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  1. C100 医学部/医学系研究科
  2. C100a 雑誌掲載論文
  3. 学術雑誌

Intestinal immunity suppresses carrying capacity of rats for the model tapeworm, Hymenolepis diminuta

http://hdl.handle.net/2237/00028564
http://hdl.handle.net/2237/00028564
e18e4bce-8da4-42ef-9fc8-17d696f7ed4b
名前 / ファイル ライセンス アクション
Ohno_T_H_diminuta-Revised.pdf Ohno_T_H_diminuta-Revised (267.2 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2018-09-11
タイトル
タイトル Intestinal immunity suppresses carrying capacity of rats for the model tapeworm, Hymenolepis diminuta
言語 en
著者 Ohno, Tamio

× Ohno, Tamio

WEKO 85258

en Ohno, Tamio

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Kai, Takuya

× Kai, Takuya

WEKO 85259

en Kai, Takuya

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Miyasaka, Yuki

× Miyasaka, Yuki

WEKO 85260

en Miyasaka, Yuki

Search repository
Maruyama, Haruhiko

× Maruyama, Haruhiko

WEKO 85261

en Maruyama, Haruhiko

Search repository
Ishih, Akira

× Ishih, Akira

WEKO 85262

en Ishih, Akira

Search repository
Kino, Hideto

× Kino, Hideto

WEKO 85263

en Kino, Hideto

Search repository
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利
言語 en
権利情報 © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
キーワード
主題Scheme Other
主題 Carrying capacity
キーワード
主題Scheme Other
主題 Hymenolepis diminuta
キーワード
主題Scheme Other
主題 Immune-deficient rat
キーワード
主題Scheme Other
主題 Mast cell deficient rat
キーワード
主題Scheme Other
主題 Worm biomass
抄録
内容記述 Hymenolepis diminuta is a parasitic tapeworm of the rat small intestine and is recognized as a useful model for the analysis of cestode-host interactions. In this study, we analyzed factors affecting the biomass of the tapeworm through use of rat strains carrying genetic mutations, namely X-linked severe combined immunodeficiency (xscid; T, B and NK cells deficiency), nude (rnu; T cell deficiency), and mast cell deficient rats. The worm biomass of F344-xscid rats after infection with 5 cysticercoids was much larger than control F344 rats from 3 to 8 weeks. The biomass of F344-rnu rats was also larger than the controls, but was intermediate between F344-xscid and control rats. These observations demonstrated that host immunity can control the maximal tapeworm biomass, i.e., carrying capacity, of the rat small intestine. Both T cell and other immune cells (B and NK cells) have roles in determining the carrying capacity of tapeworms. Total worm biomass and worm numbers in mast cell deficient rats (WsRC-Ws/Ws) were not significantly different from control WsRC-+/+ rats after 3 and 6 weeks of primary infection. Mast cell deficient rats displayed reinfection resistance for worm biomass but not worm expulsion. These findings suggest that the mast cell has a role for controlling the biomass of this tapeworm in reinfection alone, but does not affect the rate of worm expulsion. Overall, our findings indicate that the mast cell is not a major effector cell for the control of the carrying capacity of tapeworms. The identity of the major effector cell remains unknown.
言語 en
内容記述タイプ Abstract
内容記述
内容記述 ファイル公開:2019-08-01
言語 ja
内容記述タイプ Other
出版者
言語 en
出版者 Elsevier
言語
言語 eng
資源タイプ
資源タイプresource http://purl.org/coar/resource_type/c_6501
タイプ journal article
出版タイプ
出版タイプ AM
出版タイプResource http://purl.org/coar/version/c_ab4af688f83e57aa
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 https://doi.org/10.1016/j.parint.2018.02.003
ISSN(print)
収録物識別子タイプ PISSN
収録物識別子 1383-5769
書誌情報 en : Parasitology International

巻 67, 号 4, p. 357-361, 発行日 2018-08
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