{"_buckets": {"deposit": "60aabe3f-c579-4ef8-8793-1d0a0e5a7eeb"}, "_deposit": {"id": "26361", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "26361"}, "status": "published"}, "_oai": {"id": "oai:nagoya.repo.nii.ac.jp:00026361", "sets": ["501"]}, "author_link": ["85258", "85259", "85260", "85261", "85262", "85263"], "item_10_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2018-08", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "361", "bibliographicPageStart": "357", "bibliographicVolumeNumber": "67", "bibliographic_titles": [{"bibliographic_title": "Parasitology International", "bibliographic_titleLang": "en"}]}]}, "item_10_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Hymenolepis diminuta is a parasitic tapeworm of the rat small intestine and is recognized as a useful model for the analysis of cestode-host interactions. In this study, we analyzed factors affecting the biomass of the tapeworm through use of rat strains carrying genetic mutations, namely X-linked severe combined immunodeficiency (xscid; T, B and NK cells deficiency), nude (rnu; T cell deficiency), and mast cell deficient rats. The worm biomass of F344-xscid rats after infection with 5 cysticercoids was much larger than control F344 rats from 3 to 8 weeks. The biomass of F344-rnu rats was also larger than the controls, but was intermediate between F344-xscid and control rats. These observations demonstrated that host immunity can control the maximal tapeworm biomass, i.e., carrying capacity, of the rat small intestine. Both T cell and other immune cells (B and NK cells) have roles in determining the carrying capacity of tapeworms. Total worm biomass and worm numbers in mast cell deficient rats (WsRC-Ws/Ws) were not significantly different from control WsRC-+/+ rats after 3 and 6 weeks of primary infection. Mast cell deficient rats displayed reinfection resistance for worm biomass but not worm expulsion. These findings suggest that the mast cell has a role for controlling the biomass of this tapeworm in reinfection alone, but does not affect the rate of worm expulsion. Overall, our findings indicate that the mast cell is not a major effector cell for the control of the carrying capacity of tapeworms. The identity of the major effector cell remains unknown.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_10_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "ファイル公開：2019-08-01", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_10_publisher_32": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier", "subitem_publisher_language": "en"}]}, "item_10_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1016/j.parint.2018.02.003", "subitem_relation_type_select": "DOI"}}]}, "item_10_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/", "subitem_rights_language": "en"}]}, "item_10_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_10_source_id_61": {"attribute_name": "ISSN（print）", "attribute_value_mlt": [{"subitem_source_identifier": "1383-5769", "subitem_source_identifier_type": "PISSN"}]}, "item_1615787544753": {"attribute_name": "出版タイプ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ohno, Tamio", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "85258", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kai, Takuya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "85259", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Miyasaka, Yuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "85260", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Maruyama, Haruhiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "85261", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishih, Akira", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "85262", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kino, Hideto", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "85263", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Ohno_T_H_diminuta-Revised.pdf", "filesize": [{"value": "267.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 267200.0, "url": {"label": "Ohno_T_H_diminuta-Revised", "objectType": "fulltext", "url": "https://nagoya.repo.nii.ac.jp/record/26361/files/Ohno_T_H_diminuta-Revised.pdf"}, "version_id": "13ba5c24-44cd-41a3-b4db-bfa193ee3e22"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Carrying capacity", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Hymenolepis diminuta", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Immune-deficient rat", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Mast cell deficient rat", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Worm biomass", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Intestinal immunity suppresses carrying capacity of rats for the model tapeworm, Hymenolepis diminuta", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Intestinal immunity suppresses carrying capacity of rats for the model tapeworm, Hymenolepis diminuta", "subitem_title_language": "en"}]}, "item_type_id": "10", "owner": "1", "path": ["501"], "permalink_uri": "http://hdl.handle.net/2237/00028564", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2018-09-11"}, "publish_date": "2018-09-11", "publish_status": "0", "recid": "26361", "relation": {}, "relation_version_is_last": true, "title": ["Intestinal immunity suppresses carrying capacity of rats for the model tapeworm, Hymenolepis diminuta"], "weko_shared_id": -1}