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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Origin and initiation mechanisms of neuroblastoma

http://hdl.handle.net/2237/00028435
338aaa1a-b917-4a9f-9b51-a8cb821c2b2d
名前 / ファイル ライセンス アクション
180806_merge.pdf 180806_merge (376.1 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-08-07
タイトル
タイトル Origin and initiation mechanisms of neuroblastoma
著者 Tsubota, Shoma

× Tsubota, Shoma

WEKO 78695

Tsubota, Shoma

Search repository
Kadomatsu, Kenji

× Kadomatsu, Kenji

WEKO 78696

Kadomatsu, Kenji

Search repository
権利
権利情報 “This is a post-peer-review, pre-copyedit version of an article published in [Cell and Tissue Research]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00441-018-2796-z”.
キーワード
主題Scheme Other
主題 Neuroblastoma
キーワード
主題Scheme Other
主題 Neural crest cells
キーワード
主題Scheme Other
主題 Schwann cell precursors
キーワード
主題Scheme Other
主題 Sympathoadrenal progenitors
キーワード
主題Scheme Other
主題 MYCN
抄録
内容記述 Neuroblastoma is an embryonal malignancy that affects normal development of the adrenal medulla and paravertebral sympathetic ganglia in early childhood. Extensive studies have revealed the molecular characteristics of human neuroblastomas, including abnormalities at genome, epigenome and transcriptome levels. However, neuroblastoma initiation mechanisms and even its origin are long-standing mysteries. In this review article, we summarize the current knowledge about normal development of putative neuroblastoma sources, namely sympathoadrenal lineage of neural crest cells and Schwann cell precursors that were recently identified as the source of adrenal chromaffin cells. A plausible origin of enigmatic stage 4S neuroblastoma is also discussed. With regard to the initiation mechanisms, we review genetic abnormalities in neuroblastomas and their possible association to initiation mechanisms. We also summarize evidences of neuroblastoma initiation observed in genetically engineered animal models, in which epigenetic alterations were involved, including transcriptomic upregulation by N-Myc and downregulation by polycomb repressive complex 2. Finally, several in vitro experimental methods are proposed that hopefully will accelerate our comprehension of neuroblastoma initiation. Thus, this review summarizes the state-of-the-art knowledge about the mechanisms of neuroblastoma initiation, which is critical for developing new strategies to cure children with neuroblastoma.
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2019/05/01
内容記述タイプ Other
出版者
出版者 Springer
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s00441-018-2796-z
ISSN
収録物識別子タイプ ISSN
収録物識別子 0302-766X
書誌情報 Cell and Tissue Research

巻 372, 号 2, p. 211-221, 発行日 2018-05
著者版フラグ
値 author
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