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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model

http://hdl.handle.net/2237/27310
http://hdl.handle.net/2237/27310
a9622bf8-7214-4b93-8c07-4a6f7a2bf54c
名前 / ファイル ライセンス アクション
deposit_1.pdf deposit_1.pdf ファイル公開日:2018/11/01 (2.2 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-01-30
タイトル
タイトル Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model
言語 en
著者 Li, Guang Hua

× Li, Guang Hua

WEKO 74823

en Li, Guang Hua

Search repository
Akatsuka, Shinya

× Akatsuka, Shinya

WEKO 74824

en Akatsuka, Shinya

Search repository
Chew, Shan Hwu

× Chew, Shan Hwu

WEKO 74825

en Chew, Shan Hwu

Search repository
Jiang, Li

× Jiang, Li

WEKO 74826

en Jiang, Li

Search repository
Nishiyama, Takahiro

× Nishiyama, Takahiro

WEKO 74827

en Nishiyama, Takahiro

Search repository
Sakamoto, Akihiko

× Sakamoto, Akihiko

WEKO 74828

en Sakamoto, Akihiko

Search repository
Takahashi, Takashi

× Takahashi, Takashi

WEKO 74829

en Takahashi, Takashi

Search repository
Futakuchi, Mitsuru

× Futakuchi, Mitsuru

WEKO 74830

en Futakuchi, Mitsuru

Search repository
Suzuki, Hiromu

× Suzuki, Hiromu

WEKO 74831

en Suzuki, Hiromu

Search repository
Sakumi, Kunihiko

× Sakumi, Kunihiko

WEKO 74832

en Sakumi, Kunihiko

Search repository
Nakabeppu, Yusaku

× Nakabeppu, Yusaku

WEKO 74833

en Nakabeppu, Yusaku

Search repository
Toyokuni, Shinya

× Toyokuni, Shinya

WEKO 74834

en Toyokuni, Shinya

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is the peer reviewed version of the following article: [Li, G. H., Akatsuka, S., Chew, S. H., Jiang, L., Nishiyama, T., Sakamoto, A., Takahashi, T., Futakuchi, M., Suzuki, H., Sakumi, K., Nakabeppu, Y. and Toyokuni, S.(2017), Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model.PATHOLOGY INTERNATIONAL.,67: 564–574. doi:10.1111/pin.12598], which has been published in final form at [http://doi.org/10.1111/pin.12598]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
抄録
内容記述 Oxidative stress including iron excess has been associated with carcinogenesis. The level of 8-oxoguanine, a major oxidatively modified base in DNA, is maintained very low by three distinct enzymes, encoded by OGG1, MUTYH and MTH1. Germline biallelic inactivation of MUTYH represents a familial cancer syndrome called MUTYH-associated polyposis. Here, we used Mutyh-deficient mice to evaluate renal carcinogenesis induced by ferric nitrilotriacetate (Fe-NTA). Although the C57BL/6 background is cancer-resistant, a repeated intraperitoneal administration of Fe-NTA induced a high incidence of renal cell carcinoma (RCC; 26.7%) in Mutyh-deficient mice in comparison to wild-type mice (7.1%). Fe-NTA treatment also induced renal malignant lymphoma, which did not occur without the Fe-NTA treatment in both the genotypes. Renal tumor-free survival after Fe-NTA treatment was marginally different (P = 0.157) between the two genotypes. Array-based comparative genome hybridization analyses revealed, in RCC, the loss of heterozygosity in chromosomes 4 and 12 without p16INK[4]A inactivation; these results were confirmed by a methylation analysis and showed no significant difference between the genotypes. Lymphomas showed a preference for genomic amplifications. Dlk1 inactivation by promoter methylation may be involved in carcinogenesis in both tumors. Fe-NTA-induced murine RCCs revealed significantly less genomic aberrations than those in rats, demonstrating a marked species difference.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Wiley
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/pin.12598
ISSN
収録物識別子タイプ PISSN
収録物識別子 1320-5463
書誌情報 en : PATHOLOGY INTERNATIONAL

巻 67, 号 11, p. 564-574, 発行日 2017-11
著者版フラグ
値 author
URI
識別子 http://doi.org/10.1111/pin.12598
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/27310
識別子タイプ HDL
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