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  1. B100 理学部/理学研究科
  2. B100a 雑誌掲載論文
  3. 学術雑誌

Inhibiting Aggregation of β-Amyloid by Folded and Unfolded Forms of Fimbrial Protein of Gram-Negative Bacteria

http://hdl.handle.net/2237/27357
http://hdl.handle.net/2237/27357
e45aba18-e503-43a8-b63f-8c32e2c7a93d
名前 / ファイル ライセンス アクション
manuscript_slct_201700658R2.pdf manuscript_slct_201700658R2.pdf ファイル公開日:2018/09/29 (1.6 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-02-05
タイトル
タイトル Inhibiting Aggregation of β-Amyloid by Folded and Unfolded Forms of Fimbrial Protein of Gram-Negative Bacteria
言語 en
著者 Yamamoto, Keisuke

× Yamamoto, Keisuke

WEKO 75012

en Yamamoto, Keisuke

Search repository
Oyaizu, Misa

× Oyaizu, Misa

WEKO 75013

en Oyaizu, Misa

Search repository
Takahashi, Tsuyoshi

× Takahashi, Tsuyoshi

WEKO 75014

en Takahashi, Tsuyoshi

Search repository
Watanabe, Yoshihito

× Watanabe, Yoshihito

WEKO 75015

en Watanabe, Yoshihito

Search repository
Shoji, Osami

× Shoji, Osami

WEKO 75016

en Shoji, Osami

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is the peer reviewed version of the following article: [K. Yamamoto, M. Oyaizu, T. Takahashi, Y. Watanabe, O. Shoji.(2017), Inhibiting Aggregation of β-Amyloid by Folded and Unfolded Forms of Fimbrial Protein of Gram-Negative Bacteria. ChemistrySelect,2:9058–9062. doi:10.1002/slct.201700658], which has been published in final form at [http://doi.org/10.1002/slct.201700658]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
抄録
内容記述 Inhibition self-assembly of β-amyloid (Aβ) is considered to be a strategy that can be potentially useful to develop treatment for Alzheimer's disease (AD). We have discovered that a protein unit that is found in the fimbriae of Gram-negative bacteria, which has a vacant site for a β-sheet strand, prevents Aβ oligomerization effectively. Moreover, we found that a soluble but denatured form of this protein shows even higher potency. Our results also demonstrate the applicability of denatured proteins as pharmaceutical material.
言語 en
内容記述タイプ Abstract
出版者
言語 en
出版者 Wiley
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1002/slct.201700658
ISSN
収録物識別子タイプ EISSN
収録物識別子 2365-6549
書誌情報 en : ChemistrySelect

巻 2, p. 9058-9062, 発行日 2017-09-29
著者版フラグ
値 author
URI
識別子 http://doi.org/10.1002/slct.201700658
識別子タイプ DOI
URI
識別子 http://hdl.handle.net/2237/27357
識別子タイプ HDL
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