 26.7%) in Mutyh-deficient mice in comparison to wild-type mice (7.1%). Fe-NTA treatment also induced renal malignant lymphoma, which did not occur without the Fe-NTA treatment in both the genotypes. Renal tumor-free survival after Fe-NTA treatment was marginally different (P\u2009=\u20090.157) between the two genotypes. Array-based comparative genome hybridization analyses revealed, in RCC, the loss of heterozygosity in chromosomes 4 and 12 without p16INK[4]A inactivation; these results were confirmed by a methylation analysis and showed no significant difference between the genotypes. Lymphomas showed a preference for genomic amplifications. Dlk1 inactivation by promoter methylation may be involved in carcinogenesis in both tumors. Fe-NTA-induced murine RCCs revealed significantly less genomic aberrations than those in rats, demonstrating a marked species difference.", "subitem_description_type": "Abstract"}]}, "item_10_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "DOI", "subitem_identifier_uri": "http://doi.org/10.1111/pin.12598"}, {"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/27310"}]}, "item_10_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Wiley"}]}, "item_10_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "This is the peer reviewed version of the following article: [Li, G. H., Akatsuka, S., Chew, S. H., Jiang, L., Nishiyama, T., Sakamoto, A., Takahashi, T., Futakuchi, M., Suzuki, H., Sakumi, K., Nakabeppu, Y. and Toyokuni, S.(2017), Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model.PATHOLOGY INTERNATIONAL.,67: 564\u2013574. doi:10.1111/pin.12598], which has been published in final form at [http://doi.org/10.1111/pin.12598]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."}]}, "item_10_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1320-5463", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Li, Guang Hua"}], "nameIdentifiers": [{"nameIdentifier": "74823", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Akatsuka, Shinya"}], "nameIdentifiers": [{"nameIdentifier": "74824", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Chew, Shan Hwu"}], "nameIdentifiers": [{"nameIdentifier": "74825", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Jiang, Li"}], "nameIdentifiers": [{"nameIdentifier": "74826", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishiyama, Takahiro"}], "nameIdentifiers": [{"nameIdentifier": "74827", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sakamoto, Akihiko"}], "nameIdentifiers": [{"nameIdentifier": "74828", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahashi, Takashi"}], "nameIdentifiers": [{"nameIdentifier": "74829", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Futakuchi, Mitsuru"}], "nameIdentifiers": [{"nameIdentifier": "74830", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Hiromu"}], "nameIdentifiers": [{"nameIdentifier": "74831", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sakumi, Kunihiko"}], "nameIdentifiers": [{"nameIdentifier": "74832", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakabeppu, Yusaku"}], "nameIdentifiers": [{"nameIdentifier": "74833", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Toyokuni, Shinya"}], "nameIdentifiers": [{"nameIdentifier": "74834", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-11-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "deposit_1.pdf", "filesize": [{"value": "2.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2200000.0, "url": {"label": "deposit_1.pdf \u30d5\u30a1\u30a4\u30eb\u516c\u958b\u65e5:2018/11/01", "url": "https://nagoya.repo.nii.ac.jp/record/25091/files/deposit_1.pdf"}, "version_id": "131d57dc-2412-4d2a-b225-b801f451342b"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model"}]}, "item_type_id": "10", "owner": "1", "path": ["499/500/501"], "permalink_uri": "http://hdl.handle.net/2237/27310", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_name_i18n": "\u516c\u958b\u65e5", "attribute_value": "2018-01-30"}, "publish_date": "2018-01-30", "publish_status": "0", "recid": "25091", "relation": {}, "relation_version_is_last": true, "title": ["Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model"], "weko_shared_id": null}