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Effect of postoperative doxorubicin administration on ischemic wound healing
https://doi.org/10.18999/nagjms.80.3.357
https://doi.org/10.18999/nagjms.80.3.3571f4aba7e-52d9-4472-8d99-a78d438c6409
名前 / ファイル | ライセンス | アクション |
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08_Morishita.pdf (67.2 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2018-08-31 | |||||
タイトル | ||||||
タイトル | Effect of postoperative doxorubicin administration on ischemic wound healing | |||||
言語 | en | |||||
著者 |
Morishita, Tsuyoshi
× Morishita, Tsuyoshi× Toriyama, Kazuhiro× Takanari, Keisuke× Yagi, Shunjiro× Ebisawa, Katsumi× Hishida, Masashi× Narita, Yuji× Osaga, Satoshi× Nishida, Yoshihiro× Kamei, Yuzuru |
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アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
権利 | ||||||
言語 | en | |||||
権利情報Resource | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
権利情報 | Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | doxorubicin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | postoperative chemotherapy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | wound tensile strength | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | normal incision wound | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ischemic skin flap | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Some patients undergo postoperative chemotherapy despite showing impaired wound healing after a major surgery. We speculated that postoperative chemotherapy further delays wound healing in these patients. This study aimed to compare the effects of doxorubicin (DXR) in ischemic skin flap and normal incisional wound models after surgery. A 2-cm incisional wound was made in group 1 rats, and saline was injected intravenously, following surgery on the same day. Incisional wound was made in group 2–5 rats, and 8 mg/kg DXR was injected intravenously, following surgery on the same day and after 7, 14, and 21 days respectively. H-shaped double flaps were made in group 6 rats, and saline was injected intravenously, following surgery on the same day. Flaps were made in group 7–10 rats, and 8 mg/kg DXR was injected intravenously, following surgery on the same day and after 7, 14, and 21 days respectively. On days 7, 14, 21, and 28 after surgery, the suture wounds were removed, tensile wound strengths were measured, and tissue samples were collected for histopathological evaluation. The tensile strength was significantly lower in the DXR-treated groups than in the control groups for both ischemic skin flaps and incision wounds. Additionally, the cross effect between DXR and ischemia was not significant. On pathological examination, DXR showed atrophic skin changes and degeneration of skin appendages on days 14–21 after the surgery in both the models. DXR decreased the wound tensile strength and caused an atrophic change in the ischemic wound. | |||||
言語 | en | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | This work was supported by JSPS Grants-in-Aid for Scientific Research (Grant Number 24592710). | |||||
言語 | en | |||||
出版者 | ||||||
出版者 | Nagoya University Graduate School of Medicine, School of Medicine | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
ID登録 | ||||||
ID登録 | 10.18999/nagjms.80.3.357 | |||||
ID登録タイプ | JaLC | |||||
関連情報 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | URI | |||||
関連識別子 | http://www.med.nagoya-u.ac.jp/medlib/nagoya_j_med_sci/803.html | |||||
ISSN(print) | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0027-7622 | |||||
ISSN(Online) | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 2186-3326 | |||||
書誌情報 |
en : Nagoya Journal of Medical Science 巻 80, 号 3, p. 357-366, 発行日 2018-08 |
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著者版フラグ | ||||||
値 | publisher |