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Intestinal immunity suppresses carrying capacity of rats for the model tapeworm, Hymenolepis diminuta
http://hdl.handle.net/2237/00028564
http://hdl.handle.net/2237/00028564e18e4bce-8da4-42ef-9fc8-17d696f7ed4b
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Ohno_T_H_diminuta-Revised (267.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-09-11 | |||||
| タイトル | ||||||
| タイトル | Intestinal immunity suppresses carrying capacity of rats for the model tapeworm, Hymenolepis diminuta | |||||
| 言語 | en | |||||
| 著者 |
Ohno, Tamio
× Ohno, Tamio× Kai, Takuya× Miyasaka, Yuki× Maruyama, Haruhiko× Ishih, Akira× Kino, Hideto |
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| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Carrying capacity | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Hymenolepis diminuta | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Immune-deficient rat | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Mast cell deficient rat | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Worm biomass | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Hymenolepis diminuta is a parasitic tapeworm of the rat small intestine and is recognized as a useful model for the analysis of cestode-host interactions. In this study, we analyzed factors affecting the biomass of the tapeworm through use of rat strains carrying genetic mutations, namely X-linked severe combined immunodeficiency (xscid; T, B and NK cells deficiency), nude (rnu; T cell deficiency), and mast cell deficient rats. The worm biomass of F344-xscid rats after infection with 5 cysticercoids was much larger than control F344 rats from 3 to 8 weeks. The biomass of F344-rnu rats was also larger than the controls, but was intermediate between F344-xscid and control rats. These observations demonstrated that host immunity can control the maximal tapeworm biomass, i.e., carrying capacity, of the rat small intestine. Both T cell and other immune cells (B and NK cells) have roles in determining the carrying capacity of tapeworms. Total worm biomass and worm numbers in mast cell deficient rats (WsRC-Ws/Ws) were not significantly different from control WsRC-+/+ rats after 3 and 6 weeks of primary infection. Mast cell deficient rats displayed reinfection resistance for worm biomass but not worm expulsion. These findings suggest that the mast cell has a role for controlling the biomass of this tapeworm in reinfection alone, but does not affect the rate of worm expulsion. Overall, our findings indicate that the mast cell is not a major effector cell for the control of the carrying capacity of tapeworms. The identity of the major effector cell remains unknown. | |||||
| 言語 | en | |||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | ファイル公開：2019-08-01 | |||||
| 言語 | ja | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.parint.2018.02.003 | |||||
| ISSN（print） | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 1383-5769 | |||||
| 書誌情報 |
en : Parasitology International 巻 67, 号 4, p. 357-361, 発行日 2018-08 |
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| 著者版フラグ | ||||||
| 値 | author | |||||
