{"_buckets": {"deposit": "bc542424-7439-4bbe-a479-fec39732d401"}, "_deposit": {"id": "25137", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "25137"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00025137"}, "item_10_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-09-29", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "9062", "bibliographicPageStart": "9058", "bibliographicVolumeNumber": "2", "bibliographic_titles": [{"bibliographic_title": "ChemistrySelect"}]}]}, "item_10_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Inhibition self-assembly of \u03b2-amyloid (A\u03b2) is considered to be a strategy that can be potentially useful to develop treatment for Alzheimer\u0027s disease (AD). We have discovered that a protein unit that is found in the fimbriae of Gram-negative bacteria, which has a vacant site for a \u03b2-sheet strand, prevents A\u03b2 oligomerization effectively. Moreover, we found that a soluble but denatured form of this protein shows even higher potency. Our results also demonstrate the applicability of denatured proteins as pharmaceutical material.", "subitem_description_type": "Abstract"}]}, "item_10_identifier_60": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "DOI", "subitem_identifier_uri": "http://doi.org/10.1002/slct.201700658"}, {"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2237/27357"}]}, "item_10_publisher_32": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "Wiley"}]}, "item_10_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "This is the peer reviewed version of the following article: [K. Yamamoto, M. Oyaizu, T. Takahashi, Y. Watanabe, O. Shoji.(2017), Inhibiting Aggregation of \u03b2-Amyloid by Folded and Unfolded Forms of Fimbrial Protein of Gram-Negative Bacteria.\u3000ChemistrySelect,2:9058\u20139062. doi:10.1002/slct.201700658], which has been published in final form at [http://doi.org/10.1002/slct.201700658]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."}]}, "item_10_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2365-6549", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yamamoto, Keisuke"}], "nameIdentifiers": [{"nameIdentifier": "75012", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Oyaizu, Misa"}], "nameIdentifiers": [{"nameIdentifier": "75013", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahashi, Tsuyoshi"}], "nameIdentifiers": [{"nameIdentifier": "75014", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Watanabe, Yoshihito"}], "nameIdentifiers": [{"nameIdentifier": "75015", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shoji, Osami"}], "nameIdentifiers": [{"nameIdentifier": "75016", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-09-29"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "manuscript_slct_201700658R2.pdf", "filesize": [{"value": "1.6 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1600000.0, "url": {"label": "manuscript_slct_201700658R2.pdf \u30d5\u30a1\u30a4\u30eb\u516c\u958b\u65e5:2018/09/29", "url": "https://nagoya.repo.nii.ac.jp/record/25137/files/manuscript_slct_201700658R2.pdf"}, "version_id": "0aad957f-430a-4c2b-87fb-184d9c89160f"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Inhibiting Aggregation of \u03b2-Amyloid by Folded and Unfolded Forms of Fimbrial Protein of Gram-Negative Bacteria", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Inhibiting Aggregation of \u03b2-Amyloid by Folded and Unfolded Forms of Fimbrial Protein of Gram-Negative Bacteria"}]}, "item_type_id": "10", "owner": "1", "path": ["336/695/696"], "permalink_uri": "http://hdl.handle.net/2237/27357", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2018-02-05"}, "publish_date": "2018-02-05", "publish_status": "0", "recid": "25137", "relation": {}, "relation_version_is_last": true, "title": ["Inhibiting Aggregation of \u03b2-Amyloid by Folded and Unfolded Forms of Fimbrial Protein of Gram-Negative Bacteria"], "weko_shared_id": null}