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  1. B300 農学部/生命農学研究科
  2. B300a 雑誌掲載論文
  3. 学術雑誌

The mRNA-binding protein Serbp1 as an auxiliary protein associated with mammalian cytoplasmic ribosomes

http://hdl.handle.net/2237/00028538
http://hdl.handle.net/2237/00028538
7e500b3c-d613-400a-923d-b482e657d900
名前 / ファイル ライセンス アクション
Serbp1-201808-op.pdf Serbp1-201808-op (1.3 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-09-05
タイトル
タイトル The mRNA-binding protein Serbp1 as an auxiliary protein associated with mammalian cytoplasmic ribosomes
言語 en
著者 Muto, Akiko

× Muto, Akiko

WEKO 85106

en Muto, Akiko

Search repository
Sugihara, Yoshihiko

× Sugihara, Yoshihiko

WEKO 85107

en Sugihara, Yoshihiko

Search repository
Shibakawa, Minami

× Shibakawa, Minami

WEKO 85108

en Shibakawa, Minami

Search repository
Oshima, Kenzi

× Oshima, Kenzi

WEKO 85109

en Oshima, Kenzi

Search repository
Matsuda, Tsukasa

× Matsuda, Tsukasa

WEKO 85110

en Matsuda, Tsukasa

Search repository
Nadano, Daita

× Nadano, Daita

WEKO 85111

en Nadano, Daita

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 This is the peer reviewed version of the following article: [Muto A, Sugihara Y, Shibakawa M, Oshima K, Matsuda T, Nadano D. The mRNA‐binding protein Serbp1 as an auxiliary protein associated with mammalian cytoplasmic ribosomes. Cell Biochem Funct. 2018;36:312–322. https://doi.org/10.1002/cbf.3350], which has been published in final form at [https://doi.org/10.1002/cbf.3350]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
キーワード
主題Scheme Other
主題 cytoplasmic ribosome
キーワード
主題Scheme Other
主題 gene expression
キーワード
主題Scheme Other
主題 isoform
キーワード
主題Scheme Other
主題 malignant tumour
キーワード
主題Scheme Other
主題 mammal
キーワード
主題Scheme Other
主題 mRNA‐binding protein
キーワード
主題Scheme Other
主題 polysome
キーワード
主題Scheme Other
主題 translational control
抄録
内容記述 While transcription plays an obviously important role in gene expression, translation has recently been emerged as a key step that defines the composition and quality of the proteome in the cell of higher eukaryotes including mammals. Selective translation is supposed to be regulated by the structural heterogeneity of cytoplasmic ribosomes including differences in protein composition and chemical modifications. However, the current knowledge on the heterogeneity of mammalian ribosomes is limited. Here, we report mammalian Serbp1 as a ribosome‐associated protein. The translated products of Serbp1 gene, including the longest isoform, were found to be localized in the nucleolus as well as in the cytoplasm. Subcellular fractionation indicated that most of cytoplasmic Serbp1 molecules were precipitated by ultracentrifugation. Proteomic analysis identified Serbp1 in the cytoplasmic ribosomes of the rodent testis. Polysome profiling suggested that Serbp1, as a component of the small 40S subunit, was included in translating ribosomes (polysomes). Cosedimentation of Serbp1 with the 40S subunit was observed after dissociation of the ribosomal subunits. Serbp1 was also included in the ribosomes of human cancer cells, which may lead to a mechanistic understanding of an emerging link between Serbp1 and tumour progression.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2019/08/01
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Wiley
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1002/cbf.3350
ISSN
収録物識別子タイプ PISSN
収録物識別子 0263-6484
書誌情報 en : Cell Biochemistry and Function

巻 36, 号 6, p. 312-322, 発行日 2018-08
著者版フラグ
値 author
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