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The mRNA-binding protein Serbp1 as an auxiliary protein associated with mammalian cytoplasmic ribosomes
http://hdl.handle.net/2237/00028538
http://hdl.handle.net/2237/000285387e500b3c-d613-400a-923d-b482e657d900
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Serbp1-201808-op (1.3 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2018-09-05 | |||||
| タイトル | ||||||
| タイトル | The mRNA-binding protein Serbp1 as an auxiliary protein associated with mammalian cytoplasmic ribosomes | |||||
| 言語 | en | |||||
| 著者 |
Muto, Akiko
× Muto, Akiko× Sugihara, Yoshihiko× Shibakawa, Minami× Oshima, Kenzi× Matsuda, Tsukasa× Nadano, Daita |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | This is the peer reviewed version of the following article: [Muto A, Sugihara Y, Shibakawa M, Oshima K, Matsuda T, Nadano D. The mRNA‐binding protein Serbp1 as an auxiliary protein associated with mammalian cytoplasmic ribosomes. Cell Biochem Funct. 2018;36:312–322. https://doi.org/10.1002/cbf.3350], which has been published in final form at [https://doi.org/10.1002/cbf.3350]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cytoplasmic ribosome | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | gene expression | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | isoform | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | malignant tumour | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | mammal | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | mRNA‐binding protein | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | polysome | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | translational control | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | While transcription plays an obviously important role in gene expression, translation has recently been emerged as a key step that defines the composition and quality of the proteome in the cell of higher eukaryotes including mammals. Selective translation is supposed to be regulated by the structural heterogeneity of cytoplasmic ribosomes including differences in protein composition and chemical modifications. However, the current knowledge on the heterogeneity of mammalian ribosomes is limited. Here, we report mammalian Serbp1 as a ribosome‐associated protein. The translated products of Serbp1 gene, including the longest isoform, were found to be localized in the nucleolus as well as in the cytoplasm. Subcellular fractionation indicated that most of cytoplasmic Serbp1 molecules were precipitated by ultracentrifugation. Proteomic analysis identified Serbp1 in the cytoplasmic ribosomes of the rodent testis. Polysome profiling suggested that Serbp1, as a component of the small 40S subunit, was included in translating ribosomes (polysomes). Cosedimentation of Serbp1 with the 40S subunit was observed after dissociation of the ribosomal subunits. Serbp1 was also included in the ribosomes of human cancer cells, which may lead to a mechanistic understanding of an emerging link between Serbp1 and tumour progression. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ファイル公開：2019/08/01 | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | Wiley | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1002/cbf.3350 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0263-6484 | |||||
| 書誌情報 |
en : Cell Biochemistry and Function 巻 36, 号 6, p. 312-322, 発行日 2018-08 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
