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Origin and initiation mechanisms of neuroblastoma
http://hdl.handle.net/2237/00028435
http://hdl.handle.net/2237/00028435338aaa1a-b917-4a9f-9b51-a8cb821c2b2d
名前 / ファイル | ライセンス | アクション |
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180806_merge (376.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-08-07 | |||||
タイトル | ||||||
タイトル | Origin and initiation mechanisms of neuroblastoma | |||||
言語 | en | |||||
著者 |
Tsubota, Shoma
× Tsubota, Shoma× Kadomatsu, Kenji |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | “This is a post-peer-review, pre-copyedit version of an article published in [Cell and Tissue Research]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00441-018-2796-z”. | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Neuroblastoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Neural crest cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Schwann cell precursors | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Sympathoadrenal progenitors | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | MYCN | |||||
抄録 | ||||||
内容記述 | Neuroblastoma is an embryonal malignancy that affects normal development of the adrenal medulla and paravertebral sympathetic ganglia in early childhood. Extensive studies have revealed the molecular characteristics of human neuroblastomas, including abnormalities at genome, epigenome and transcriptome levels. However, neuroblastoma initiation mechanisms and even its origin are long-standing mysteries. In this review article, we summarize the current knowledge about normal development of putative neuroblastoma sources, namely sympathoadrenal lineage of neural crest cells and Schwann cell precursors that were recently identified as the source of adrenal chromaffin cells. A plausible origin of enigmatic stage 4S neuroblastoma is also discussed. With regard to the initiation mechanisms, we review genetic abnormalities in neuroblastomas and their possible association to initiation mechanisms. We also summarize evidences of neuroblastoma initiation observed in genetically engineered animal models, in which epigenetic alterations were involved, including transcriptomic upregulation by N-Myc and downregulation by polycomb repressive complex 2. Finally, several in vitro experimental methods are proposed that hopefully will accelerate our comprehension of neuroblastoma initiation. Thus, this review summarizes the state-of-the-art knowledge about the mechanisms of neuroblastoma initiation, which is critical for developing new strategies to cure children with neuroblastoma. | |||||
言語 | en | |||||
内容記述タイプ | Abstract | |||||
内容記述 | ||||||
内容記述 | ファイル公開:2019/05/01 | |||||
言語 | ja | |||||
内容記述タイプ | Other | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Springer | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプresource | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
出版タイプ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1007/s00441-018-2796-z | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0302-766X | |||||
書誌情報 |
en : Cell and Tissue Research 巻 372, 号 2, p. 211-221, 発行日 2018-05 |
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著者版フラグ | ||||||
値 | author |