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Direct Hydroxylation of Benzene to Phenol by Cytochrome P450BM3 Triggered by Amino Acid Derivatives
http://hdl.handle.net/2237/27358
http://hdl.handle.net/2237/27358df759356-7154-4821-95e2-f5208b44ad9a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Sota_paper_final20170522.pdf ファイル公開日:2018/08/21 (1.3 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-02-05 | |||||
| タイトル | ||||||
| タイトル | Direct Hydroxylation of Benzene to Phenol by Cytochrome P450BM3 Triggered by Amino Acid Derivatives | |||||
| 言語 | en | |||||
| 著者 |
Shoji, Osami
× Shoji, Osami× Yanagisawa, Sota× Kyle, Stanfield Joshua× Suzuki, Kazuto× Cong, Zhiqi× Sugimoto, Hiroshi× Shiro, Yoshitsugu× Watanabe, Yoshihito |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | This is the peer reviewed version of the following article: [O. Shoji, S. Yanagisawa, J. K. Stanfield, K. Suzuki, Z. Cong, H. Sugimoto, Y. Shiro, Y. Watanabe.(2017), Direct Hydroxylation of Benzene to Phenol by Cytochrome P450BM3 Triggered by Amino Acid Derivatives.Angewandte Chemie International Edition.,56: 10324–10329. doi:10.1002/anie.201703461], which has been published in final form at [http://doi.org/10.1002/anie.201703461]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The selective hydroxylation of benzene to phenol, without the formation of side products resulting from overoxidation, is catalyzed by cytochrome P450BM3 with the assistance of amino acid derivatives as decoy molecules. The catalytic turnover rate and the total turnover number reached 259 min−1 P450BM3−1 and 40 200 P450BM3−1 when N-heptyl-l-proline modified with l-phenylalanine (C7-l-Pro-l-Phe) was used as the decoy molecule. This work shows that amino acid derivatives with a totally different structure from fatty acids can be used as decoy molecules for aromatic hydroxylation by wild-type P450BM3. This method for non-native substrate hydroxylation by wild-type P450BM3 has the potential to expand the utility of P450BM3 for biotransformations. | |||||
| 言語 | en | |||||
| 出版者 | ||||||
| 出版者 | Wiley | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1002/anie.201703461 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 1433-7851 | |||||
| 書誌情報 |
en : Angewandte Chemie International Edition 巻 56, p. 10324-10329, 発行日 2017-08-21 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
| URI | ||||||
| 識別子 | http://doi.org/10.1002/anie.201703461 | |||||
| 識別子タイプ | DOI | |||||
| URI | ||||||
| 識別子 | http://hdl.handle.net/2237/27358 | |||||
| 識別子タイプ | HDL | |||||
