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  1. B300 農学部/生命農学研究科
  2. B300a 雑誌掲載論文
  3. 学術雑誌

Extracellular vesicle-mediated MFG-E8 localization in the extracellular matrix is required for its integrin-dependent function in mouse mammary epithelial cells

http://hdl.handle.net/2237/00027430
http://hdl.handle.net/2237/00027430
86b63a98-1f63-4dfe-8052-91b7ac25c42f
名前 / ファイル ライセンス アクション
Ooishi_et_al_revision_deposit_1.pdf Ooishi_et_al_revision_deposit_1 (282.0 kB)
Figs_deposit.pdf Figs_deposit (6.6 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-03-15
タイトル
タイトル Extracellular vesicle-mediated MFG-E8 localization in the extracellular matrix is required for its integrin-dependent function in mouse mammary epithelial cells
言語 en
著者 Ooishi, Takuya

× Ooishi, Takuya

WEKO 75272

en Ooishi, Takuya

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Nadano, Daita

× Nadano, Daita

WEKO 75273

en Nadano, Daita

Search repository
Matsuda, Tsukasa

× Matsuda, Tsukasa

WEKO 75274

en Matsuda, Tsukasa

Search repository
Oshima, Kenzi

× Oshima, Kenzi

WEKO 75275

en Oshima, Kenzi

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is the pre-peer reviewed version of the following article: [Ooishi, T., Nadano, D., Matsuda, T. and Oshima, K. (2017), Extracellular vesicle-mediated MFG-E8 localization in the extracellular matrix is required for its integrin-dependent function in mouse mammary epithelial cells. Genes Cells, 22: 885–899. doi:10.1111/gtc.12521], which has been published in final form at [http://doi.org/10.1111/gtc.12521]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
キーワード
主題Scheme Other
主題 MFG-E8
キーワード
主題Scheme Other
主題 extracellular matrix
キーワード
主題Scheme Other
主題 extracellular vesicle
キーワード
主題Scheme Other
主題 integrin
キーワード
主題Scheme Other
主題 mammary gland
抄録
内容記述 Milk fat globule-EGF factor 8 (MFG-E8) is a divalent-binding secretory protein possessing an Arg-Gly-Asp (RGD) motif and a phosphatidylserine (PS)-binding motif. This protein has been shown to be involved in mammary gland development and morphogenesis. Integrin-binding activity is necessary for these MFG-E8-dependent cell processes. Although the target cells and molecules of MFG-E8 in the cellular microenvironment are important to understand its physiological function, its localization is largely unclear. Here, we found that mouse MFG-E8 localized to the basal lamina of the mammary gland during involution. In a model system of mammary COMMA-1D cells, exogenously and endogenously expressed MFG-E8 was deposited in the extracellular matrix (ECM) with membranous particles dependently on the PS-binding motifs in the discoidin domains that were essential for association ability to extracellular vesicles (EVs). These data showed the basal MFG-E8 localization mechanism in which EVs served as a scaffold. Such an immobilized MFG-E8 associating with cell substrata but not soluble one in the culture media promoted integrin-dependent suppression of β-casein expression. These results suggest that MFG-E8 requires EVs to transduce cellular signals from the basolateral side of the adhesion cells by accumulating in ECM.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開日: 2018/10/01
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Wiley
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1111/gtc.12521
ISSN
収録物識別子タイプ PISSN
収録物識別子 1356-9597
書誌情報 en : Genes to Cells

巻 22, 号 10, p. 885-899, 発行日 2017-10
著者版フラグ
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